Nr2f6 MGI Mouse Gene Detail - MGI:1352453 - nuclear receptor subfamily 2, group F, member 6

Symbol

Nr2f6
Name

nuclear receptor subfamily 2, group F, member 6
Synonyms

COUP-TF3, EAR2, Erbal2

Feature Type

protein coding gene
IDs

MGI:1352453
NCBI Gene: 13864
Gene Overview

MyGene.info: NR2F6
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:71374123-71381960 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.43 cM
Mapping Data

2 experiments

SNPs within 2kb

76 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352453	protein coding gene	Chr8:71374118-71381967 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033741	protein coding gene	Chr8:71763805-71771637 (-)
A/J	MGP_AJ_G0033724	protein coding gene	Chr8:68845510-68853347 (-)
AKR/J	MGP_AKRJ_G0033649	protein coding gene	Chr8:70864560-70872403 (-)
BALB/cJ	MGP_BALBcJ_G0033720	protein coding gene	Chr8:69011569-69019401 (-)
C3H/HeJ	MGP_C3HHeJ_G0033430	protein coding gene	Chr8:71449172-71457004 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034238	protein coding gene	Chr8:74506447-74514284 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031180	protein coding gene	Chr8:63481601-63489434 (-)
CAST/EiJ	MGP_CASTEiJ_G0032755	protein coding gene	Chr8:70902421-70910267 (-)
CBA/J	MGP_CBAJ_G0033408	protein coding gene	Chr8:77123420-77131252 (-)
DBA/2J	MGP_DBA2J_G0033562	protein coding gene	Chr8:68573281-68581113 (-)
FVB/NJ	MGP_FVBNJ_G0033504	protein coding gene	Chr8:67651301-67659133 (-)
LP/J	MGP_LPJ_G0033649	protein coding gene	Chr8:71741456-71749288 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033551	protein coding gene	Chr8:79702806-79710643 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034255	protein coding gene	Chr8:70934592-70942424 (-)
PWK/PhJ	MGP_PWKPhJ_G0032462	protein coding gene	Chr8:67845734-67853572 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032299	protein coding gene	Chr8:69897034-69905644 (-)
WSB/EiJ	MGP_WSBEiJ_G0032870	protein coding gene	Chr8:71283647-71291490 (-)

Human Ortholog

NR2F6, nuclear receptor subfamily 2 group F member 6

Vertebrate Orthologs

10

Human Ortholog

NR2F6, nuclear receptor subfamily 2 group F member 6
Orthology source: HomoloGene, HGNC
Synonyms

EAR2, EAR-2, ERBAL2
Links

HGNC:7977

NCBI Gene ID: 2063

neXtProt AC: NX_P10588

UniProt: P10588
Chr Location

19p13.11; chr19:17231885-17245342 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7706
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NR2F6
Protein SuperFamily

retinoic X receptor-like nuclear receptor
Gene Tree

Nr2f6

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Nr2f6
Incidental Mutations

CvDC
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit partial agenesis of the locus coeruleus, increased thermal nociception, and defective circadian behavior including a delayed entrainment to shifted light-dark cycles and reduced anticipatory locomotor activity in restricted feeding experiments.

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All GO Annotations

25
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

932
Tissues

213
cDNA Data

17
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nr2f6

ZFIN nr2f6a, nr2f6b

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Nr2f6 interacts with 61 markers (Mir7-1, Mir17, Mir20b, ...) View All

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All Sequences

60
RefSeq

10
UniProt

4
CCDS

CCDS22392.1

Ensembl

ENSMUSG00000002393 (Evidence)
NCBI Gene

13864

			Length	Strain/Species	Flank
genomic	ENSMUSG00000002393	Ensembl Gene Model \| MGI Sequence Detail	7838	C57BL/6J	± kb
transcript	ENSMUST00000002466	Ensembl \| MGI Sequence Detail	2218	Not Applicable
polypeptide	ENSMUSP00000002466	Ensembl \| MGI Sequence Detail	390	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000029648 nuclear receptor subfamily 2 group F member 6

(term hierarchy)
InterPro Domains

IPR001723 Nuclear hormone receptor

IPR000536 Nuclear hormone receptor, ligand-binding domain

IPR035500 Nuclear hormone receptor-like domain superfamily

IPR013088 Zinc finger, NHR/GATA-type

IPR001628 Zinc finger, nuclear hormone receptor-type

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All nucleic 25

cDNA 18

Primer pair 4

Other 3

Microarray probesets 4

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MGD-MRK-16308, MGI:2142737, MGI:99530

Summaries

All 59

Developmental Gene Expression 19

Gene Ontology 8

Phenotypes 13
Earliest

J:18334 Barnhart KM, et al., The sequence of a murine cDNA encoding Ear-2, a nuclear orphan receptor. Gene. 1994 May 16;142(2):313-4
Latest

J:282625 Olson WJ, et al., Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21. Cell Rep. 2019 Sep 10;28(11):2878-2891.e5

TSS for Nr2f6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr81704	Chr8:71382068-71382079 (-)	-114 bp
Tssr81703	Chr8:71381993-71382004 (-)	-39 bp
Tssr81702	Chr8:71381907-71381977 (-)	18 bp
Tssr81701	Chr8:71381693-71381714 (-)	256 bp
Tssr2603	Chr8:71381617-71381692 (-)	305 bp
Tssr81700	Chr8:71381445-71381482 (-)	496 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 04/06/2021 MGI 6.16