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Igfbp7
Gene Detail
Symbol

Name
ID
Igfbp7
insulin-like growth factor binding protein 7
MGI:1352480
Synonyms
AGM, Fstl2, mac25
Feature Type
protein coding gene
Genetic Map
Chromosome 5
41.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:77349240-77408045 bp, - strand
From NCBI annotation of GRCm38

  58806 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1193  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: IGFBP-related protein, MAC25 type
Gene Tree: Igfbp7

Human
homologs
Human Homolog IGFBP7, insulin-like growth factor binding protein 7
NCBI Gene ID 3490
neXtProt AC  NX_Q16270
Human Synonyms  AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF
Human Chr (Location)  4q12; chr4:57031071-57110385 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human IGFBP7
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Igfbp7 interacts with 71 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell adhesion, inner ear development, ...
Component extracellular matrix, extracellular region, ...
Function growth factor binding, insulin-like growth factor binding
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (147)    Tissues (102)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 16
RNA in situ 55
In situ reporter (knock in) 25
RT-PCR 51
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(17) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000036256 (Evidence)
Entrez Gene29817 (Evidence)
DFCITC1572877, TC1650209, TC1624621, TC1703796
NIA Mouse Gene IndexU026333, U292156
Consensus CDS ProjectCCDS51529.1, CCDS51530.1
International Mouse Knockout Project StatusIgfbp7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 29817 NCBI Gene Model | MGI Sequence Detail 58806 C57BL/6J ±  kb
transcript NM_001159518 RefSeq | MGI Sequence Detail 1213 C57BL/6 
polypeptide Q61581 UniProt | EBI | MGI Sequence Detail 281 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(13)
Polymorphisms
SNPs within 2kb(481 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR000867 Insulin-like growth factor-binding protein, IGFBP
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR011390 Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25
InterPro IPR002350 Kazal domain
Protein Ontology PR:000008953 insulin-like growth factor-binding protein 7
Graphical View of Protein Domain Structure
References
(Earliest) J:36297 Kato MV, et al., A follistatin-like gene, mac25, may act as a growth suppressor of osteosarcoma cells. Oncogene. 1996 Mar 21;12(6):1361-4
(Latest) J:214095 Osipovich AB, et al., Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development. 2014 Aug;141(15):2939-49
All references(43)
Other
accession IDs
MGD-MRK-37071, MGI:108035

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory