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Abcc9
Gene Detail
Symbol

Name
ID
Abcc9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
MGI:1352630
Synonyms
Sur2, SUR2A, SUR2B
Feature Type
protein coding gene
Genetic Map
Chromosome 6
74.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:142587862-142702274 bp, - strand
From Ensembl annotation of GRCm38

  114413 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56521  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ABCC9
Gene Tree: Abcc9

Human
homologs
ABCC9, ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10060
neXtProt AC: NX_O60706

Human Synonyms: ABC37, ATFB12, CANTU, CMD1O, SUR2

Human Chr (Location): 12p12.1; chr12:21797389-21941863 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human ABCC9

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display lower serum glucose, enhanced insulin action, growth retardation, hypertension and spontaneous death starting at 6 weeks of age due to episodic coronary artery vasospasm.
 
Interactions
Abcc9 interacts with 359 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (97)    Tissues (97)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 3
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000030249 (Evidence)
Entrez Gene 20928 (Evidence)
DFCI TC1586145, TC1592047, TC1594455, TC1595904, TC1597223
DoTS DT.101241620, DT.529843, DT.87031804, DT.91337465, DT.97409096, DT.97410840
NIA Mouse Gene Index U028007
Consensus CDS Project CCDS39696.1, CCDS39697.1, CCDS39698.1, CCDS39699.1
International Mouse Phenotyping Consortium Status Abcc9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030249 Ensembl Gene Model | MGI Sequence Detail 114413 C57BL/6J ±  kb
transcript ENSMUST00000100827 Ensembl | MGI Sequence Detail 7362 Not Applicable 
polypeptide ENSMUSP00000098390 Ensembl | MGI Sequence Detail 1546 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(23) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(1757 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR011527 ABC transporter type 1, transmembrane domain
InterPro IPR001475 ATP-binding cassette subfamily C member 9
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000388 Sulphonylurea receptor
Protein Ontology PR:000003564 ATP-binding cassette sub-family C member 9
References
(Earliest) J:9177 Williams T, et al., The mouse surfeit locus contains a very tight cluster of four housekeeping genes that is conserved through evolution. Proc Natl Acad Sci U S A. 1988 May;85(10):3527-30
(Latest) J:220734 Zhang L, et al., Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4003-8
All references(55)
Other
accession IDs
MGD-MRK-36495, MGI:107915, MGI:1889815, MGI:1889833

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory