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Eif3m Gene Detail
Summary
  • Symbol
    Eif3m
  • Name
    eukaryotic translation initiation factor 3, subunit M
  • Synonyms
    Ga17, Pcid1, Tango7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351744
    NCBI Gene: 98221
  • Gene Overview
    MyGene.info: EIF3M
Location & Maps
more
  • Sequence Map
    Chr2:104999656-105017080 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17425 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 55.06 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EIF3M, eukaryotic translation initiation factor 3 subunit M
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EIF3M, eukaryotic translation initiation factor 3 subunit M
    Orthology source: HGNC, HomoloGene
  • Synonyms
    B5, GA17, hfl-B5, PCID1, TANGO7
  • Links
    NCBI Gene ID: 10480
    neXtProt AC: NX_Q7L2H7

  • Chr Location
    11p13; chr11:32583767-32604498 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4639
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: EIF3M
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Eif3m
  • Incidental Mutations
Mice homozygous for a targeted allele exhibit embryonic lethality. Mice heterozygous for this allele exhibit decreased body weight and altered organ weights.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014975 VEGA Gene Model | MGI Sequence Detail 17425 C57BL/6J ±  kb
transcript OTTMUST00000035551 VEGA | MGI Sequence Detail 1283 Not Applicable  
polypeptide OTTMUSP00000015928 VEGA | MGI Sequence Detail 374 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    271 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006985 eukaryotic translation initiation factor 3 subunit M
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR027528 Eukaryotic translation initiation factor 3 subunit M
    IPR000717 Proteasome component (PCI) domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 4
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:58552 Gawin B, et al., A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1. Genome Res. 1999 Nov;9(11):1074-86
  • Latest
    J:204915 Zeng L, et al., The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. J Biol Chem. 2013 Oct 18;288(42):30087-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory