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Nr6a1 Gene Detail
Summary
  • Symbol
    Nr6a1
  • Name
    nuclear receptor subfamily 6, group A, member 1
  • Synonyms
    1700113M01Rik, Gcnf, NCNF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352459
    NCBI Gene: 14536
  • Gene Overview
    MyGene.info: NR6A1
Location & Maps
more
  • Sequence Map
    Chr2:38723370-38927688 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      204319 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NR6A1, nuclear receptor subfamily 6 group A member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NR6A1, nuclear receptor subfamily 6 group A member 1
    Orthology source: HomoloGene
  • Synonyms
    CT150, GCNF, GCNF1, hGCNF, hRTR, NR61, RTR
  • Links
    NCBI Gene ID: 2649
    neXtProt AC: NX_Q15406

  • Chr Location
    9q33.3; chr9:124517275-124771310 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 36308
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NR6A1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    62 phenotypes from 7 alleles in 4 genetic backgrounds
    1 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations have cardiovascular abnormalities, defective trunk development, impaired somite formation, failure to turn, open neural tube and hindgut, protrusion of the tailbud outside the yolk sac and die by embryonic day 10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012347 VEGA Gene Model | MGI Sequence Detail 204319 C57BL/6J ±  kb
transcript OTTMUST00000029378 VEGA | MGI Sequence Detail 6334 Not Applicable  
polypeptide OTTMUSP00000013244 VEGA | MGI Sequence Detail 495 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    374 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011413 nuclear receptor subfamily 6 group A member 1
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 94
    cDNA 91
    Primer pair 2
    Other 1

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-19678, MGI:102771, MGI:1923917
References
more
  • Summaries
    All 79
    Developmental Gene Expression 29
    Gene Ontology 10
    Phenotypes 20
  • Earliest
    J:21389 Chen F, et al., Cloning of a novel orphan receptor (GCNF) expressed during germ cell development. Mol Endocrinol. 1994 Oct;8(10):1434-44
  • Latest
    J:221000 Sabour D, et al., Germ cell nuclear factor regulates gametogenesis in developing gonads. PLoS One. 2014;9(8):e103985

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory