About   Help   FAQ
Nr6a1
Gene Detail
Symbol

Name
ID
Nr6a1
nuclear receptor subfamily 6, group A, member 1
MGI:1352459
Synonyms
1700113M01Rik, Gcnf, NCNF
Feature Type
protein coding gene
Genetic Map
Chromosome 2
24.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:38723370-38927688 bp, - strand
From VEGA annotation of GRCm38

  204319 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36308  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nr6a1

Human
homologs
Human Homolog NR6A1, nuclear receptor subfamily 6, group A, member 1
NCBI Gene ID 2649
neXtProt AC  NX_Q15406
Human Synonyms  CT150, GCNF, GCNF1, hGCNF, hRTR, NR61, RTR
Human Chr (Location)  9q33.3; chr9:124517275-124771310 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(155) : Gene trapped(147) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations have cardiovascular abnormalities, defective trunk development, impaired somite formation, failure to turn, open neural tube and hindgut, protrusion of the tailbud outside the yolk sac and die by embryonic day 10.5.
 
Interactions
Nr6a1 interacts with 465 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cell differentiation, multicellular organismal development, ...
Component nucleus, transcription factor complex
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (124)    Tissues (75)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 80
RT-PCR 44
cDNA source data(89)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(94) cDNA(91) Primer pair(2) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000012347 (Evidence)
Ensembl Gene ModelENSMUSG00000063972 (Evidence)
Entrez Gene14536 (Evidence)
UniGene439703
DFCITC1753924, TC1723030, TC1601820, TC1577952
DoTSDT.101330778, DT.87048448, DT.55150092, DT.530109, DT.103570139, DT.91325486
NIA Mouse Gene IndexU022570
Consensus CDS ProjectCCDS16012.1, CCDS50581.1
International Mouse Knockout Project StatusNr6a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012347 VEGA Gene Model | MGI Sequence Detail 204319 C57BL/6J ±  kb
transcript OTTMUST00000029378 VEGA | MGI Sequence Detail 6334 Not Applicable 
polypeptide OTTMUSP00000013244 VEGA | MGI Sequence Detail 495 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(14) UniProt(3)
Polymorphisms
SNPs within 2kb(376 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011413 nuclear receptor subfamily 6 group A member 1
References
(Earliest) J:21389 Chen F, et al., Cloning of a novel orphan receptor (GCNF) expressed during germ cell development. Mol Endocrinol. 1994 Oct;8(10):1434-44
(Latest) J:204241 Okumura LM, et al., The ligand binding domain of GCNF is not required for repression of pluripotency genes in mouse fetal ovarian germ cells. PLoS One. 2013;8(6):e66062
All references(80)
Other
accession IDs
MGD-MRK-19678, MGI:102771, MGI:1923917

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory