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Slco1b2 Gene Detail
Summary
  • Symbol
    Slco1b2
  • Name
    solute carrier organic anion transporter family, member 1b2
  • Synonyms
    7330442B20Rik, mlst-1, Oatp1b2, Slc21a10, Slc21a6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351899
    NCBI Gene: 28253
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:141629518-141686646 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      57129 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 72.57 cM, cytoband G1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SLCO1B1, solute carrier organic anion transporter family member 1B1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SLCO1B1, solute carrier organic anion transporter family member 1B1
    Orthology source: HGNC
  • Synonyms
    HBLRR, LST1, LST-1, OATP1B1, OATP2, OATPC, OATP-C, SLC21A6
  • Links
    NCBI Gene ID: 10599
    neXtProt AC: NX_Q9Y6L6
    UniProt: Q9Y6L6

  • Chr Location
    12p12.1; chr12:21131194-21239796 (+)  GRCh38.p7

  • Human Ortholog
    SLCO1B3, solute carrier organic anion transporter family member 1B3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HBLRR, LST-2, LST3, LST-3TM13, OATP1B3, OATP8, OATP-8, SLC21A8
  • Links
    NCBI Gene ID: 28234
    neXtProt AC: NX_Q9NPD5
    UniProt: Q9NPD5

  • Chr Location
    12p12.2; chr12:20810704-20916911 (+)  GRCh38.p7

  • Human Ortholog
    SLCO1B7, solute carrier organic anion transporter family member 1B7 (putative)
    Orthology source: HGNC
  • Synonyms
    LST3, LST-3, LST-3TM12, SLC21A21
  • Links
    NCBI Gene ID: 338821
    neXtProt AC: NX_G3V0H7
    UniProt: G3V0H7

  • Chr Location
    12p12.2; chr12:21015696-21090106 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display slight abnormalities in blood chemistry and are resistant to injury induced by some classes of hepatotoxins.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000025596 VEGA Gene Model | MGI Sequence Detail 57129 C57BL/6J ±  kb
    transcript OTTMUST00000062963 VEGA | MGI Sequence Detail 3307 Not Applicable  
    polypeptide OTTMUSP00000031099 VEGA | MGI Sequence Detail 689 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      590 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 24
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1351894, MGI:1925925
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:62737 Ogura K, et al., Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1). Biochem Biophys Res Commun. 2000 Jun 7;272(2):563-70
    • Latest
      J:243127 Sissung TM, et al., Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx. Mol Cancer Res. 2017 Aug;15(8):1096-1105

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory