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Stau2 Gene Detail
Summary
  • Symbol
    Stau2
  • Name
    staufen double-stranded RNA binding protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352508
    NCBI Gene: 29819
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:16298898-16590336 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 5.05 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7592 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352508
 protein coding gene Chr1:16298898-16591228 (-)
129S1/SvImJ ENSMUSG00200018462
 protein coding gene Chr1:13893177-13967515 (-)
129S1/SvImJ ENSMUSGG00200054479
 protein coding gene Chr1:13846876-13893193 (-)
A/J ENSMUSG00195026768
 protein coding gene Chr1:13693271-13762261 (-)
A/J ENSMUSGG00195054968
 protein coding gene Chr1:13646966-13693287 (-)
AKR/J ENSMUSG00220008191
 protein coding gene Chr1:13744989-13819018 (-)
AKR/J ENSMUSGG00220054568
 protein coding gene Chr1:13692262-13745005 (-)
BALB/cJ ENSMUSG00180024788
 protein coding gene Chr1:13759599-13828589 (-)
BALB/cJ ENSMUSGG00180055036
 protein coding gene Chr1:13713296-13759615 (-)
C3H/HeJ ENSMUSG00175000211
 protein coding gene Chr1:13685682-13754663 (-)
C3H/HeJ ENSMUSGG00175054558
 protein coding gene Chr1:13639379-13685698 (-)
C57BL/6NJ ENSMUSGG00215055583
 protein coding gene Chr1:13677801-13724122 (-)
C57BL/6NJ ENSMUSG00215010729
 protein coding gene Chr1:13724106-13793074 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013967
 protein coding gene Chr1:12168514-12461003 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210002633
 protein coding gene Chr1:13551418-13620392 (-)
CBA/J ENSMUSGG00210054756
 protein coding gene Chr1:13505113-13551434 (-)
DBA/2J ENSMUSGG00185057744
 protein coding gene Chr1:14569471-14615788 (-)
DBA/2J ENSMUSG00185003806
 protein coding gene Chr1:14615772-14684720 (-)
FVB/NJ ENSMUSG00205015171
 protein coding gene Chr1:13792279-13856425 (-)
FVB/NJ ENSMUSGG00205054249
 protein coding gene Chr1:13745977-13792295 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230017150
 protein coding gene Chr1:14594517-14668856 (-)
LP/J ENSMUSGG00230055735
 protein coding gene Chr1:14548219-14594533 (-)
NOD/ShiLtJ ENSMUSG00190026314
 protein coding gene Chr1:13660981-13729962 (-)
NOD/ShiLtJ ENSMUSGG00190054848
 protein coding gene Chr1:13614677-13660997 (-)
NZO/HlLtJ ENSMUSGG00225055530
 protein coding gene Chr1:17945255-17997995 (-)
NZO/HlLtJ ENSMUSG00225004613
 protein coding gene Chr1:17997979-18073262 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010025799
 protein coding gene Chr1:14069604-14380549 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    STAU2, staufen double-stranded RNA binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STAU2, staufen double-stranded RNA binding protein 2
  • Synonyms
    39K2, 39K3
  • Links
    NCBI Gene ID: 27067
    UniProt: Q9NUL3

  • Chr Location
    8q21.11; chr8:73420369-73747708 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a hypomorphic gene trap allele show impaired motor coordination but increased motor learning capacity in the rotarod test.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    65
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    865
  • Tissues
    92
  • cDNA Data
    59
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025920 Ensembl Gene Model | MGI Sequence Detail 291439 C57BL/6J ±  kb
    transcript ENSMUST00000162751 Ensembl | MGI Sequence Detail 3030 Not Applicable  
    polypeptide ENSMUSP00000124505 Ensembl | MGI Sequence Detail 570 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000015727 double-stranded RNA-binding protein Staufen homolog 2
      (term hierarchy)
    • PDB
      1UHZ
    • InterPro Domains
      IPR014720 Double-stranded RNA-binding domain
      IPR051740 Double-stranded RNA-binding domain-containing protein
      IPR044474 Staufen 2, fourth double-stranded RNA binding domain
      IPR044464 Staufen 2, second double-stranded RNA binding domain
      IPR044473 Staufen 2, third double-stranded RNA binding domain
      IPR032478 Staufen, C-terminal
    • GlyGen
      Q8CJ67 6 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 61
      Primer pair 5
      Antibodies 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 13
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:58925 Buchner G, et al., Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region. Genomics. 1999 Nov 15;62(1):113-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory