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Nr2c1
Gene Detail
Symbol

Name
ID
Nr2c1
nuclear receptor subfamily 2, group C, member 1
MGI:1352465
Synonyms
4831444H07Rik, Eenr, TR2, Tr2-11
Feature Type
protein coding gene
Genetic Map
Chromosome 10
48.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:94148023-94197211 bp, + strand
From VEGA annotation of GRCm38

  49189 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55731  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: orphan nuclear receptor TR2/TR4
Gene Tree: Nr2c1

Human
homologs
Human Homolog NR2C1, nuclear receptor subfamily 2, group C, member 1
NCBI Gene ID 7181
neXtProt AC  NX_P13056
Human Synonyms  TR2
Human Chr (Location)  12q22; chr12:95020229-95073628 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(33) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation are viable, fertile and do not exhibit any defects in testis development or in spermatogenesis; no gross defects were detected in the central nervous system and normal motor neuron cell numbers were noted.
 
Interactions
Nr2c1 interacts with 292 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (14 records)
Data Summary: Results (236)    Tissues (174)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 209
Northern blot 18
RT-PCR 8
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(7) cDNA(17) Primer pair(2)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000022679 (Evidence)
Ensembl Gene ModelENSMUSG00000005897 (Evidence)
Entrez Gene22025 (Evidence)
NIA Mouse Gene IndexU011907, U243526
Consensus CDS ProjectCCDS24131.1
International Mouse Knockout Project StatusNr2c1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022679 VEGA Gene Model | MGI Sequence Detail 49189 C57BL/6J ±  kb
transcript OTTMUST00000054363 VEGA | MGI Sequence Detail 3732 Not Applicable 
polypeptide OTTMUSP00000025946 VEGA | MGI Sequence Detail 590 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(8) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(554 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011399 nuclear receptor subfamily 2 group C member 1
References
(Earliest) J:19511 Wei LN, et al., Identification of a new gene expressed specifically in early mouse embryos. Dev Growth Differ. 1994 APR;36(2):187-196
(Latest) J:185367 L'hote D, et al., Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles. Hum Mol Genet. 2012 Jul 15;21(14):3264-74
All references(60)
Other
accession IDs
MGD-MRK-26050, MGD-MRK-26100, MGI:104613, MGI:104660, MGI:2443924

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory