About   Help   FAQ
Bag3 Gene Detail
Summary
  • Symbol
    Bag3
  • Name
    BCL2-associated athanogene 3
  • Synonyms
    Bcl-2-interacting death suppressor, Bis
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352493
    NCBI Gene: 29810
  • Gene Overview
    MyGene.info: BAG3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:128523616-128546981 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23366 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 70.26 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BAG3, BCL2 associated athanogene 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BAG3, BCL2 associated athanogene 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BAG-3, BIS, CAIR-1, MFM6
  • Links
    NCBI Gene ID: 9531
    neXtProt AC: NX_O95817
    UniProt: O95817

  • Chr Location
    10q26.11; chr10:119651347-119677819 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Bag3 mouse models; 2 with human BAG3 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 6 alleles in 8 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit postnatal lethality, growth retardation, cardiomyocyte and skeletal myocyte degeneration, and pulmonary edema. Mice homozygous for a null allele also exhibit postnatal lethality and growth retardation but lack the myocyte degeneration phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000058717 VEGA Gene Model | MGI Sequence Detail 23366 C57BL/6J ±  kb
    transcript OTTMUST00000144242 VEGA | MGI Sequence Detail 2562 Not Applicable  
    polypeptide OTTMUSP00000075216 VEGA | MGI Sequence Detail 577 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      167 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 60

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141804
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 11
      Phenotypes 19
    • Earliest
      J:58551 Lee JH, et al., Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene. 1999 Nov 4;18(46):6183-90
    • Latest
      J:256726 Cao YL, et al., A role of BAG3 in regulating SNCA/alpha-synuclein clearance via selective macroautophagy. Neurobiol Aging. 2017 Dec;60:104-115

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory