Pdxk MGI Mouse Gene Detail - MGI:1351869 - pyridoxal (pyridoxine, vitamin B6) kinase

Pdxk Gene Detail

Symbol

Pdxk
Name

pyridoxal (pyridoxine, vitamin B6) kinase
Synonyms

2310036D04Rik

Feature Type

protein coding gene
IDs

MGI:1351869
NCBI Gene: 216134
Gene Overview

MyGene.info: PDXK

Sequence Map

Chr10:78436744-78464975 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

28232 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

3 experiments

Human Ortholog

PDXK, pyridoxal (pyridoxine, vitamin B6) kinase

Vertebrate Orthologs

12

Human Ortholog

PDXK, pyridoxal (pyridoxine, vitamin B6) kinase
Orthology source: HomoloGene, HGNC
Synonyms

C21orf124, C21orf97, HEL-S-1a, PKH, PNK, PRED79
Links

HGNC:8819

NCBI Gene ID: 8566

neXtProt AC: NX_O00764
Chr Location

21q22.3; chr21:43719097-43762307 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 2731
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;3 zebrafish;1 frog, western clawed
HCOP

human homology predictions: PDXK
Gene Tree

Pdxk

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References

2 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Gene trapped

1
Targeted

6
Genomic Mutations

3 involving Pdxk

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All GO Annotations

30
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

388
Tissues

185
cDNA Data

16
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase pdxk

ZFIN pdxka

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Pdxk interacts with 331 markers (Mir1a-1, Mir1a-2, Mir15a, ...) View All

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All Sequences

41
RefSeq

2
UniProt

2
CCDS

CCDS23965.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000020292	VEGA Gene Model \| MGI Sequence Detail	28232	C57BL/6J	± kb
transcript	OTTMUST00000048157	VEGA \| MGI Sequence Detail	5124	Not Applicable
polypeptide	OTTMUSP00000021998	VEGA \| MGI Sequence Detail	312	Not Applicable

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SNPs within 2kb

109 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000012524 pyridoxal kinase
EC

2.7.1.35
InterPro Domains

IPR013749 Pyridoxamine kinase/Phosphomethylpyrimidine kinase

IPR004625 Pyridoxine kinase

IPR029056 Ribokinase-like

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All nucleic 29

Genomic 11

cDNA 17

Primer pair 1

Microarray probesets 6

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MGI:1916848, MGI:2143917, MGI:3034915

Summaries

All 40

Developmental Gene Expression 5

Diseases 2

Gene Ontology 4

Phenotypes 20
Earliest

J:59327 Wiltshire T, et al., Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21. Genome Res. 1999 Dec;9(12):1214-22
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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