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Cxcl9 Gene Detail
Summary
  • Symbol
    Cxcl9
  • Name
    C-X-C motif chemokine ligand 9
  • Synonyms
    CMK, crg-10, Mig, Scyb9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352449
    NCBI Gene: 17329
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:92469206-92475938 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 46.51 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352449
 protein coding gene Chr5:92469190-92475938 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029748
 protein coding gene Chr5:93501538-93509633 (-)
A/J MGP_AJ_G0029714
 protein coding gene Chr5:89787722-89794447 (-)
AKR/J MGP_AKRJ_G0029660
 protein coding gene Chr5:92727263-92733940 (-)
BALB/cJ MGP_BALBcJ_G0029724
 protein coding gene Chr5:90672575-90679252 (-)
C3H/HeJ MGP_C3HHeJ_G0029447
 protein coding gene Chr5:93131302-93137979 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030178
 protein coding gene Chr5:97213374-97220106 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027414
 protein coding gene Chr5:85438707-85445306 (-)
CAST/EiJ MGP_CASTEiJ_G0028857
 protein coding gene Chr5:92506726-92515558 (-)
CBA/J MGP_CBAJ_G0029417
 protein coding gene Chr5:100587931-100594608 (-)
DBA/2J MGP_DBA2J_G0029561
 protein coding gene Chr5:89835527-89842768 (-)
FVB/NJ MGP_FVBNJ_G0029520
 protein coding gene Chr5:88680703-88687380 (-)
LP/J MGP_LPJ_G0029649
 protein coding gene Chr5:93870395-93877053 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029549
 protein coding gene Chr5:105494358-105510205 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030212
 protein coding gene Chr5:92254388-92261121 (-)
PWK/PhJ MGP_PWKPhJ_G0028576
 protein coding gene Chr5:88900525-88907211 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028411
 protein coding gene Chr5:91618426-91625077 (-)
WSB/EiJ MGP_WSBEiJ_G0028936
 protein coding gene Chr5:92721671-92728348 (-)



Homology
more
  • Human Ortholog
    CXCL9, C-X-C motif chemokine ligand 9
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CXCL9, C-X-C motif chemokine ligand 9
  • Synonyms
    CMK, crg-10, Humig, MIG, SCYB9
  • Links
    NCBI Gene ID: 4283
    neXtProt AC: NX_Q07325
    UniProt: Q07325

  • Chr Location
    4q21.1; chr4:76001275-76007509 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show a significant reduction in CD4+ T cell infiltration into the cornea in response to ocular HSV-1 infection, and produce lower titers of antibodies in response to primary infection with the intracellular bacterium Francisella tularensis live vaccine strain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    49
  • cDNA Data
    80
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029417 Ensembl Gene Model | MGI Sequence Detail 6733 C57BL/6J ±  kb
    transcript ENSMUST00000113093 Ensembl | MGI Sequence Detail 2889 Not Applicable  
    polypeptide ENSMUSP00000108716 Ensembl | MGI Sequence Detail 126 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 1
      cDNA 80
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33048, MGI:105379, MGI:2141267
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 9
      Gene Ontology 7
      Phenotypes 37
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:339169 Diamond T, et al., CXCL9 inhibition does not ameliorate disease in murine models of both primary and secondary hemophagocytic lymphohistiocytosis. Sci Rep. 2023 Jul 29;13(1):12298
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory