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Abcc9
Gene Detail
 Symbol
Name
ID
Abcc9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
MGI:1352630
Synonyms Sur2, SUR2A, SUR2B
Feature Type protein coding gene
Genetic Map
Chromosome 6
74.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:142587862-142702274 bp, - strand
From NCBI annotation of GRCm38

  114413 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56521  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Abcc9

Human
homologs
Human Homolog ABCC9, ATP-binding cassette, sub-family C (CFTR/MRP), member 9
NCBI Gene ID 10060
neXtProt AC  NX_O60706
Human Synonyms  ABC37, ATFB12, CANTU, CMD1O, SUR2
Human Chr (Location)  12p12.1; chr12:21797389-21941863 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human ABCC9
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display lower serum glucose, enhanced insulin action, growth retardation, hypertension and spontaneous death starting at 6 weeks of age due to episodic coronary artery vasospasm.
 
Interactions
Abcc9 interacts with 360 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process defense response to virus, potassium ion import, ...
Component ATP-sensitive potassium channel complex, integral component of membrane, ...
Function ATPase activity, ATPase activity, coupled to transmembrane movement of substances, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (97)    Tissues (96)    Images (11)
Theiler Stages: 22, 25, 28
Assay TypeResults
RNA in situ 94
RT-PCR 3
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030249 (Evidence)
Entrez Gene20928 (Evidence)
DFCITC1586145, TC1592047, TC1594455, TC1595904, TC1597223
DoTSDT.101241620, DT.529843, DT.87031804, DT.91337465, DT.97409096, DT.97410840
NIA Mouse Gene IndexU028007
Consensus CDS ProjectCCDS39696.1, CCDS39697.1, CCDS39698.1, CCDS39699.1
International Mouse Knockout Project StatusAbcc9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20928 NCBI Gene Model | MGI Sequence Detail 114413 C57BL/6J ±  kb
transcript NM_021041 RefSeq | MGI Sequence Detail 7538 C57BL/6 
polypeptide P70170 UniProt | EBI | MGI Sequence Detail 1546 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(21) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(1757 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR001140 ABC transporter, transmembrane domain
InterPro IPR011527 ABC transporter, transmembrane domain, type 1
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000388 Sulphonylurea receptor
InterPro IPR001475 Sulphonylurea receptor, type 2
Protein Ontology PR:000003564 ATP-binding cassette sub-family C member 9
Graphical View of Protein Domain Structure
References (Earliest) J:9177 Williams T, et al., The mouse surfeit locus contains a very tight cluster of four housekeeping genes that is conserved through evolution. Proc Natl Acad Sci U S A. 1988 May;85(10):3527-30
(Latest) J:177083 Adebiyi A, et al., Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1360-8
All references(54)
Other
accession IDs
MGD-MRK-36495, MGI:107915, MGI:1889815, MGI:1889833

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory