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Ndrg3 Gene Detail
Summary
  • Symbol
    Ndrg3
  • Name
    N-myc downstream regulated gene 3
  • Synonyms
    4833415O14Rik, Ndr3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352499
    NCBI Gene: 29812
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:156927345-156992056 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 77.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    696 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352499
protein coding gene Chr2:156927342-156992111 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026772
protein coding gene Chr2:161878479-161959883 (-)
A/J MGP_AJ_G0026738
protein coding gene Chr2:155422147-155489951 (-)
AKR/J MGP_AKRJ_G0026709
protein coding gene Chr2:159967623-160055841 (-)
BALB/cJ MGP_BALBcJ_G0026747
protein coding gene Chr2:155705889-155773484 (-)
C3H/HeJ MGP_C3HHeJ_G0026489
protein coding gene Chr2:160292392-160363711 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027196
protein coding gene Chr2:166572933-166728454 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024566
protein coding gene Chr2:148876925-148941670 (-)
CAST/EiJ MGP_CASTEiJ_G0025951
protein coding gene Chr2:160634041-160804732 (-)
CBA/J MGP_CBAJ_G0026466
protein coding gene Chr2:172688535-172776712 (-)
DBA/2J MGP_DBA2J_G0026604
protein coding gene Chr2:154592818-154659299 (-)
FVB/NJ MGP_FVBNJ_G0026571
protein coding gene Chr2:152976145-153051814 (-)
LP/J MGP_LPJ_G0026709
protein coding gene Chr2:161959127-162056142 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026592
protein coding gene Chr2:176552284-176628410 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027252
protein coding gene Chr2:159801822-159878909 (-)
PWK/PhJ MGP_PWKPhJ_G0025685
protein coding gene Chr2:154100309-154169496 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025488
protein coding gene Chr2:158740413-158819682 (-)
WSB/EiJ MGP_WSBEiJ_G0026021
protein coding gene Chr2:160688473-160760222 (-)



Homology
more
  • Human Ortholog
    NDRG3, NDRG family member 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NDRG3, NDRG family member 3
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 57446
    neXtProt AC: NX_Q9UGV2
    UniProt: Q9UGV2

  • Chr Location
    20q11.23; chr20:36651766-36746138 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality before weaning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027634 Ensembl Gene Model | MGI Sequence Detail 64712 C57BL/6J ±  kb
transcript ENSMUST00000069600 Ensembl | MGI Sequence Detail 2612 Not Applicable  
polypeptide ENSMUSP00000070052 Ensembl | MGI Sequence Detail 388 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 6
Other
Accession IDs
less
MGI:2139046, MGI:2442824
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:58924 Okuda T, et al., Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc. Biochem Biophys Res Commun. 1999 Dec 9;266(1):208-15
  • Latest
    J:263996 Cao H, et al., A new plasmid-based microRNA inhibitor system that inhibits microRNA families in transgenic mice and cells: a potential new therapeutic reagent. Gene Ther. 2016 Jun;23(6):527-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory