Nr2f6
Gene Detail

Symbol

Name
ID

Nr2f6
nuclear receptor subfamily 2, group F, member 6
MGI:1352453

Synonyms

COUP-TF3, EAR2, Erbal2

Feature Type

protein coding gene

Genetic Map

Chromosome 8
34.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:71374123-71381960 bp, - strand From VEGA annotation of GRCm38   7838 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:7706  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: retinoic X receptor-like nuclear receptor
Gene Tree: Nr2f6

Human
homologs

Human Homolog		NR2F6, nuclear receptor subfamily 2, group F, member 6
NCBI Gene ID		2063
neXtProt AC		NX_P10588
Human Synonyms		EAR2, EAR-2, ERBAL2
Human Chr (Location)		19p13.1; chr19:17231885-17245342 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(3) : Gene trapped(1) Targeted(2)
 

Mice homozygous for a knock-out allele exhibit partial agenesis of the locus coeruleus, increased thermal nociception, and defective circadian behavior including a delayed entrainment to shifted light-dark cycles and reduced anticipatory locomotor activity in restricted feeding experiments.

 

Interactions

Nr2f6 interacts with 62 markers (Mir7-1, Mir17, Mir20b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (25 annotations)

Process	detection of temperature stimulus involved in sensory perception of pain, entrainment of circadian clock by photoperiod, ...
Component	nucleus
Function	DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)

Data Summary: Results (294)    Tissues (208)    Images (53)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	283
RT-PCR	11

cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(23) cDNA(17) Primer pair(4) Other(2)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000022854 (Evidence)
Ensembl Gene Model	ENSMUSG00000002393 (Evidence)
Entrez Gene	13864 (Evidence)
DFCI	TC1722302, TC1675610, TC1621305, TC1585745, TC1580241
Consensus CDS Project	CCDS22392.1
International Mouse Knockout Project Status	Nr2f6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022854	VEGA Gene Model | MGI Sequence Detail	7838	C57BL/6J
transcript	OTTMUST00000054954	VEGA | MGI Sequence Detail	2218	Not Applicable
polypeptide	OTTMUSP00000026253	VEGA | MGI Sequence Detail	390	Not Applicable

All sequences(58) RefSeq(6) UniProt(7)

Polymorphisms

SNPs within 2kb(78 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR003068	Transcription factor COUP
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000029648	nuclear receptor subfamily 2 group F member 6

References

(Earliest) J:18334 Barnhart KM, et al., The sequence of a murine cDNA encoding Ear-2, a nuclear orphan receptor. Gene. 1994 May 16;142(2):313-4
(Latest) J:212542 Kummer MP, et al., Ear2 deletion causes early memory and learning deficits in APP/PS1 mice. J Neurosci. 2014 Jun 25;34(26):8845-54
All references(49)

Other
accession IDs

MGD-MRK-16308, MGI:2142737, MGI:99530