About   Help   FAQ
Cxcl9 Gene Detail
Summary
  • Symbol
    Cxcl9
  • Name
    chemokine (C-X-C motif) ligand 9
  • Synonyms
    CMK, crg-10, Mig, Scyb9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352449
    NCBI Gene: 17329
  • Gene Overview
    MyGene.info: CXCL9
Location & Maps
more
  • Sequence Map
    Chr5:92321347-92328079 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6733 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 46.51 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CXCL9, C-X-C motif chemokine ligand 9
  • Vertebrate Orthologs
    2
  • Human Ortholog
    CXCL9, C-X-C motif chemokine ligand 9
    Orthology source: HGNC
  • Synonyms
    CMK, crg-10, Humig, MIG, SCYB9
  • Links
    NCBI Gene ID: 4283
    neXtProt AC: NX_Q07325

  • Chr Location
    4q21.1; chr4:76001342-76007523 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Cxcl9
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele show a significant reduction in CD4+ T cell infiltration into the cornea in response to ocular HSV-1 infection, and produce lower titers of antibodies in response to primary infection with the intracellular bacterium Francisella tularensis live vaccine strain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055603 VEGA Gene Model | MGI Sequence Detail 6733 C57BL/6J ±  kb
transcript OTTMUST00000137614 VEGA | MGI Sequence Detail 2889 Not Applicable  
polypeptide OTTMUSP00000072452 VEGA | MGI Sequence Detail 126 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    109 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 81
    Genomic 1
    cDNA 79
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33048, MGI:105379, MGI:2141267
References
more
  • Summaries
    All 65
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:31894 Farber JM, A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. Proc Natl Acad Sci U S A. 1990 Jul;87(14):5238-42
  • Latest
    J:233073 1857225de Valle E, et al., NFkappaB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells. J Exp Med. 2016 Apr 4;213(4):621-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory