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Pkd2l1
Gene Detail
Symbol

Name
ID
Pkd2l1
polycystic kidney disease 2-like 1
MGI:1352448
Synonyms
PCL, PKD2L, Pkdl, polycystin-L, TRPP3
Feature Type
protein coding gene
Genetic Map
Chromosome 19
36.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:44147637-44192442 bp, - strand
From VEGA annotation of GRCm38

  44806 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22946  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transient receptor potential cation channel, subfamily P
Gene Tree: Pkd2l1

Human
homologs
Human Homolog PKD2L1, polycystic kidney disease 2-like 1
NCBI Gene ID 9033
neXtProt AC  NX_Q9P0L9
Human Synonyms  PCL, PKD2L, PKDL, TRPP3
Human Chr (Location)  10q24; chr10:100288146-100330486 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased chorda tympani nerve response to sour tastants.
 
Interactions
Pkd2l1 interacts with 143 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (14)    Tissues (7)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
RT-PCR 7
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000033257 (Evidence)
Ensembl Gene ModelENSMUSG00000037578 (Evidence)
Entrez Gene329064 (Evidence)
UniGene308481
DFCITC1587225
DoTSDT.101716488, DT.94273751
NIA Mouse Gene IndexU039073
Consensus CDS ProjectCCDS29846.1
International Mouse Knockout Project StatusPkd2l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033257 VEGA Gene Model | MGI Sequence Detail 44806 C57BL/6J ±  kb
transcript OTTMUST00000083379 VEGA | MGI Sequence Detail 3321 Not Applicable 
polypeptide OTTMUSP00000044798 VEGA | MGI Sequence Detail 760 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(9) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(448 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR003915 Polycystic kidney disease type 2 protein
InterPro IPR013122 Polycystin cation channel, PKD1/PKD2
Protein Ontology PR:000012774 polycystic kidney disease 2-like 1 protein
References
(Earliest) J:50327 Nomura H, et al., Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects. J Biol Chem. 1998 Oct 2;273(40):25967-73
(Latest) J:207901 Delling M, et al., Primary cilia are specialized calcium signalling organelles. Nature. 2013 Dec 12;504(7479):311-4
All references(37)
Other
accession IDs
MGI:1330816, MGI:3040679

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory