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Mga Gene Detail
Summary
  • Symbol
    Mga
  • Name
    MAX gene associated
  • Synonyms
    C130042M01Rik, D030062C11Rik, Mad5, Mga
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352483
    NCBI Gene: 29808
Location & Maps
more
  • Sequence Map
    Chr2:119897228-119967749 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      70522 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 59.97 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MGA, MGA, MAX dimerization protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MGA, MGA, MAX dimerization protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAD5, MXD5
  • Links
    NCBI Gene ID: 23269
    neXtProt AC: NX_Q8IWI9

  • Chr Location
    15q15.1; chr15:41621232-41769943 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 49351
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MGA
  • Gene Tree
    Mga
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    137
  • Chemically induced (other)
    1
  • Gene trapped
    135
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Mga
  • Incidental Mutations
Embryos homozygous for a gene trap allele die shortly after implantation due to defective development of the inner cell mass (ICM) and the epiblast. ICM derivatives fail to develop past E4.5 and show increased apoptosis but no change in cell proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015288 VEGA Gene Model | MGI Sequence Detail 70522 C57BL/6J ±  kb
transcript OTTMUST00000036232 VEGA | MGI Sequence Detail 11982 Not Applicable  
polypeptide OTTMUSP00000016277 VEGA | MGI Sequence Detail 3003 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    453 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 29
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
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MGI:2139266, MGI:2139508, MGI:2441880, MGI:2441937
References
more
  • Summaries
    All 42
    Developmental Gene Expression 10
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:59131 Hurlin PJ, et al., Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif. EMBO J. 1999 Dec 15;18(24):7019-28
  • Latest
    J:217679 Washkowitz AJ, et al., Mga is essential for the survival of pluripotent cells during peri-implantation development. Development. 2015 Jan 1;142(1):31-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory