Ndrg3 MGI Mouse Gene Detail - MGI:1352499 - N-myc downstream regulated gene 3

Ndrg3 Gene Detail

Symbol

Ndrg3
Name

N-myc downstream regulated gene 3
Synonyms

4833415O14Rik, Ndr3

Feature Type

protein coding gene
IDs

MGI:1352499
NCBI Gene: 29812
Alliance

gene page

Sequence Map

Chr2:156927345-156992056 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

64712 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 77.89 cM
Mapping Data

3 experiments

Human Ortholog

NDRG3, NDRG family member 3

Vertebrate Orthologs

8

Human Ortholog

NDRG3, NDRG family member 3
Orthology source: HGNC, HomoloGene
Links

HGNC:14462

NCBI Gene ID: 57446

neXtProt AC: NX_Q9UGV2

UniProt: Q9UGV2
Chr Location

20q11.23; chr20:36651766-36746138 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 40903
1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 frog, western clawed
HCOP

human homology predictions: NDRG3
Gene Tree

Ndrg3

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

60
Endonuclease-mediated

1
Gene trapped

57
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

Homozygous mutation of this gene results in lethality before weaning.

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All GO Annotations

4
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

127
Tissues

78
cDNA Data

14
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ndrg4

ZFIN ndrg3a, ndrg3b

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Ndrg3 interacts with 321 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

77
RefSeq

18
UniProt

4
CCDS

CCDS16971.1, CCDS50780.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000016170	VEGA Gene Model \| MGI Sequence Detail	64712	C57BL/6J	± kb
transcript	OTTMUST00000038690	VEGA \| MGI Sequence Detail	2612	Not Applicable
polypeptide	OTTMUSP00000017304	VEGA \| MGI Sequence Detail	388	Not Applicable

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SNPs within 2kb

696 from dbSNP Build 142

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UniProt

4 Sequences
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR004142 NDRG

IPR030692 Protein NDRG3

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All nucleic 15

cDNA 15

Microarray probesets 6

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MGI:2139046, MGI:2442824

Summaries

All 40

Developmental Gene Expression 4

Gene Ontology 3

Phenotypes 10
Earliest

J:58924 Okuda T, et al., Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc. Biochem Biophys Res Commun. 1999 Dec 9;266(1):208-15
Latest

J:263996 Cao H, et al., A new plasmid-based microRNA inhibitor system that inhibits microRNA families in transgenic mice and cells: a potential new therapeutic reagent. Gene Ther. 2016 Jun;23(6):527-42

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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