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Slco1b2
Gene Detail
Symbol

Name
ID
Slco1b2
solute carrier organic anion transporter family, member 1b2
MGI:1351899
Synonyms
7330442B20Rik, mlst-1, Oatp1b2, Slc21a10, Slc21a6
Feature Type
protein coding gene
Genetic Map
Chromosome 6
72.57 cM, cytoband G1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:141629518-141686646 bp, + strand
From VEGA annotation of GRCm38

  57129 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75119  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SLCO1B3
Gene Tree: Slco1b2

Human
homologs
SLCO1B3, solute carrier organic anion transporter family, member 1B3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 28234
neXtProt AC: NX_Q9NPD5

Human Synonyms: HBLRR, LST-2, LST3, LST-3TM13, OATP1B3, OATP8, OATP-8, SLC21A8

Human Chr (Location): 12p12; chr12:20810704-20916911 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLCO1B3

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Slco1b2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null mutation display slight abnormalities in blood chemistry and are resistant to injury induced by some classes of hepatotoxins.
 
Interactions
Slco1b2 interacts with 175 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (22)    Tissues (22)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 22
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(24) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000025596 (Evidence)
Ensembl Gene Model ENSMUSG00000030236 (Evidence)
Entrez Gene 28253 (Evidence)
UniGene 272223
DFCI TC1595512, TC1584326
DoTS DT.532753, DT.91398921, DT.101360055, DT.97352602, DT.97352603
NIA Mouse Gene Index U007536
Consensus CDS Project CCDS20678.1, CCDS20679.1
International Mouse Phenotyping Consortium Status Slco1b2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025596 VEGA Gene Model | MGI Sequence Detail 57129 C57BL/6J ±  kb
transcript OTTMUST00000062963 VEGA | MGI Sequence Detail 3307 Not Applicable 
polypeptide OTTMUSP00000031099 VEGA | MGI Sequence Detail 689 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(5) UniProt(1)
Polymorphisms
SNPs within 2kb(598 from dbSNP Build 137)    SNPs within 2kb including multiple locations(600)
Protein-related
information
ResourceIDDescription
InterPro IPR002350 Kazal domain
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR004156 Organic anion transporter polypeptide OATP
Protein Ontology PR:000015224 solute carrier organic anion transporter family member 1B3
References
(Earliest) J:62737 Ogura K, et al., Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1). Biochem Biophys Res Commun. 2000 Jun 7;272(2):563-70
(Latest) J:212555 Nieuweboer AJ, et al., Influence of drug formulation on OATP1B-mediated transport of paclitaxel. Cancer Res. 2014 Jun 1;74(11):3137-45
All references(39)
Other
accession IDs
MGI:1351894, MGI:1925925

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory