Bag3
Gene Detail

Symbol Name ID

Bag3 BCL2-associated athanogene 3 MGI:1352493

Synonyms

Bcl-2-interacting death suppressor, Bis

Feature Type

protein coding gene

Genetic Map

Chromosome 7

70.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:128523583-128546977 bp, + strand From Ensembl annotation of GRCm38   23395 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3162  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: BAG family molecular chaperone regulator 3
Gene Tree: Bag3

Human homologs

Human Homolog		BAG3, Bcl2-associated athanogene 3
NCBI Gene ID		9531
neXtProt AC		NX_O95817
Human Synonyms		BAG-3, BIS, CAIR-1
Human Chr (Location)		10q25.2-q26.2; chr10:121410882-121437331 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human BAG3

Alleles and phenotypes

All alleles(11) : Targeted(4) Gene trapped(7)
 

Mice homozygous for a gene trap allele exhibit postnatal lethality, growth retardation, cardiomyocyte and skeletal myocyte degeneration, and pulmonary edema. Mice homozygous for a null allele also exhibit postnatal lethality and growth retardation but lack the myocyte degeneration phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	apoptotic process, cellular response to mechanical stimulus, ...
Component	cytoplasm, cytosol, ...
Function	chaperone binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (5)    Tissues (5)    Images (1)
Theiler Stages: 17, 22, 26

Assay Type	Results
Western blot	5

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(11)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000030847 (Evidence)
Entrez Gene	29810 (Evidence)
DFCI	TC1575511, TC1772887
DoTS	DT.531549, DT.94335482
NIA Mouse Gene Index	U008833
PDB	1UK5
Consensus CDS Project	CCDS21898.1
International Mouse Knockout Project Status	Bag3

Sequences

Length	Strain/Species
genomic	ENSMUSG00000030847	Ensembl Gene Model | MGI Sequence Detail	23395	C57BL/6J
transcript	ENSMUST00000033136	Ensembl | MGI Sequence Detail	2591	Not Applicable
polypeptide	ENSMUSP00000033136	Ensembl | MGI Sequence Detail	577	Not Applicable

All sequences(35) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(97 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003103	BAG domain
InterPro	IPR001202	WW domain
Protein Ontology	PR:000004621	BAG family molecular chaperone regulator 3

References

(Earliest) J:58551 Lee JH, et al., Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene. 1999 Nov 4;18(46):6183-90
(Latest) J:187985 Cho KO, et al., Decreased vulnerability of hippocampal neurons after neonatal hypoxia-ischemia in bis-deficient mice. Glia. 2012 Dec;60(12):1915-29
All references(45)

Other accession IDs

MGI:2141804