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Mga Gene Detail
Summary
  • Symbol
    Mga
  • Name
    MAX gene associated
  • Synonyms
    C130042M01Rik, D030062C11Rik, Mad5, Mga
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352483
    NCBI Gene: 29808
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:119897228-119967749 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      70522 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 59.97 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MGA, MGA, MAX dimerization protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MGA, MGA, MAX dimerization protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAD5, MXD5
  • Links
    NCBI Gene ID: 23269
    neXtProt AC: NX_Q8IWI9
    UniProt: Q8IWI9

  • Chr Location
    15q15.1; chr15:41621139-41769943 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 49351
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MGA
  • Gene Tree
    Mga
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a gene trap allele die shortly after implantation due to defective development of the inner cell mass (ICM) and the epiblast. ICM derivatives fail to develop past E4.5 and show increased apoptosis but no change in cell proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000015288 VEGA Gene Model | MGI Sequence Detail 70522 C57BL/6J ±  kb
    transcript OTTMUST00000036232 VEGA | MGI Sequence Detail 11982 Not Applicable  
    polypeptide OTTMUSP00000016277 VEGA | MGI Sequence Detail 3003 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      453 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR032060 Domain of unknown function DUF4801
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR037935 MAX gene-associated protein
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR008967 p53-like transcription factor, DNA-binding
      IPR036960 T-box superfamily
      IPR001699 Transcription factor, T-box
      IPR018186 Transcription factor, T-box, conserved site
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 29
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2139266, MGI:2139508, MGI:2441880, MGI:2441937
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 10
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:260418 Burn SF, et al., Postimplantation Mga expression and embryonic lethality of two gene-trap alleles. Gene Expr Patterns. 2018 Jan;27(None):31-35

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory