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Nr2f6
Gene Detail
Symbol

Name
ID
Nr2f6
nuclear receptor subfamily 2, group F, member 6
MGI:1352453
Synonyms
COUP-TF3, EAR2, Erbal2
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:71374123-71381960 bp, - strand
From VEGA annotation of GRCm38

  7838 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7706  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: retinoic X receptor-like nuclear receptor
Gene Tree: Nr2f6

Human
homologs
Human Homolog NR2F6, nuclear receptor subfamily 2, group F, member 6
NCBI Gene ID 2063
neXtProt AC  NX_P10588
Human Synonyms  EAR2, EAR-2, ERBAL2
Human Chr (Location)  19p13.1; chr19:17231885-17245342 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
 
Mice homozygous for a knock-out allele exhibit partial agenesis of the locus coeruleus, increased thermal nociception, and defective circadian behavior including a delayed entrainment to shifted light-dark cycles and reduced anticipatory locomotor activity in restricted feeding experiments.
 
Interactions
Nr2f6 interacts with 62 markers (Mir7-1, Mir17, Mir20b, ...)
Expression
Literature Summary: (18 records)
Data Summary: Results (294)    Tissues (208)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 283
RT-PCR 11
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(17) Primer pair(4) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022854 (Evidence)
Ensembl Gene ModelENSMUSG00000002393 (Evidence)
Entrez Gene13864 (Evidence)
DFCITC1675610, TC1621305, TC1722302, TC1585745, TC1580241
Consensus CDS ProjectCCDS22392.1
International Mouse Knockout Project StatusNr2f6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022854 VEGA Gene Model | MGI Sequence Detail 7838 C57BL/6J ±  kb
transcript OTTMUST00000054954 VEGA | MGI Sequence Detail 2218 Not Applicable 
polypeptide OTTMUSP00000026253 VEGA | MGI Sequence Detail 390 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(6) UniProt(7)
Polymorphisms
SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR003068 Transcription factor COUP
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000029648 nuclear receptor subfamily 2 group F member 6
References
(Earliest) J:18334 Barnhart KM, et al., The sequence of a murine cDNA encoding Ear-2, a nuclear orphan receptor. Gene. 1994 May 16;142(2):313-4
(Latest) J:212542 Kummer MP, et al., Ear2 deletion causes early memory and learning deficits in APP/PS1 mice. J Neurosci. 2014 Jun 25;34(26):8845-54
All references(49)
Other
accession IDs
MGD-MRK-16308, MGI:2142737, MGI:99530

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory