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Trpm2 Gene Detail
Summary
  • Symbol
    Trpm2
  • Name
    transient receptor potential cation channel, subfamily M, member 2
  • Synonyms
    9830168K16Rik, LTRPC2, TRPC7, Trrp7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351901
    NCBI Gene: 28240
  • Gene Overview
    MyGene.info: TRPM2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:77907722-77969911 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    221 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351901
protein coding gene Chr10:77907722-77970563 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017411
protein coding gene Chr10:78309169-78371850 (-)
A/J MGP_AJ_G0017389
protein coding gene Chr10:75608187-75664709 (-)
AKR/J MGP_AKRJ_G0017352
protein coding gene Chr10:77622002-77680141 (-)
BALB/cJ MGP_BALBcJ_G0017351
protein coding gene Chr10:75774892-75832263 (-)
C3H/HeJ MGP_C3HHeJ_G0017174
protein coding gene Chr10:77710124-77768222 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017807
protein coding gene Chr10:81093594-81154552 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015498
protein coding gene Chr10:71953886-72015286 (-)
CAST/EiJ MGP_CASTEiJ_G0016744
protein coding gene Chr10:78033712-78091480 (-)
CBA/J MGP_CBAJ_G0017146
protein coding gene Chr10:84163662-84228302 (-)
DBA/2J MGP_DBA2J_G0017254
protein coding gene Chr10:74842049-74897759 (-)
FVB/NJ MGP_FVBNJ_G0017246
protein coding gene Chr10:74017006-74081398 (-)
LP/J MGP_LPJ_G0017325
protein coding gene Chr10:78755342-78822254 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017273
protein coding gene Chr10:86169830-86231933 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017849
protein coding gene Chr10:77657687-77717010 (-)
PWK/PhJ MGP_PWKPhJ_G0016526
protein coding gene Chr10:74726621-74782097 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016311
protein coding gene Chr10:76876064-76942100 (-)
WSB/EiJ MGP_WSBEiJ_G0016804
protein coding gene Chr10:77639846-77701478 (-)



Homology
more
  • Human Ortholog
    TRPM2, transient receptor potential cation channel subfamily M member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRPM2, transient receptor potential cation channel subfamily M member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EREG1, KNP3, LTrpC-2, LTRPC2, NUDT9H, NUDT9L1, TRPC7
  • Links
    NCBI Gene ID: 7226
    neXtProt AC: NX_O94759
    UniProt: O94759

  • Chr Location
    21q22.3; chr21:44350112-44443081 (+)  GRCh38.p7

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 5 alleles in 6 genetic backgrounds
    1 images
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display impaired reactive oxygen species (ROS)-induced chemokine production in monocytes, and reduced neutrophil infiltration and ulceration in a dextran sulfate sodium-induced colitis inflammation model.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 28240 NCBI Gene Model | MGI Sequence Detail 62190 C57BL/6J ±  kb
    transcript NM_138301 RefSeq | MGI Sequence Detail 7292 C57BL/6  
    polypeptide Q91YD4 UniProt | EBI | MGI Sequence Detail 1506 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR005821 Ion transport domain
      IPR000086 NUDIX hydrolase domain
      IPR015797 NUDIX hydrolase-like domain superfamily
      IPR029594 Transient receptor potential cation channel subfamily M member 2
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 10
      cDNA 17
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143924, MGI:2444747
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 10
      Diseases 2
      Gene Ontology 7
      Phenotypes 66
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:266090 Xia W, et al., Cold-induced protein RBM3 orchestrates neurogenesis via modulating Yap mRNA stability in cold stress. J Cell Biol. 2018 Oct 1;217(10):3464-3479

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory