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Slco1a4 Gene Detail
Summary
  • Symbol
    Slco1a4
  • Name
    solute carrier organic anion transporter family, member 1a4
  • Synonyms
    Oatp1a4, Oatp2, Slc21a5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351896
    NCBI Gene: 28250
  • Gene Overview
    MyGene.info: SLCO1A2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:141805440-141856199 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 72.90 cM, cytoband G1-G3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    719 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351896
protein coding gene Chr6:141805438-141856284 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031455
protein coding gene Chr6:146582113-146641108 (-)
A/J MGP_AJ_G0031430
protein coding gene Chr6:140806267-140859001 (-)
AKR/J MGP_AKRJ_G0031358
protein coding gene Chr6:144999946-145054021 (-)
BALB/cJ MGP_BALBcJ_G0031437
protein coding gene Chr6:140599342-140652777 (-)
C3H/HeJ MGP_C3HHeJ_G0031159
protein coding gene Chr6:145058907-145112726 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031899
protein coding gene Chr6:150578837-150637333 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030527
protein coding gene Chr6:144604667-144673624 (-)
CBA/J MGP_CBAJ_G0031119
protein coding gene Chr6:156310267-156370651 (-)
DBA/2J MGP_DBA2J_G0031276
protein coding gene Chr6:139613589-139669910 (-)
FVB/NJ MGP_FVBNJ_G0031227
protein coding gene Chr6:138405247-138459414 (-)
LP/J MGP_LPJ_G0031360
protein coding gene Chr6:146724668-146782570 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031267
protein coding gene Chr6:160204286-160258842 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031931
protein coding gene Chr6:144824955-144877477 (-)
PWK/PhJ MGP_PWKPhJ_G0030254
protein coding gene Chr6:138126239-138178465 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030078
protein coding gene Chr6:143041649-143098784 (-)
WSB/EiJ MGP_WSBEiJ_G0030620
protein coding gene Chr6:145473160-145534359 (-)



Homology
more
  • Human Ortholog
    SLCO1A2, solute carrier organic anion transporter family member 1A2
  • Vertebrate Orthologs
    2
  • Human Ortholog
    SLCO1A2, solute carrier organic anion transporter family member 1A2
    Orthology source: HGNC
  • Synonyms
    OATP, OATP1A2, OATP-A, SLC21A3
  • Links
    NCBI Gene ID: 6579
    neXtProt AC: NX_P46721
    UniProt: P46721

  • Chr Location
    12p12.1; chr12:21264600-21403657 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired organic anion transporter activity and urinary metabolomic profiles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030237 Ensembl Gene Model | MGI Sequence Detail 50760 C57BL/6J ±  kb
    transcript ENSMUST00000032364 Ensembl | MGI Sequence Detail 2252 Not Applicable  
    polypeptide ENSMUSP00000032364 Ensembl | MGI Sequence Detail 670 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141469
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:67607 Ogura K, et al., Genomic organization and tissue-specific expression of splice variants of mouse organic anion transporting polypeptide 2. Biochem Biophys Res Commun. 2001 Feb 23;281(2):431-9
    • Latest
      J:243127 Sissung TM, et al., Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx. Mol Cancer Res. 2017 Aug;15(8):1096-1105

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory