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Cxcl10 Gene Detail
Summary
  • Symbol
    Cxcl10
  • Name
    chemokine (C-X-C motif) ligand 10
  • Synonyms
    C7, CRG-2, gIP-10, Ifi10, INP10, IP10, IP-10, mob-1, Scyb10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352450
    NCBI Gene: 15945
  • Gene Overview
    MyGene.info: CXCL10
  • Alliance
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:92346638-92348889 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 46.57 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352450
protein coding gene Chr5:92346638-92348889 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029750
protein coding gene Chr5:93530797-93533077 (-)
A/J MGP_AJ_G0029716
protein coding gene Chr5:89813797-89816048 (-)
AKR/J MGP_AKRJ_G0029662
protein coding gene Chr5:92754345-92756591 (-)
BALB/cJ MGP_BALBcJ_G0029726
protein coding gene Chr5:90698217-90700463 (-)
C3H/HeJ MGP_C3HHeJ_G0029449
protein coding gene Chr5:93157324-93159570 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030180
protein coding gene Chr5:97242477-97245742 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027416
protein coding gene Chr5:85464649-85466924 (-)
CAST/EiJ MGP_CASTEiJ_G0028859
protein coding gene Chr5:92536995-92539256 (-)
CBA/J MGP_CBAJ_G0029419
protein coding gene Chr5:100616202-100618448 (-)
DBA/2J MGP_DBA2J_G0029563
protein coding gene Chr5:89862074-89864320 (-)
FVB/NJ MGP_FVBNJ_G0029522
protein coding gene Chr5:88706997-88709243 (-)
LP/J MGP_LPJ_G0029651
protein coding gene Chr5:93895589-93899232 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029551
protein coding gene Chr5:105530034-105533430 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030214
protein coding gene Chr5:92280802-92283053 (-)
PWK/PhJ MGP_PWKPhJ_G0028578
protein coding gene Chr5:88927014-88929302 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028413
protein coding gene Chr5:91644919-91647173 (-)
WSB/EiJ MGP_WSBEiJ_G0028938
protein coding gene Chr5:92749768-92752014 (-)



Homology
more
  • Human Ortholog
    CXCL10, C-X-C motif chemokine ligand 10
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CXCL10, C-X-C motif chemokine ligand 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C7, crg-2, gIP-10, IFI10, INP10, IP-10, mob-1, SCYB10
  • Links
    NCBI Gene ID: 3627
    neXtProt AC: NX_P02778
    UniProt: P02778

  • Chr Location
    4q21.1; chr4:76021116-76023536 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygouse for disruptions of this gene have immune system abnormalities leading to increased susceptibility toautoimmune disease and to some viral infections.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15945 NCBI Gene Model | MGI Sequence Detail 2252 C57BL/6J ±  kb
    transcript NM_021274 RefSeq | MGI Sequence Detail 1120 C57BL/6  
    polypeptide P17515 UniProt | EBI | MGI Sequence Detail 98 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 1
      cDNA 53
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11217, MGI:96424
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 8
      Gene Ontology 13
      Phenotypes 50
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:253337 Alanio C, et al., CXCR3/CXCL10 Axis Shapes Tissue Distribution of Memory Phenotype CD8(+) T Cells in Nonimmunized Mice. J Immunol. 2018 Jan 1;200(1):139-146

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory