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Slco1a4
Gene Detail
 Symbol
Name
ID
Slco1a4
solute carrier organic anion transporter family, member 1a4
MGI:1351896
Synonyms Oatp1a4, Oatp2, Slc21a5
Feature Type protein coding gene
Genetic Map
Chromosome 6
72.90 cM, cytoband G1-G3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:141805440-141856199 bp, - strand
From VEGA annotation of GRCm38

  50760 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:130782  Vertebrate Homology Class
1 mouse; 1 rat

Gene Tree: Slco1a4

Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired organic anion transporter activity and urinary metabolomic profiles.
 
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process anion transport, bile acid and bile salt transport, ...
Component integral component of membrane, membrane, ...
Function bile acid transmembrane transporter activity, organic anion transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (74)    Tissues (27)    Images (20)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 74
cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036818 (Evidence)
Ensembl Gene ModelENSMUSG00000030237 (Evidence)
Entrez Gene28250 (Evidence)
UniGene255586
DFCITC1585225, TC1646634
DoTSDT.55279786, DT.87047112
NIA Mouse Gene IndexU027999, U367579
Consensus CDS ProjectCCDS39690.1
International Mouse Knockout Project StatusSlco1a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036818 VEGA Gene Model | MGI Sequence Detail 50760 C57BL/6J ±  kb
transcript OTTMUST00000094526 VEGA | MGI Sequence Detail 3823 Not Applicable 
polypeptide OTTMUSP00000052599 VEGA | MGI Sequence Detail 670 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(720 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002350 Kazal domain
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR004156 Organic anion transporter polypeptide OATP
Protein Ontology PR:000015966 solute carrier organic anion transporter family member 1A4
References (Earliest) J:67607 Ogura K, et al., Genomic organization and tissue-specific expression of splice variants of mouse organic anion transporting polypeptide 2. Biochem Biophys Res Commun. 2001 Feb 23;281(2):431-9
(Latest) J:201704 Zhang Y, et al., Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism. Biochem Pharmacol. 2013 Aug 1;86(3):437-45
All references(40)
Other
accession IDs
MGI:2141469

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory