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Slco2b1 Gene Detail
Summary
  • Symbol
    Slco2b1
  • Name
    solute carrier organic anion transporter family, member 2b1
  • Synonyms
    OATP-B, Slc21a9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351872
    NCBI Gene: 101488
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:99307011-99360547 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.11 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    712 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351872
 protein coding gene Chr7:99307011-99360547 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032554
 protein coding gene Chr7:102473978-102529461 (-)
A/J MGP_AJ_G0032528
 protein coding gene Chr7:99916333-99970729 (-)
AKR/J MGP_AKRJ_G0032464
 protein coding gene Chr7:102295399-102351658 (-)
BALB/cJ MGP_BALBcJ_G0032539
 protein coding gene Chr7:99596241-99649874 (-)
C3H/HeJ MGP_C3HHeJ_G0032254
 protein coding gene Chr7:102653136-102710286 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033037
 protein coding gene Chr7:106383879-106441781 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030032
 protein coding gene Chr7:102340180-102393526 (-)
CAST/EiJ MGP_CASTEiJ_G0031581
 protein coding gene Chr7:94186625-94242878 (-)
CBA/J MGP_CBAJ_G0032221
 protein coding gene Chr7:110045958-110105624 (-)
DBA/2J MGP_DBA2J_G0032373
 protein coding gene Chr7:98250706-98304555 (-)
FVB/NJ MGP_FVBNJ_G0032330
 protein coding gene Chr7:98042320-98097953 (-)
LP/J MGP_LPJ_G0032462
 protein coding gene Chr7:103789023-103869310 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032362
 protein coding gene Chr7:111482437-111537515 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033059
 protein coding gene Chr7:101568110-101622451 (-)
PWK/PhJ MGP_PWKPhJ_G0031299
 protein coding gene Chr7:91347875-91402342 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031142
 protein coding gene Chr7:88869246-88923902 (-)
WSB/EiJ MGP_WSBEiJ_G0031698
 protein coding gene Chr7:102240622-102299816 (-)



Homology
more
  • Human Ortholog
    SLCO2B1, solute carrier organic anion transporter family member 2B1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLCO2B1, solute carrier organic anion transporter family member 2B1
  • Synonyms
    OATP2B1, OATPB, OATP-B, SLC21A9
  • Links
    NCBI Gene ID: 11309
    neXtProt AC: NX_O94956
    UniProt: O94956

  • Chr Location
    11q13.4; chr11:75100563-75206549 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele develop to adulthood normally but show increased blood urea nitrogen level and decreased absorption of fluvastatin, a known SLCO2B1 substrate drug.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    13
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 101488 NCBI Gene Model | MGI Sequence Detail 53537 C57BL/6J ±  kb
    transcript NM_175316 RefSeq | MGI Sequence Detail 4381 C57BL/6  
    polypeptide Q8BXB6 UniProt | EBI | MGI Sequence Detail 683 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2141865, MGI:2142064
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:327622 Unlu G, et al., Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability. Mol Cell. 2022 Aug 4;82(15):2832-2843.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory