Nr4a3
Gene Detail

Symbol

Name
ID

Nr4a3
nuclear receptor subfamily 4, group A, member 3
MGI:1352457

Synonyms

MINOR, Nor1, NOR-1, TEC

Feature Type

protein coding gene

Genetic Map

Chromosome 4
26.07 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:48045153-48086447 bp, + strand From VEGA annotation of GRCm38   41295 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:5074  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: nerve growth factor IB-like nuclear receptor
Gene Tree: Nr4a3

Human
homologs

Human Homolog		NR4A3, nuclear receptor subfamily 4, group A, member 3
NCBI Gene ID		8013
neXtProt AC		NX_Q92570
Human Synonyms		CHN, CSMF, MINOR, NOR1, TEC
Human Chr (Location)		9q22; chr9:99821855-99866891 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human NR4A3

Mutations,
alleles, and
phenotypes

All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null allele exhibit defects in the semicircular canals of the inner ear and bidirectional circling behavior. Mice homozygous for another null allele display embryonic lethality with impaired cell migration during gastrulation.

 
Mutations Annotated to Human Diseases (1)    Phenotype Images(1)

Interactions

Nr4a3 interacts with 380 markers (Mir1b, Mir7-1, Mir7-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (32 annotations)

Process	adult behavior, axon guidance, ...
Component	nucleus, transcription factor complex
Function	DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)

Data Summary: Results (140)    Tissues (70)    Images (31)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	89
Northern blot	36
RT-PCR	15

cDNA source data(14)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(19) Genomic(1) cDNA(14) Primer pair(3) Other(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000006813 (Evidence)
Ensembl Gene Model	ENSMUSG00000028341 (Evidence)
Entrez Gene	18124 (Evidence)
DFCI	TC1652067, TC1598199, TC1656032
DoTS	DT.103560291, DT.528080, DT.110825814
NIA Mouse Gene Index	U063026
Consensus CDS Project	CCDS18163.1
International Mouse Knockout Project Status	Nr4a3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006813	VEGA Gene Model | MGI Sequence Detail	41295	C57BL/6J
transcript	OTTMUST00000057710	VEGA | MGI Sequence Detail	5068	Not Applicable
polypeptide	OTTMUSP00000027867	VEGA | MGI Sequence Detail	657	Not Applicable

All sequences(53) RefSeq(10) UniProt(7)

Polymorphisms

SNPs within 2kb(235 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR003070	Orphan nuclear receptor
InterPro	IPR003072	Orphan nuclear receptor, NOR1 type
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000011410	nuclear receptor subfamily 4 group A member 3

References

(Earliest) J:33283 Law SW, et al., Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol. 1992 Dec;6(12):2129-35
(Latest) J:205020 Kim SG, et al., Control of energy balance by hypothalamic gene circuitry involving two nuclear receptors, neuron-derived orphan receptor 1 and glucocorticoid receptor. Mol Cell Biol. 2013 Oct;33(19):3826-34
All references(60)

Other
accession IDs

MGD-MRK-37462, MGI:108419, MGI:2140333