Slco1a5
Gene Detail

Symbol Name ID

Slco1a5 solute carrier organic anion transporter family, member 1a5 MGI:1351865

Synonyms

Oatp3, Slc21a7

Feature Type

protein coding gene

Genetic Map

Chromosome 6

73.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:142234227-142322981 bp, - strand From VEGA annotation of GRCm38   88755 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Slco1a5 ± 2 cM)

Gene Tree: Slco1a5

Human ortholog

SLCO1A2 solute carrier organic anion transporter family, member 1A2 NCBI Gene ID 6579
Human Synonyms: OATP, OATP1A2, OATP-A, SLC21A3
Human Chr12:21417534-21548371 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous mutation of this gene results in decreased percentage of CD8 ells and increased percentage of B cells in the peripheral blood.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	bile acid and bile salt transport, intestinal absorption, ...
Component	brush border membrane, integral to membrane, ...
Function	bile acid transmembrane transporter activity, monocarboxylic acid transmembrane transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (150)    Tissues (100)    Images (23)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	150

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(19) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000024218 (Evidence)
Ensembl Gene Model	ENSMUSG00000063975 (Evidence)
Entrez Gene	108096 (Evidence)
UniGene	206599
DFCI	TC1583452, TC1589057, TC1664309
DoTS	DT.521906, DT.91322365, DT.99854148
NIA Mouse Gene Index	U028002
Consensus CDS Project	CCDS57464.1
International Mouse Knockout Project Status	Slco1a5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024218	VEGA Gene Model | MGI Sequence Detail	88755	C57BL/6J
transcript	OTTMUST00000059262	VEGA | MGI Sequence Detail	2586	Not Applicable
polypeptide	OTTMUSP00000062819	VEGA | MGI Sequence Detail	670	Not Applicable

All sequences(41) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(508 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011497	Kazal-type serine protease inhibitor domain
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
InterPro	IPR004156	Organic anion transporter polypeptide OATP
InterPro	IPR002350	Proteinase inhibitor I1, Kazal
Protein Ontology	PR:000015967	solute carrier organic anion transporter family member 1A5

References

(Earliest) J:66643 Walters HC, et al., Expression, transport properties, and chromosomal location of organic anion transporter subtype 3. Am J Physiol Gastrointest Liver Physiol. 2000 Dec;279(6):G1188-200
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(29)