Abcc9
Gene Detail

Symbol Name ID

Abcc9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 MGI:1352630

Synonyms

Sur2, SUR2A, SUR2B

Feature Type

protein coding gene

Genetic Map

Chromosome 6

74.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr6:142587862-142702274 bp, - strand From NCBI annotation of GRCm38   114413 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56521  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Abcc9

Human homologs

Human Homolog		ABCC9, ATP-binding cassette, sub-family C (CFTR/MRP), member 9
NCBI Gene ID		10060
neXtProt AC		NX_O60706
Human Synonyms		ABC37, ATFB12, CANTU, CMD1O, SUR2
Human Chr (Location)		12p12.1; chr12:21950323-22089628 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human ABCC9

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for disruptions in this gene display lower serum glucose, enhanced insulin action, growth retardation, hypertension and spontaneous death starting at 6 weeks of age due to episodic coronary artery vasospasm.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	defense response to virus, potassium ion import, ...
Component	ATP-sensitive potassium channel complex, integral to membrane, ...
Function	ATPase activity, ATPase activity, coupled to transmembrane movement of substances, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (97)    Tissues (96)    Images (11)
Theiler Stages: 22, 25, 28

Assay Type	Results
RNA in situ	94
RT-PCR	3

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000030249 (Evidence)
Entrez Gene	20928 (Evidence)
DFCI	TC1586145, TC1592047, TC1594455, TC1595904, TC1597223
DoTS	DT.101241620, DT.529843, DT.87031804, DT.91337465, DT.97409096, DT.97410840
NIA Mouse Gene Index	U028007
Consensus CDS Project	CCDS39696.1, CCDS39697.1, CCDS39698.1, CCDS39699.1
International Mouse Knockout Project Status	Abcc9

Sequences

Length	Strain/Species
genomic	20928	NCBI Gene Model | MGI Sequence Detail	114413	C57BL/6J
transcript	NM_021041	RefSeq | MGI Sequence Detail	7538	C57BL/6
polypeptide	P70170	UniProt | EBI | MGI Sequence Detail	1546	Not Applicable

All sequences(51) RefSeq(9) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(971 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR017871	ABC transporter, conserved site
InterPro	IPR017940	ABC transporter, integral membrane type 1
InterPro	IPR003439	ABC transporter-like
InterPro	IPR001140	ABC transporter, transmembrane domain
InterPro	IPR011527	ABC transporter, transmembrane domain, type 1
InterPro	IPR000388	Sulphonylurea receptor
InterPro	IPR001475	Sulphonylurea receptor, type 2
Protein Ontology	PR:000003564	ATP-binding cassette sub-family C member 9

Graphical View of Protein Domain Structure

References

(Earliest) J:9177 Williams T, et al., The mouse surfeit locus contains a very tight cluster of four housekeeping genes that is conserved through evolution. Proc Natl Acad Sci U S A. 1988 May;85(10):3527-30
(Latest) J:177083 Adebiyi A, et al., Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1360-8
All references(54)

Other accession IDs

MGD-MRK-36495, MGI:107915, MGI:1889815, MGI:1889833