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Cxcl10
Gene Detail
 Symbol
Name
ID
Cxcl10
chemokine (C-X-C motif) ligand 10
MGI:1352450
Synonyms C7, CRG-2, gIP-10, Ifi10, INP10, IP10, IP-10, mob-1, Scyb10
Feature Type protein coding gene
Genetic Map
Chromosome 5
46.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:92346638-92348889 bp, - strand
From VEGA annotation of GRCm38

  2252 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1203  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: CXC chemokine
Gene Tree: Cxcl10

Human
homologs
Human Homolog CXCL10, chemokine (C-X-C motif) ligand 10
NCBI Gene ID 3627
neXtProt AC  NX_P02778
Human Synonyms  C7, crg-2, gIP-10, IFI10, INP10, IP-10, mob-1, SCYB10
Human Chr (Location)  4q21; chr4:76021116-76023536 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix )
 
Mice homozygouse for disruptions of this gene have immune system abnormalities leading to increased susceptibility toautoimmune disease and to some viral infections.
 
Interactions
Cxcl10 interacts with 126 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cellular response to lipopolysaccharide, chemokine-mediated signaling pathway, ...
Component cell, external side of plasma membrane, ...
Function chemokine activity, CXCR3 chemokine receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (101)    Tissues (95)    Images (8)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 98
Northern blot 3
cDNA source data(49)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) Genomic(1) cDNA(52) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028740 (Evidence)
Ensembl Gene ModelENSMUSG00000034855 (Evidence)
Entrez Gene15945 (Evidence)
UniGene877
DFCITC1575713, TC1601156, TC1618005, TC1660329
DoTSDT.101162057, DT.101290253, DT.94022515, DT.99865667
NIA Mouse Gene IndexU026409
PDB2R3Z
Consensus CDS ProjectCCDS39153.1
International Mouse Knockout Project StatusCxcl10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028740 VEGA Gene Model | MGI Sequence Detail 2252 C57BL/6J ±  kb
transcript OTTMUST00000071189 VEGA | MGI Sequence Detail 1094 Not Applicable 
polypeptide OTTMUSP00000036424 VEGA | MGI Sequence Detail 98 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(2) UniProt(7)
Polymorphisms SNPs within 2kb(88 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001811 Chemokine interleukin-8-like domain
InterPro IPR001089 CXC chemokine
InterPro IPR027220 CXC chemokine 10
InterPro IPR018048 CXC chemokine, conserved site
Protein Ontology PR:000006064 C-X-C motif chemokine 10
References (Earliest) J:10527 Ohmori Y, et al., A macrophage LPS-inducible early gene encodes the murine homologue of IP-10. Biochem Biophys Res Commun. 1990 May 16;168(3):1261-7
(Latest) J:208545 Coppieters KT, et al., Functional redundancy of CXCR3/CXCL10 signaling in the recruitment of diabetogenic cytotoxic T lymphocytes to pancreatic islets in a virally induced autoimmune diabetes model. Diabetes. 2013 Jul;62(7):2492-9
All references(99)
Other
accession IDs
MGD-MRK-11217, MGI:96424

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory