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Slco1a1 Gene Detail
Summary
  • Symbol
    Slco1a1
  • Name
    solute carrier organic anion transporter family, member 1a1
  • Synonyms
    Oatp1, Oatp1a1, Slc21a1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351891
    NCBI Gene: 28248
  • Gene Overview
    MyGene.info: SLCO1A2
Location & Maps
more
  • Sequence Map
    Chr6:141907282-141946962 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39681 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 73.09 cM, cytoband A3-A5
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    SLCO1A2, solute carrier organic anion transporter family member 1A2
  • Vertebrate Orthologs
    2
  • Human Ortholog
    SLCO1A2, solute carrier organic anion transporter family member 1A2
    Orthology source: HGNC
  • Synonyms
    OATP, OATP1A2, OATP-A, SLC21A3
  • Links
    NCBI Gene ID: 6579
    neXtProt AC: NX_P46721

  • Chr Location
    12p12; chr12:21264600-21403657 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Genomic Mutations
    1 involving Slco1a1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit impaired organic anion transporter activity and urinary metabolomic profiles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036867 VEGA Gene Model | MGI Sequence Detail 39681 C57BL/6J ±  kb
transcript OTTMUST00000094700 VEGA | MGI Sequence Detail 3395 Not Applicable  
polypeptide OTTMUSP00000052723 VEGA | MGI Sequence Detail 670 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    294 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000015965 solute carrier organic anion transporter family member 1A1
  • InterPro Domains
    IPR002350 Kazal domain
    IPR020846 Major facilitator superfamily domain
    IPR004156 Organic anion transporter polypeptide OATP
Molecular
Reagents
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  • All nucleic 31
    cDNA 30
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1351890
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:59386 Hagenbuch B, et al., Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X. Biochem J. 2000 Jan 1;345 Pt 1:115-20
  • Latest
    J:224195 Zhang Y, et al., Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice. PLoS One. 2012;7(4):e34522

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory