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Igfbp7 Gene Detail
Summary
  • Symbol
    Igfbp7
  • Name
    insulin-like growth factor binding protein 7
  • Synonyms
    AGM, Fstl2, mac25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352480
    NCBI Gene: 29817
Location & Maps
more
  • Sequence Map
    Chr5:77349240-77408041 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      58802 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IGFBP7, insulin like growth factor binding protein 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IGFBP7, insulin like growth factor binding protein 7
    Orthology source: HomoloGene
  • Synonyms
    AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF
  • Links
    NCBI Gene ID: 3490
    neXtProt AC: NX_Q16270

  • Chr Location
    4q12; chr4:57031071-57110385 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IGFBP7 associations

Human Disease Mouse Models
       Retinal Arterial Macroaneurysm with Supravalvular Pulmonic Stenosis;   OMIM: 614224
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    2
  • Gene trapped
    3
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    3 involving Igfbp7
  • Incidental Mutations
Mice homozygous for a null allele exhibit retarded mammary gland developmental in virgin and adult females, reduced mammary gland size and alveolar density during pregnancy, precocious involution in lactating mammary glands, and abnormal milk composition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056133 VEGA Gene Model | MGI Sequence Detail 58802 C57BL/6J ±  kb
transcript OTTMUST00000138802 VEGA | MGI Sequence Detail 1200 Not Applicable  
polypeptide OTTMUSP00000072923 VEGA | MGI Sequence Detail 313 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    481 from dbSNP Build 137
Protein
Information
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  • UniProt
    7 Sequences
  • InterPro Domains
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR013098 Immunoglobulin I-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR000867 Insulin-like growth factor-binding protein, IGFBP
    IPR011390 Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25
    IPR002350 Kazal domain
Molecular
Reagents
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  • All nucleic 22
    Genomic 1
    cDNA 17
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-37071, MGI:108035
References
more
  • Summaries
    All 44
    Developmental Gene Expression 14
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:36297 Kato MV, et al., A follistatin-like gene, mac25, may act as a growth suppressor of osteosarcoma cells. Oncogene. 1996 Mar 21;12(6):1361-4
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory