About   Help   FAQ
Take the Alliance for Genomic Resources User Survey
Abca8b Gene Detail
Summary
  • Symbol
    Abca8b
  • Name
    ATP-binding cassette, sub-family A (ABC1), member 8b
  • Synonyms
    Abca8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351668
    NCBI Gene: 27404
  • Gene Overview
    MyGene.info: ABCA8
Location & Maps
more
  • Sequence Map
    Chr11:109932190-109995845 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      63656 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 72.88 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ABCA8, ATP binding cassette subfamily A member 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ABCA8, ATP binding cassette subfamily A member 8
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 10351
    neXtProt AC: NX_O94911

  • Chr Location
    17q24; chr17:68867287-68955408 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    117
  • Tissues
    110
  • cDNA Data
    13
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003354 VEGA Gene Model | MGI Sequence Detail 63656 C57BL/6J ±  kb
transcript OTTMUST00000007052 VEGA | MGI Sequence Detail 7423 Not Applicable  
polypeptide OTTMUSP00000003358 VEGA | MGI Sequence Detail 1620 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    103 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000003546 ATP-binding cassette sub-family A member 8
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR026082 ABC transporter A, ABCA
    IPR017871 ABC transporter, conserved site
    IPR003439 ABC transporter-like
    IPR020846 Major facilitator superfamily domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:60841 Schriml LM, et al., Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus. Genomics. 2000 Feb 15;64(1):24-31
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory