Trpm2
Gene Detail

Symbol Name ID

Trpm2 transient receptor potential cation channel, subfamily M, member 2 MGI:1351901

Synonyms

9830168K16Rik, LTRPC2, TRPC7, Trrp7

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:77907722-77970563 bp, - strand From VEGA annotation of GRCm38   62842 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20709  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: transient receptor potential cation channel TRPM2
Gene Tree: Trpm2

Human homologs

Human Homolog		TRPM2, transient receptor potential cation channel, subfamily M, member 2
NCBI Gene ID		7226
neXtProt AC		NX_O94759
Human Synonyms		EREG1, KNP3, LTRPC2, NUDT9H, NUDT9L1, TRPC7
Human Chr (Location)		21q22.3; chr21:45773484-45862964 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Mice homozygous for a knock-out allele display impaired reactive oxygen species (ROS)-induced chemokine production in monocytes, and reduced neutrophil infiltration and ulceration in a dextran sulfate sodium-induced colitis inflammation model.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	integral to membrane, membrane, ...
Function	ADP-ribose diphosphatase activity, calcium channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (188)    Tissues (143)    Images (15)
Theiler Stages: 13, 15, 17, 20, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	142
RT-PCR	46

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(10) cDNA(15) Primer pair(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000020526 (Evidence)
Ensembl Gene Model	ENSMUSG00000009292 (Evidence)
Entrez Gene	28240 (Evidence)
UniGene	276762
DFCI	TC1583705, TC1615939, TC1617858, TC1623060, TC1693762
DoTS	DT.101366575, DT.110614907, DT.110614917, DT.40154367, DT.522478, DT.55129416, DT.91358579, DT.94251906
NIA Mouse Gene Index	U031963
EC	3.6.1.13
Consensus CDS Project	CCDS48611.1
International Mouse Knockout Project Status	Trpm2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020526	VEGA Gene Model | MGI Sequence Detail	62842	C57BL/6J
transcript	OTTMUST00000048670	VEGA | MGI Sequence Detail	7274	Not Applicable
polypeptide	OTTMUSP00000022373	VEGA | MGI Sequence Detail	1506	Not Applicable

All sequences(58) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(220 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005821	Ion transport domain
InterPro	IPR000086	NUDIX hydrolase domain
InterPro	IPR015797	NUDIX hydrolase domain-like
Protein Ontology	PR:000016698	transient receptor potential cation channel subfamily M member 2

References

(Earliest) J:59327 Wiltshire T, et al., Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21. Genome Res. 1999 Dec;9(12):1214-22
(Latest) J:192207 Melzer N, et al., TRPM2 cation channels modulate T cell effector functions and contribute to autoimmune CNS inflammation. PLoS One. 2012;7(10):e47617
All references(57)

Other accession IDs

MGI:2143924, MGI:2444747