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Nr2c1 Gene Detail
Summary
  • Symbol
    Nr2c1
  • Name
    nuclear receptor subfamily 2, group C, member 1
  • Synonyms
    4831444H07Rik, Eenr, TR2, Tr2-11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352465
    NCBI Gene: 22025
  • Gene Overview
    MyGene.info: NR2C1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:94148023-94197211 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 48.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    564 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352465
protein coding gene Chr10:94147512-94197216 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017661
protein coding gene Chr10:95612167-95667412 (+)
A/J MGP_AJ_G0017640
protein coding gene Chr10:92261129-92310514 (+)
AKR/J MGP_AKRJ_G0017598
protein coding gene Chr10:94903081-94952991 (+)
BALB/cJ MGP_BALBcJ_G0017603
protein coding gene Chr10:92535506-92589303 (+)
C3H/HeJ MGP_C3HHeJ_G0017426
protein coding gene Chr10:94897843-94948432 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018060
protein coding gene Chr10:98766921-98820466 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015741
protein coding gene Chr10:87844640-87895224 (+)
CAST/EiJ MGP_CASTEiJ_G0016991
protein coding gene Chr10:94902521-94953364 (+)
CBA/J MGP_CBAJ_G0017395
protein coding gene Chr10:102851283-102911337 (+)
DBA/2J MGP_DBA2J_G0017501
protein coding gene Chr10:91355778-91405163 (+)
FVB/NJ MGP_FVBNJ_G0017493
protein coding gene Chr10:90595893-90645455 (+)
LP/J MGP_LPJ_G0017575
protein coding gene Chr10:96220503-96270674 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017524
protein coding gene Chr10:104113218-104165696 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018097
protein coding gene Chr10:94806058-94859522 (+)
PWK/PhJ MGP_PWKPhJ_G0016772
protein coding gene Chr10:91451711-91501578 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016560
protein coding gene Chr10:93604832-93665760 (+)
WSB/EiJ MGP_WSBEiJ_G0017050
protein coding gene Chr10:94771708-94822545 (+)



Homology
more
  • Human Ortholog
    NR2C1, nuclear receptor subfamily 2 group C member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NR2C1, nuclear receptor subfamily 2 group C member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TR2
  • Links
    NCBI Gene ID: 7181
    neXtProt AC: NX_P13056
    UniProt: P13056

  • Chr Location
    12q22; chr12:95020229-95073628 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable, fertile and do not exhibit any defects in testis development or in spermatogenesis; no gross defects were detected in the central nervous system and normal motor neuron cell numbers were noted.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005897 Ensembl Gene Model | MGI Sequence Detail 49189 C57BL/6J ±  kb
transcript ENSMUST00000105290 Ensembl | MGI Sequence Detail 3732 Not Applicable  
polypeptide ENSMUSP00000100927 Ensembl | MGI Sequence Detail 590 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011399 nuclear receptor subfamily 2 group C member 1
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR035500 Nuclear hormone receptor-like domain superfamily
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 33
    Genomic 7
    cDNA 20
    Primer pair 4
    Other 2

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-26050, MGD-MRK-26100, MGI:104613, MGI:104660, MGI:2443924
References
more
  • Summaries
    All 72
    Developmental Gene Expression 17
    Gene Ontology 11
    Phenotypes 19
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:248772 Olivares AM, et al., The nuclear hormone receptor gene Nr2c1 (Tr2) is a critical regulator of early retina cell patterning. Dev Biol. 2017 Sep 1;429(1):343-355

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory