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Nr4a3 Gene Detail
Summary
  • Symbol
    Nr4a3
  • Name
    nuclear receptor subfamily 4, group A, member 3
  • Synonyms
    MINOR, Nor1, NOR-1, TEC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352457
    NCBI Gene: 18124
Location & Maps
more
  • Sequence Map
    Chr4:48045153-48086447 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      41295 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 26.07 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NR4A3, nuclear receptor subfamily 4 group A member 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NR4A3, nuclear receptor subfamily 4 group A member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHN, CSMF, MINOR, NOR1, TEC
  • Links
    NCBI Gene ID: 8013
    neXtProt AC: NX_Q92570

  • Chr Location
    9q22; chr9:99821855-99866893 (+)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with human NR4A3 associations

Human Disease Mouse Models
       Chondrosarcoma, Extraskeletal Myxoid   OMIM: 612237
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotypes from multigenic genotypes
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit defects in the semicircular canals of the inner ear and bidirectional circling behavior. Mice homozygous for another null allele display embryonic lethality with impaired cell migration during gastrulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    70
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    142
  • Tissues
    72
  • cDNA Data
    14
  • Literature Summary
    15
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006813 VEGA Gene Model | MGI Sequence Detail 41295 C57BL/6J ±  kb
transcript OTTMUST00000057710 VEGA | MGI Sequence Detail 5068 Not Applicable  
polypeptide OTTMUSP00000027867 VEGA | MGI Sequence Detail 657 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    234 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000011410 nuclear receptor subfamily 4 group A member 3
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR003070 Orphan nuclear receptor
    IPR003072 Orphan nuclear receptor, NOR1 type
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 19
    Genomic 1
    cDNA 14
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-37462, MGI:108419, MGI:2140333
References
more
  • Summaries
    All 66
    Developmental Gene Expression 15
    Diseases 1
    Gene Ontology 24
    Phenotypes 15
  • Earliest
    J:33283 Law SW, et al., Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol. 1992 Dec;6(12):2129-35
  • Latest
    J:227557 Sekiya T, et al., Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells. J Exp Med. 2015 Sep 21;212(10):1623-40
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory