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Nr4a3 Gene Detail
Summary
  • Symbol
    Nr4a3
  • Name
    nuclear receptor subfamily 4, group A, member 3
  • Synonyms
    MINOR, Nor1, NOR-1, TEC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352457
    NCBI Gene: 18124
  • Alliance
    gene page
  • Transcription Start Sites
    44 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:48045153-48086447 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 26.07 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    234 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352457
 protein coding gene Chr4:48045098-48086447 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028270
 protein coding gene Chr4:46460579-46502995 (+)
A/J MGP_AJ_G0028229
 protein coding gene Chr4:44721846-44763672 (+)
AKR/J MGP_AKRJ_G0028179
 protein coding gene Chr4:45860036-45901247 (+)
BALB/cJ MGP_BALBcJ_G0028249
 protein coding gene Chr4:44835915-44877207 (+)
C3H/HeJ MGP_C3HHeJ_G0027970
 protein coding gene Chr4:46430589-46473360 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028690
 protein coding gene Chr4:48142176-48183404 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025999
 protein coding gene Chr4:42077867-42119037 (+)
CAST/EiJ MGP_CASTEiJ_G0027409
 protein coding gene Chr4:46024627-46065881 (+)
CBA/J MGP_CBAJ_G0027936
 protein coding gene Chr4:49692734-49738862 (+)
DBA/2J MGP_DBA2J_G0028086
 protein coding gene Chr4:44609087-44650735 (+)
FVB/NJ MGP_FVBNJ_G0028053
 protein coding gene Chr4:43877072-43918535 (+)
LP/J MGP_LPJ_G0028185
 protein coding gene Chr4:46508709-46551206 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028077
 protein coding gene Chr4:52693144-52740757 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028725
 protein coding gene Chr4:46056317-46098492 (+)
PWK/PhJ MGP_PWKPhJ_G0027134
 protein coding gene Chr4:44727966-44769565 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026962
 protein coding gene Chr4:45579829-45618803 (+)
WSB/EiJ MGP_WSBEiJ_G0027487
 protein coding gene Chr4:45988640-46032300 (+)



Homology
more
  • Human Ortholog
    NR4A3, nuclear receptor subfamily 4 group A member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR4A3, nuclear receptor subfamily 4 group A member 3
  • Synonyms
    CHN, CSMF, MINOR, NOR1
  • Links
    NCBI Gene ID: 8013
    neXtProt AC: NX_Q92570
    UniProt: Q92570

  • Chr Location
    9q31.1; chr9:99821855-99866891 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NR4A3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    26 phenotypes from multigenic genotypes
    1 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit defects in the semicircular canals of the inner ear and bidirectional circling behavior. Mice homozygous for another null allele display embryonic lethality with impaired cell migration during gastrulation. Homozygous KO also decreases apoptosis and increases proliferation of B cell stimulated by a single antigen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    881
  • Tissues
    93
  • cDNA Data
    15
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028341 Ensembl Gene Model | MGI Sequence Detail 41295 C57BL/6J ±  kb
    transcript ENSMUST00000153369 Ensembl | MGI Sequence Detail 5068 Not Applicable  
    polypeptide ENSMUSP00000121455 Ensembl | MGI Sequence Detail 657 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000011410 nuclear receptor subfamily 4 group A member 3
      (term hierarchy)
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR003070 Nuclear receptor subfamily 4 group A member 1-3
      IPR003072 Nuclear receptor subfamily 4 group A member 3
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 2
      cDNA 15
      Primer pair 6
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37462, MGI:108419, MGI:2140333
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 25
      Diseases 1
      Gene Ontology 26
      Phenotypes 30
    • Earliest
      J:33283 Law SW, et al., Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol. 1992 Dec;6(12):2129-35
    • Latest
      J:322007 Sekiya T, et al., Regulation of peripheral Th/Treg differentiation and suppression of airway inflammation by Nr4a transcription factors. iScience. 2021 Mar 19;24(3):102166
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory