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Abcc9 Gene Detail
Summary
  • Symbol
    Abcc9
  • Name
    ATP-binding cassette, sub-family C (CFTR/MRP), member 9
  • Synonyms
    Sur2, SUR2A, SUR2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352630
    NCBI Gene: 20928
  • Gene Overview
    MyGene.info: ABCC9
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:142587862-142702315 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      114454 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 74.35 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ABCC9, ATP binding cassette subfamily C member 9
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ABCC9, ATP binding cassette subfamily C member 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABC37, ATFB12, CANTU, CMD1O, SUR2
  • Links
    NCBI Gene ID: 10060
    neXtProt AC: NX_O60706
    UniProt: O60706

  • Chr Location
    12p12.1; chr12:21797389-21941869 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56521
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ABCC9
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Abcc9 mouse models; 3 with human ABCC9 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 3 alleles in 4 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display lower serum glucose, enhanced insulin action, growth retardation, hypertension and spontaneous death due to episodic coronary artery vasospasm. Homozygous exon 5 deletion leads to cardiac mitochondrial defects, cardiomyopathy, and early postnatal death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000057137 VEGA Gene Model | MGI Sequence Detail 114454 C57BL/6J ±  kb
    transcript OTTMUST00000140695 VEGA | MGI Sequence Detail 7306 Not Applicable  
    polypeptide OTTMUSP00000073641 VEGA | MGI Sequence Detail 1546 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1759 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 10
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36495, MGI:107915, MGI:1889815, MGI:1889833
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:9177 Williams T, et al., The mouse surfeit locus contains a very tight cluster of four housekeeping genes that is conserved through evolution. Proc Natl Acad Sci U S A. 1988 May;85(10):3527-30
    • Latest
      J:256956 Brinegar AE, et al., Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions. Elife. 2017 Aug 11;6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory