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Abcb8
Gene Detail
Symbol

Name
ID
Abcb8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
MGI:1351667
Synonyms
4833412N02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
11.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:24393663-24410054 bp, + strand
From VEGA annotation of GRCm38

  16392 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5203  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ABCB8
Protein SuperFamily: ABC-type transport system, bifunctional permease/ATPase, subfamily B
Gene Tree: Abcb8

Human
homologs
ABCB8, ATP-binding cassette, sub-family B (MDR/TAP), member 8
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 11194
neXtProt AC: NX_Q9NUT2

Human Synonyms: EST328128, MABC1, M-ABC1

Human Chr (Location): 7q36; chr7:151028422-151047782 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Inducible cardiac specific deletion results in mild cardiomyopathy, mitochondrial defects and elevated heart mitochondrial iron levels.
 
Interactions
Abcb8 interacts with 82 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process transmembrane transport, transport
Component integral component of membrane, membrane, ...
Function ATPase activity, ATPase activity, coupled to transmembrane movement of substances, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (137)    Tissues (123)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 137
cDNA source data(95)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase abcb8    NEW 
Molecular
reagents
All nucleic(96) cDNA(96)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000024149 (Evidence)
Ensembl Gene Model ENSMUSG00000028973 (Evidence)
Entrez Gene 74610 (Evidence)
UniGene 283914
DFCI TC1606453, TC1666048, TC1572733, TC1604705
DoTS DT.101373937, DT.489260, DT.94260532, DT.101373938
NIA Mouse Gene Index U005360
Consensus CDS Project CCDS19118.1
International Mouse Phenotyping Consortium Status Abcb8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024149 VEGA Gene Model | MGI Sequence Detail 16392 C57BL/6J ±  kb
transcript OTTMUST00000059077 VEGA | MGI Sequence Detail 3074 Not Applicable 
polypeptide OTTMUSP00000028705 VEGA | MGI Sequence Detail 717 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(177 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR011527 ABC transporter, transmembrane domain, type 1
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000032495 ATP-binding cassette sub-family B member 8, mitochondrial
References
(Earliest) J:60841 Schriml LM, et al., Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus. Genomics. 2000 Feb 15;64(1):24-31
(Latest) J:207999 Ichikawa Y, et al., Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation. J Clin Invest. 2014 Feb 3;124(2):617-30
All references(39)
Other
accession IDs
MGI:1921860, MGI:2140747

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory