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Cxcl10 Gene Detail
Summary
  • Symbol
    Cxcl10
  • Name
    chemokine (C-X-C motif) ligand 10
  • Synonyms
    C7, CRG-2, gIP-10, Ifi10, INP10, IP10, IP-10, mob-1, Scyb10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352450
    NCBI Gene: 15945
Location & Maps
more
  • Sequence Map
    Chr5:92346638-92348889 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2252 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CXCL10, chemokine (C-X-C motif) ligand 10
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CXCL10, chemokine (C-X-C motif) ligand 10
    Orthology source: HomoloGene
  • Synonyms
    C7, crg-2, gIP-10, IFI10, INP10, IP-10, mob-1, SCYB10
  • Links
    NCBI Gene ID: 3627
    neXtProt AC: NX_P02778

  • Chr Location
    4q21; chr4:76021116-76023536 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    3 involving Cxcl10
  • Incidental Mutations
Mice homozygouse for disruptions of this gene have immune system abnormalities leading to increased susceptibility toautoimmune disease and to some viral infections.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028740 VEGA Gene Model | MGI Sequence Detail 2252 C57BL/6J ±  kb
transcript OTTMUST00000071189 VEGA | MGI Sequence Detail 1094 Not Applicable  
polypeptide OTTMUSP00000036424 VEGA | MGI Sequence Detail 98 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    88 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
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  • All nucleic 55
    Genomic 1
    cDNA 52
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11217, MGI:96424
References
more
  • Summaries
    All 102
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 45
  • Earliest
    J:10527 Ohmori Y, et al., A macrophage LPS-inducible early gene encodes the murine homologue of IP-10. Biochem Biophys Res Commun. 1990 May 16;168(3):1261-7
  • Latest
    J:227017 Ryu JK, et al., Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Nat Commun. 2015;6:8164

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory