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Bag3
Gene Detail
Symbol

Name
ID
Bag3
BCL2-associated athanogene 3
MGI:1352493
Synonyms
Bcl-2-interacting death suppressor, Bis
Feature Type
protein coding gene
Genetic Map
Chromosome 7
70.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:128523583-128546977 bp, + strand
From Ensembl annotation of GRCm38

  23395 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3162  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: BAG3
Protein SuperFamily: BAG family molecular chaperone regulator 3
Gene Tree: Bag3

Human
homologs
BAG3, Bcl2-associated athanogene 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9531
neXtProt AC: NX_O95817

Human Synonyms: BAG-3, BIS, CAIR-1, MFM6

Human Chr (Location): 10q25.2-q26.2; chr10:119651347-119677819 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human BAG3

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit postnatal lethality, growth retardation, cardiomyocyte and skeletal myocyte degeneration, and pulmonary edema. Mice homozygous for a null allele also exhibit postnatal lethality and growth retardation but lack the myocyte degeneration phenotype.
 
Interactions
Bag3 interacts with 126 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process apoptotic process, cellular response to mechanical stimulus, ...
Component cytoplasm, cytosol, ...
Function chaperone binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (5)    Tissues (5)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 5
cDNA source data(59)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase bag3    NEW 
Molecular
reagents
All nucleic(60) cDNA(60)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000030847 (Evidence)
Entrez Gene 29810 (Evidence)
UniGene 84073
DFCI TC1772887, TC1575511
DoTS DT.94335482, DT.531549
NIA Mouse Gene Index U008833
PDB 1UK5
Consensus CDS Project CCDS21898.1
International Mouse Phenotyping Consortium Status Bag3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030847 Ensembl Gene Model | MGI Sequence Detail 23395 C57BL/6J ±  kb
transcript ENSMUST00000033136 Ensembl | MGI Sequence Detail 2591 Not Applicable 
polypeptide ENSMUSP00000033136 Ensembl | MGI Sequence Detail 577 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(167 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003103 BAG domain
InterPro IPR001202 WW domain
Protein Ontology PR:000004621 BAG family molecular chaperone regulator 3
References
(Earliest) J:58551 Lee JH, et al., Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene. 1999 Nov 4;18(46):6183-90
(Latest) J:206488 Lim JH, et al., Aggravation of diabetic nephropathy in BCL-2 interacting cell death suppressor (BIS)-haploinsufficient mice together with impaired induction of superoxide dismutase (SOD) activity. Diabetologia. 2014 Jan;57(1):214-23
All references(49)
Other
accession IDs
MGI:2141804

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory