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Nr2f6 Gene Detail
Summary
  • Symbol
    Nr2f6
  • Name
    nuclear receptor subfamily 2, group F, member 6
  • Synonyms
    COUP-TF3, EAR2, Erbal2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352453
    NCBI Gene: 13864
  • Gene Overview
    MyGene.info: NR2F6
Location & Maps
more
  • Sequence Map
    Chr8:71374123-71381960 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7838 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.43 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NR2F6, nuclear receptor subfamily 2 group F member 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NR2F6, nuclear receptor subfamily 2 group F member 6
    Orthology source: HomoloGene
  • Synonyms
    EAR2, EAR-2, ERBAL2
  • Links
    NCBI Gene ID: 2063
    neXtProt AC: NX_P10588

  • Chr Location
    19p13.1; chr19:17231885-17245342 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Nr2f6
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit partial agenesis of the locus coeruleus, increased thermal nociception, and defective circadian behavior including a delayed entrainment to shifted light-dark cycles and reduced anticipatory locomotor activity in restricted feeding experiments.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022854 VEGA Gene Model | MGI Sequence Detail 7838 C57BL/6J ±  kb
transcript OTTMUST00000054954 VEGA | MGI Sequence Detail 2218 Not Applicable  
polypeptide OTTMUSP00000026253 VEGA | MGI Sequence Detail 390 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    76 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000029648 nuclear receptor subfamily 2 group F member 6
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR003068 Transcription factor COUP
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 23
    cDNA 17
    Primer pair 4
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-16308, MGI:2142737, MGI:99530
References
more
  • Summaries
    All 48
    Developmental Gene Expression 18
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:18334 Barnhart KM, et al., The sequence of a murine cDNA encoding Ear-2, a nuclear orphan receptor. Gene. 1994 May 16;142(2):313-4
  • Latest
    J:215426 Ichim CV, et al., The orphan nuclear receptor Ear-2 (Nr2f6) is a novel negative regulator of T cell development. Exp Hematol. 2014 Jan;42(1):46-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory