About   Help   FAQ
Nr2f6 Gene Detail
Summary
  • Symbol
    Nr2f6
  • Name
    nuclear receptor subfamily 2, group F, member 6
  • Synonyms
    COUP-TF3, EAR2, Erbal2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352453
    NCBI Gene: 13864
  • Gene Overview
    MyGene.info: NR2F6
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71374118-71381952 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352453
 protein coding gene Chr8:71374118-71381960 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033741
 protein coding gene Chr8:71763805-71771637 (-)
A/J MGP_AJ_G0033724
 protein coding gene Chr8:68845510-68853347 (-)
AKR/J MGP_AKRJ_G0033649
 protein coding gene Chr8:70864560-70872403 (-)
BALB/cJ MGP_BALBcJ_G0033720
 protein coding gene Chr8:69011569-69019401 (-)
C3H/HeJ MGP_C3HHeJ_G0033430
 protein coding gene Chr8:71449172-71457004 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034238
 protein coding gene Chr8:74506447-74514284 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031180
 protein coding gene Chr8:63481601-63489434 (-)
CAST/EiJ MGP_CASTEiJ_G0032755
 protein coding gene Chr8:70902421-70910267 (-)
CBA/J MGP_CBAJ_G0033408
 protein coding gene Chr8:77123420-77131252 (-)
DBA/2J MGP_DBA2J_G0033562
 protein coding gene Chr8:68573281-68581113 (-)
FVB/NJ MGP_FVBNJ_G0033504
 protein coding gene Chr8:67651301-67659133 (-)
LP/J MGP_LPJ_G0033649
 protein coding gene Chr8:71741456-71749288 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033551
 protein coding gene Chr8:79702806-79710643 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034255
 protein coding gene Chr8:70934592-70942424 (-)
PWK/PhJ MGP_PWKPhJ_G0032462
 protein coding gene Chr8:67845734-67853572 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032299
 protein coding gene Chr8:69897034-69905644 (-)
WSB/EiJ MGP_WSBEiJ_G0032870
 protein coding gene Chr8:71283647-71291490 (-)



Homology
more
  • Human Ortholog
    NR2F6, nuclear receptor subfamily 2 group F member 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NR2F6, nuclear receptor subfamily 2 group F member 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EAR2, EAR-2, ERBAL2
  • Links
    NCBI Gene ID: 2063
    neXtProt AC: NX_P10588
    UniProt: P10588

  • Chr Location
    19p13.11; chr19:17231885-17245342 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial agenesis of the locus coeruleus, increased thermal nociception, and defective circadian behavior including a delayed entrainment to shifted light-dark cycles and reduced anticipatory locomotor activity in restricted feeding experiments.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    301
  • Tissues
    213
  • cDNA Data
    17
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13864 NCBI Gene Model | MGI Sequence Detail 7835 C57BL/6J ±  kb
    transcript NM_010150 RefSeq | MGI Sequence Detail 2218 C57BL/6  
    polypeptide P43136 UniProt | EBI | MGI Sequence Detail 390 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000029648 nuclear receptor subfamily 2 group F member 6
      (term hierarchy)
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 18
      Primer pair 4
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16308, MGI:2142737, MGI:99530
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 19
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:18334 Barnhart KM, et al., The sequence of a murine cDNA encoding Ear-2, a nuclear orphan receptor. Gene. 1994 May 16;142(2):313-4
    • Latest
      J:265472 Klepsch V, et al., Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade. Nat Commun. 2018 Apr 18;9(1):1538
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    10/15/2019
    MGI 6.14     		The Jackson Laboratory