Nr4a3 MGI Mouse Gene Detail - MGI:1352457 - nuclear receptor subfamily 4, group A, member 3

Symbol

Nr4a3
Name

nuclear receptor subfamily 4, group A, member 3
Synonyms

MINOR, Nor1, NOR-1, TEC

Feature Type

protein coding gene
IDs

MGI:1352457
NCBI Gene: 18124
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr4:48045153-48086447 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 26.07 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

234 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352457	protein coding gene	Chr4:48045078-48086447 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028270	protein coding gene	Chr4:46460579-46502995 (+)
A/J	MGP_AJ_G0028229	protein coding gene	Chr4:44721846-44763672 (+)
AKR/J	MGP_AKRJ_G0028179	protein coding gene	Chr4:45860036-45901247 (+)
BALB/cJ	MGP_BALBcJ_G0028249	protein coding gene	Chr4:44835915-44877207 (+)
C3H/HeJ	MGP_C3HHeJ_G0027970	protein coding gene	Chr4:46430589-46473360 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028690	protein coding gene	Chr4:48142176-48183404 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025999	protein coding gene	Chr4:42077867-42119037 (+)
CAST/EiJ	MGP_CASTEiJ_G0027409	protein coding gene	Chr4:46024627-46065881 (+)
CBA/J	MGP_CBAJ_G0027936	protein coding gene	Chr4:49692734-49738862 (+)
DBA/2J	MGP_DBA2J_G0028086	protein coding gene	Chr4:44609087-44650735 (+)
FVB/NJ	MGP_FVBNJ_G0028053	protein coding gene	Chr4:43877072-43918535 (+)
LP/J	MGP_LPJ_G0028185	protein coding gene	Chr4:46508709-46551206 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028077	protein coding gene	Chr4:52693144-52740757 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028725	protein coding gene	Chr4:46056317-46098492 (+)
PWK/PhJ	MGP_PWKPhJ_G0027134	protein coding gene	Chr4:44727966-44769565 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026962	protein coding gene	Chr4:45579829-45618803 (+)
WSB/EiJ	MGP_WSBEiJ_G0027487	protein coding gene	Chr4:45988640-46032300 (+)

Human Ortholog

NR4A3, nuclear receptor subfamily 4 group A member 3

Vertebrate Orthologs

10

Human Ortholog

NR4A3, nuclear receptor subfamily 4 group A member 3
Orthology source: HomoloGene, HGNC
Synonyms

CHN, CSMF, MINOR, NOR1, TEC
Links

HGNC:7982

NCBI Gene ID: 8013

neXtProt AC: NX_Q92570

UniProt: Q92570
Chr Location

9q31.1; chr9:99821855-99866893 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 5074
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NR4A3
Protein SuperFamily

nerve growth factor IB-like nuclear receptor
Gene Tree

Nr4a3

Diseases

1 with human NR4A3 associations

				Human Disease	Mouse Models
				extraskeletal myxoid chondrosarcoma IDs extraskeletal myxoid chondrosarcoma DOID:6496 MESH:C563195 NCI:C27502 OMIM:612237 UMLS_CUI:C1275278

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

22 phenotypes from 2 alleles in 2 genetic backgrounds
23 phenotypes from multigenic genotypes
1 images
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

2 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit defects in the semicircular canals of the inner ear and bidirectional circling behavior. Mice homozygous for another null allele display embryonic lethality with impaired cell migration during gastrulation.

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All GO Annotations

75
GO References

25

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

782
Tissues

78
cDNA Data

15
Literature Summary

21

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NR4A3

Xenbase nr4a3

ZFIN nr4a3

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Nr4a3 interacts with 379 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

56
RefSeq

12
UniProt

4
CCDS

CCDS18163.1

Ensembl

ENSMUSG00000028341 (Evidence)
NCBI Gene

18124

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028341	Ensembl Gene Model \| MGI Sequence Detail	41295	C57BL/6J	± kb
transcript	ENSMUST00000153369	Ensembl \| MGI Sequence Detail	5068	Not Applicable
polypeptide	ENSMUSP00000121455	Ensembl \| MGI Sequence Detail	657	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011410 nuclear receptor subfamily 4 group A member 3

(term hierarchy)
InterPro Domains

IPR001723 Nuclear hormone receptor

IPR000536 Nuclear hormone receptor, ligand-binding domain

IPR035500 Nuclear hormone receptor-like domain superfamily

IPR003070 Orphan nuclear receptor

IPR003072 Orphan nuclear receptor, NOR1 type

IPR013088 Zinc finger, NHR/GATA-type

IPR001628 Zinc finger, nuclear hormone receptor-type

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All nucleic 22

Genomic 2

cDNA 15

Primer pair 4

Other 1

Microarray probesets 4

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MGD-MRK-37462, MGI:108419, MGI:2140333

Summaries

All 89

Developmental Gene Expression 21

Diseases 1

Gene Ontology 25

Phenotypes 22
Earliest

J:33283 Law SW, et al., Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol. 1992 Dec;6(12):2129-35
Latest

J:279591 Close AF, et al., The orphan nuclear receptor Nor1/Nr4a3 is a negative regulator of beta-cell mass. J Biol Chem. 2019 Mar 29;294(13):4889-4897

TSS for Nr4a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37187	Chr4:48045115-48045124 (+)	-33 bp
Tssr37188	Chr4:48045144-48045160 (+)	-1 bp
Tssr37189	Chr4:48045175-48045190 (+)	30 bp
Tssr37190	Chr4:48045230-48045238 (+)	81 bp
Tssr37191	Chr4:48045257-48045307 (+)	129 bp
Tssr37192	Chr4:48045324-48045333 (+)	176 bp
Tssr37193	Chr4:48045380-48045389 (+)	232 bp
Tssr37207	Chr4:48049026-48049063 (+)	3,892 bp
Tssr37208	Chr4:48049080-48049092 (+)	3,933 bp
Tssr37210	Chr4:48050777-48050781 (+)	5,626 bp
Tssr37211	Chr4:48051254-48051268 (+)	6,108 bp
Tssr37212	Chr4:48051277-48051297 (+)	6,134 bp
Tssr37213	Chr4:48051367-48051372 (+)	6,217 bp
Tssr37214	Chr4:48051379-48051396 (+)	6,235 bp
Tssr37215	Chr4:48051430-48051444 (+)	6,284 bp
Tssr37216	Chr4:48051523-48051535 (+)	6,376 bp
Tssr37220	Chr4:48083806-48083821 (+)	38,661 bp
Tssr37221	Chr4:48084222-48084242 (+)	39,079 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/19/2020 MGI 6.15