About   Help   FAQ
Nr4a3 Gene Detail
Summary
  • Symbol
    Nr4a3
  • Name
    nuclear receptor subfamily 4, group A, member 3
  • Synonyms
    MINOR, Nor1, NOR-1, TEC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352457
    NCBI Gene: 18124
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr4:48045153-48086447 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      41295 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 26.07 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NR4A3, nuclear receptor subfamily 4 group A member 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NR4A3, nuclear receptor subfamily 4 group A member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHN, CSMF, MINOR, NOR1, TEC
  • Links
    NCBI Gene ID: 8013
    neXtProt AC: NX_Q92570
    UniProt: Q92570

  • Chr Location
    9q31.1; chr9:99821855-99866893 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human NR4A3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotypes from multigenic genotypes
    1 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit defects in the semicircular canals of the inner ear and bidirectional circling behavior. Mice homozygous for another null allele display embryonic lethality with impaired cell migration during gastrulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    142
  • Tissues
    72
  • cDNA Data
    14
  • Literature Summary
    16
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006813 VEGA Gene Model | MGI Sequence Detail 41295 C57BL/6J ±  kb
transcript OTTMUST00000057710 VEGA | MGI Sequence Detail 5068 Not Applicable  
polypeptide OTTMUSP00000027867 VEGA | MGI Sequence Detail 657 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    234 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR035500 Nuclear hormone receptor-like domain superfamily
    IPR003070 Orphan nuclear receptor
    IPR003072 Orphan nuclear receptor, NOR1 type
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
less
  • All nucleic 19
    Genomic 1
    cDNA 14
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-37462, MGI:108419, MGI:2140333
References
more
  • Summaries
    All 77
    Developmental Gene Expression 16
    Diseases 1
    Gene Ontology 24
    Phenotypes 17
  • Earliest
    J:33283 Law SW, et al., Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol. 1992 Dec;6(12):2129-35
  • Latest
    J:251198 Nagaoka M, et al., The Orphan Nuclear Receptor NR4A3 Is Involved in the Function of Dendritic Cells. J Immunol. 2017 Oct 15;199(8):2958-2967
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory