Zfp385a
Gene Detail

Symbol Name ID

Zfp385a zinc finger protein 385A MGI:1352495

Synonyms

Hzf, Zfp385

Feature Type

protein coding gene

Genetic Map

Chromosome 15

58.88 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr15:103313895-103340086 bp, - strand From NCBI annotation of GRCm38   26192 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8479  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Zfp385a

Human homologs

Human Homolog		ZNF385A, zinc finger protein 385A
NCBI Gene ID		25946
neXtProt AC		NX_Q96PM9
Human Synonyms		HZF, RZF, ZFP385, ZNF385
Human Chr (Location)		12q13.13; chr12:54762920-54785083 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(19) : Targeted(3) Gene trapped(16)
 

Homozygous null mice display partial postnatal lethality with gastrointestinal and intracranial hemorrhages, abnormal megakaryocyte development, and reduced body size.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	hemostasis, intracellular mRNA localization, ...
Component	dendrite, neuronal cell body
Function	mRNA 3'-UTR binding

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (201)    Tissues (118)    Images (52)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	122
In situ reporter (knock in)	14
Northern blot	8
RT-PCR	57

cDNA source data(54)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(60) cDNA(55) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000000552 (Evidence)
Entrez Gene	29813 (Evidence)
UniGene	14099
DFCI	TC1580418
DoTS	DT.101366409, DT.527937
NIA Mouse Gene Index	U036712
Consensus CDS Project	CCDS49743.1
International Mouse Knockout Project Status	Zfp385a

Sequences

Length	Strain/Species
genomic	29813	NCBI Gene Model | MGI Sequence Detail	26192	C57BL/6J
transcript	NM_013866	RefSeq | MGI Sequence Detail	2320	C57BL/6
polypeptide	NP_038894	RefSeq | MGI Sequence Detail	386	C57BL/6

All sequences(19) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(61 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR003604	Zinc finger, U1-type
Protein Ontology	PR:000017859	zinc finger protein 385A

References

(Earliest) J:58923 Hidaka M, et al., Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells. Mech Dev. 2000 Jan;90(1):3-15
(Latest) J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
All references(39)