Nr2f6 MGI Mouse Gene Detail - MGI:1352453 - nuclear receptor subfamily 2, group F, member 6

Nr2f6 Gene Detail

Symbol

Nr2f6
Name

nuclear receptor subfamily 2, group F, member 6
Synonyms

COUP-TF3, EAR2, Erbal2

Feature Type

protein coding gene
IDs

MGI:1352453
NCBI Gene: 13864
Gene Overview

MyGene.info: NR2F6
Alliance

gene page

Sequence Map

Chr8:71374123-71381960 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

7838 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.43 cM
Mapping Data

2 experiments

Human Ortholog

NR2F6, nuclear receptor subfamily 2 group F member 6

Vertebrate Orthologs

10

Human Ortholog

NR2F6, nuclear receptor subfamily 2 group F member 6
Orthology source: HomoloGene, HGNC
Synonyms

EAR2, EAR-2, ERBAL2
Links

HGNC:7977

NCBI Gene ID: 2063

neXtProt AC: NX_P10588

UniProt: P10588
Chr Location

19p13.11; chr19:17231885-17245342 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7706
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NR2F6
Protein SuperFamily

retinoic X receptor-like nuclear receptor
Gene Tree

Nr2f6

less

Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

2
Genomic Mutations

1 involving Nr2f6
Incidental Mutations

CvDC
Find Mice (IMSR)

2 strains or lines available

Mice homozygous for a knock-out allele exhibit partial agenesis of the locus coeruleus, increased thermal nociception, and defective circadian behavior including a delayed entrainment to shifted light-dark cycles and reduced anticipatory locomotor activity in restricted feeding experiments.

less

All GO Annotations

21
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

301
Tissues

213
cDNA Data

17
Literature Summary

19

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nr2f6

ZFIN nr2f6a, nr2f6b

less

Nr2f6 interacts with 61 markers (Mir7-1, Mir17, Mir20b, ...) View All

less

All Sequences

52
RefSeq

8
UniProt

4
CCDS

CCDS22392.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000022854	VEGA Gene Model \| MGI Sequence Detail	7838	C57BL/6J	± kb
transcript	OTTMUST00000054954	VEGA \| MGI Sequence Detail	2218	Not Applicable
polypeptide	OTTMUSP00000026253	VEGA \| MGI Sequence Detail	390	Not Applicable

less

SNPs within 2kb

76 from dbSNP Build 142

less

UniProt

4 Sequences
Protein Ontology

PR:000029648 nuclear receptor subfamily 2 group F member 6

(term hierarchy)
InterPro Domains

IPR001723 Nuclear hormone receptor

IPR000536 Nuclear hormone receptor, ligand-binding domain

IPR035500 Nuclear hormone receptor-like domain superfamily

IPR003068 Transcription factor COUP

IPR013088 Zinc finger, NHR/GATA-type

IPR001628 Zinc finger, nuclear hormone receptor-type

less

All nucleic 25

cDNA 18

Primer pair 4

Other 3

Microarray probesets 4

less

MGD-MRK-16308, MGI:2142737, MGI:99530

Summaries

All 55

Developmental Gene Expression 19

Gene Ontology 7

Phenotypes 9
Earliest

J:18334 Barnhart KM, et al., The sequence of a murine cDNA encoding Ear-2, a nuclear orphan receptor. Gene. 1994 May 16;142(2):313-4
Latest

J:265472 Klepsch V, et al., Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade. Nat Commun. 2018 Apr 18;9(1):1538

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/09/2018 MGI 6.12