Slco1b2
Gene Detail

Symbol Name ID

Slco1b2 solute carrier organic anion transporter family, member 1b2 MGI:1351899

Synonyms

7330442B20Rik, mlst-1, Oatp1b2, Slc21a10, Slc21a6

Feature Type

protein coding gene

Genetic Map

Chromosome 6

72.57 cM, cytoband G1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:141629518-141686646 bp, + strand From VEGA annotation of GRCm38   57129 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:75119  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Slco1b2

Human homologs

Human Homolog		SLCO1B3, solute carrier organic anion transporter family, member 1B3
NCBI Gene ID		28234
neXtProt AC		NX_Q9NPD5
Human Synonyms		HBLRR, LST-2, LST3, LST-3TM13, OATP1B3, OATP8, OATP-8, SLC21A8
Human Chr (Location)		12p12; chr12:20963638-21069845 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLCO1B3

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a null mutation display slight abnormalities in blood chemistry and are resistant to injury induced by some classes of hepatotoxins.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	bile acid and bile salt transport, drug transmembrane transport, ...
Component	basolateral plasma membrane, cytoplasm, ...
Function	bile acid transmembrane transporter activity, drug transmembrane transporter activity, ...

External Resources: FuncBase

Expression

cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) cDNA(24) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000025596 (Evidence)
Ensembl Gene Model	ENSMUSG00000030236 (Evidence)
Entrez Gene	28253 (Evidence)
UniGene	272223
DFCI	TC1584326, TC1595512
DoTS	DT.101360055, DT.532753, DT.91398921, DT.97352602, DT.97352603
NIA Mouse Gene Index	U007536
Consensus CDS Project	CCDS20678.1, CCDS20679.1
International Mouse Knockout Project Status	Slco1b2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025596	VEGA Gene Model | MGI Sequence Detail	57129	C57BL/6J
transcript	OTTMUST00000062963	VEGA | MGI Sequence Detail	3307	Not Applicable
polypeptide	OTTMUSP00000031099	VEGA | MGI Sequence Detail	689	Not Applicable

All sequences(34) RefSeq(3) UniProt(1)

Polymorphisms

SNPs(205 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011497	Kazal-type serine protease inhibitor domain
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
InterPro	IPR004156	Organic anion transporter polypeptide OATP
InterPro	IPR002350	Proteinase inhibitor I1, Kazal
Protein Ontology	PR:000015224	solute carrier organic anion transporter family member 1B3

References

(Earliest) J:62737 Ogura K, et al., Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1). Biochem Biophys Res Commun. 2000 Jun 7;272(2):563-70
(Latest) J:184377 van de Steeg E, et al., Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J Clin Invest. 2012 Feb 1;122(2):519-28
All references(37)

Other accession IDs

MGI:1351894, MGI:1925925