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Trpm2 Gene Detail
Summary
  • Symbol
    Trpm2
  • Name
    transient receptor potential cation channel, subfamily M, member 2
  • Synonyms
    9830168K16Rik, LTRPC2, TRPC7, Trrp7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351901
    NCBI Gene: 28240
  • Gene Overview
    MyGene.info: TRPM2
Location & Maps
more
  • Sequence Map
    Chr10:77907722-77970563 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      62842 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TRPM2, transient receptor potential cation channel subfamily M member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRPM2, transient receptor potential cation channel subfamily M member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EREG1, KNP3, LTrpC-2, LTRPC2, NUDT9H, NUDT9L1, TRPC7
  • Links
    NCBI Gene ID: 7226
    neXtProt AC: NX_O94759

  • Chr Location
    21q22.3; chr21:44350126-44443081 (+)  GRCh38.p2

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 4 alleles in 5 genetic backgrounds
    1 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    11
  • Genomic Mutations
    4 involving Trpm2
  • Incidental Mutations
Mice homozygous for a knock-out allele display impaired reactive oxygen species (ROS)-induced chemokine production in monocytes, and reduced neutrophil infiltration and ulceration in a dextran sulfate sodium-induced colitis inflammation model.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020526 VEGA Gene Model | MGI Sequence Detail 62842 C57BL/6J ±  kb
transcript OTTMUST00000048670 VEGA | MGI Sequence Detail 7274 Not Applicable  
polypeptide OTTMUSP00000022373 VEGA | MGI Sequence Detail 1506 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    221 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016698 transient receptor potential cation channel subfamily M member 2
  • EC
  • InterPro Domains
    IPR005821 Ion transport domain
    IPR000086 NUDIX hydrolase domain
    IPR015797 NUDIX hydrolase domain-like
    IPR029594 Transient receptor potential cation channel subfamily M member 2
Molecular
Reagents
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  • All nucleic 29
    Genomic 10
    cDNA 15
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
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MGI:2143924, MGI:2444747
References
more
  • Summaries
    All 74
    Developmental Gene Expression 8
    Diseases 2
    Gene Ontology 5
    Phenotypes 47
  • Earliest
    J:59327 Wiltshire T, et al., Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21. Genome Res. 1999 Dec;9(12):1214-22
  • Latest
    J:229553 Shimizu K, et al., Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels. Exp Neurol. 2016 Jan;275 Pt 1:78-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory