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Slco1a1
Gene Detail
 Symbol
Name
ID
Slco1a1
solute carrier organic anion transporter family, member 1a1
MGI:1351891
Synonyms Oatp1, Oatp1a1, Slc21a1
Feature Type protein coding gene
Genetic Map
Chromosome 6
73.09 cM, cytoband A3-A5
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:141907282-141946962 bp, - strand
From VEGA annotation of GRCm38

  39681 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137261  Vertebrate Homology Class
1 mouse; 1 rat

Gene Tree: Slco1a1

Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired organic anion transporter activity and urinary metabolomic profiles.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process ion transmembrane transport, ion transport, ...
Component basolateral plasma membrane, integral component of membrane, ...
Function organic anion transmembrane transporter activity, transporter activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (85)    Tissues (56)    Images (21)
Theiler Stages: 23, 26, 28
Assay TypeResults
RNA in situ 85
cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(31) cDNA(30) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036867 (Evidence)
Ensembl Gene ModelENSMUSG00000041698 (Evidence)
Entrez Gene28248 (Evidence)
UniGene103665
DFCITC1582607, TC1742392
DoTSDT.87048465, DT.101291304
NIA Mouse Gene IndexU028000
Consensus CDS ProjectCCDS39691.1
International Mouse Knockout Project StatusSlco1a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036867 VEGA Gene Model | MGI Sequence Detail 39681 C57BL/6J ±  kb
transcript OTTMUST00000094700 VEGA | MGI Sequence Detail 3395 Not Applicable 
polypeptide OTTMUSP00000052723 VEGA | MGI Sequence Detail 670 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(298 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002350 Kazal domain
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR004156 Organic anion transporter polypeptide OATP
Protein Ontology PR:000015965 solute carrier organic anion transporter family member 1A1
References (Earliest) J:59386 Hagenbuch B, et al., Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X. Biochem J. 2000 Jan 1;345 Pt 1:115-20
(Latest) J:185731 Cui JY, et al., RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development. Toxicol Sci. 2012 Jun;127(2):592-608
All references(39)
Other
accession IDs
MGI:1351890

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory