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Igfbp7 Gene Detail
Summary
  • Symbol
    Igfbp7
  • Name
    insulin-like growth factor binding protein 7
  • Synonyms
    AGM, Fstl2, mac25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352480
    NCBI Gene: 29817
  • Gene Overview
    MyGene.info: IGFBP7
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:77349240-77408041 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      58802 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 41.71 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    IGFBP7, insulin like growth factor binding protein 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IGFBP7, insulin like growth factor binding protein 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF
  • Links
    NCBI Gene ID: 3490
    neXtProt AC: NX_Q16270
    UniProt: Q16270

  • Chr Location
    4q12; chr4:57031071-57110385 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit retarded mammary gland developmental in virgin and adult females, reduced mammary gland size and alveolar density during pregnancy, precocious involution in lactating mammary glands, and abnormal milk composition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000056133 VEGA Gene Model | MGI Sequence Detail 58802 C57BL/6J ±  kb
    transcript OTTMUST00000138802 VEGA | MGI Sequence Detail 1200 Not Applicable  
    polypeptide OTTMUSP00000072923 VEGA | MGI Sequence Detail 313 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      481 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • InterPro Domains
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003599 Immunoglobulin subtype
      IPR003598 Immunoglobulin subtype 2
      IPR000867 Insulin-like growth factor-binding protein, IGFBP
      IPR011390 Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25
      IPR002350 Kazal domain
      IPR036058 Kazal domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 18
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37071, MGI:108035
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 16
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:260151 Ito K, et al., Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters. Sci Rep. 2018 Jan 11;8(1):434

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory