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Nr4a3
Gene Detail
Symbol

Name
ID
Nr4a3
nuclear receptor subfamily 4, group A, member 3
MGI:1352457
Synonyms
MINOR, Nor1, NOR-1, TEC
Feature Type
protein coding gene
Genetic Map
Chromosome 4
26.07 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:48045153-48086447 bp, + strand
From VEGA annotation of GRCm38

  41295 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5074  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: nerve growth factor IB-like nuclear receptor
Gene Tree: Nr4a3

Human
homologs
Human Homolog NR4A3, nuclear receptor subfamily 4, group A, member 3
NCBI Gene ID 8013
neXtProt AC  NX_Q92570
Human Synonyms  CHN, CSMF, MINOR, NOR1, TEC
Human Chr (Location)  9q22; chr9:99821855-99866891 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NR4A3
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit defects in the semicircular canals of the inner ear and bidirectional circling behavior. Mice homozygous for another null allele display embryonic lethality with impaired cell migration during gastrulation.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Nr4a3 interacts with 380 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (14 records)
Data Summary: Results (140)    Tissues (70)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 89
Northern blot 36
RT-PCR 15
cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(14) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006813 (Evidence)
Ensembl Gene ModelENSMUSG00000028341 (Evidence)
Entrez Gene18124 (Evidence)
DFCITC1598199, TC1652067, TC1656032
DoTSDT.528080, DT.110825814, DT.103560291
NIA Mouse Gene IndexU063026
Consensus CDS ProjectCCDS18163.1
International Mouse Knockout Project StatusNr4a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006813 VEGA Gene Model | MGI Sequence Detail 41295 C57BL/6J ±  kb
transcript OTTMUST00000057710 VEGA | MGI Sequence Detail 5068 Not Applicable 
polypeptide OTTMUSP00000027867 VEGA | MGI Sequence Detail 657 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(10) UniProt(7)
Polymorphisms
SNPs within 2kb(235 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR003070 Orphan nuclear receptor
InterPro IPR003072 Orphan nuclear receptor, NOR1 type
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011410 nuclear receptor subfamily 4 group A member 3
References
(Earliest) J:33283 Law SW, et al., Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol. 1992 Dec;6(12):2129-35
(Latest) J:205020 Kim SG, et al., Control of energy balance by hypothalamic gene circuitry involving two nuclear receptors, neuron-derived orphan receptor 1 and glucocorticoid receptor. Mol Cell Biol. 2013 Oct;33(19):3826-34
All references(60)
Other
accession IDs
MGD-MRK-37462, MGI:108419, MGI:2140333

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory