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Bag3 Gene Detail
Summary
  • Symbol
    Bag3
  • Name
    BCL2-associated athanogene 3
  • Synonyms
    Bcl-2-interacting death suppressor, Bis
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352493
    NCBI Gene: 29810
Location & Maps
more
  • Sequence Map
    Chr7:128523583-128546977 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23395 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    BAG3, BCL2 associated athanogene 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BAG3, BCL2 associated athanogene 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BAG-3, BIS, CAIR-1, MFM6
  • Links
    NCBI Gene ID: 9531
    neXtProt AC: NX_O95817

  • Chr Location
    10q25.2-q26.2; chr10:119651347-119677819 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human BAG3 associations

Human Disease Mouse Models
       Cardiomyopathy, Dilated, 1hh; CMD1HH   OMIM: 613881
Myopathy, Myofibrillar, 6; MFM6   OMIM: 612954
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Gene trapped
    7
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit postnatal lethality, growth retardation, cardiomyocyte and skeletal myocyte degeneration, and pulmonary edema. Mice homozygous for a null allele also exhibit postnatal lethality and growth retardation but lack the myocyte degeneration phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030847 Ensembl Gene Model | MGI Sequence Detail 23395 C57BL/6J ±  kb
transcript ENSMUST00000033136 Ensembl | MGI Sequence Detail 2591 Not Applicable  
polypeptide ENSMUSP00000033136 Ensembl | MGI Sequence Detail 577 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    167 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    cDNA 60

    Microarray probesets 5
Other
Accession IDs
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MGI:2141804
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Gene Ontology 11
    Phenotypes 15
  • Earliest
    J:58551 Lee JH, et al., Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene. 1999 Nov 4;18(46):6183-90
  • Latest
    J:227905 Rosati A, et al., BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages. Nat Commun. 2015;6:8695

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory