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Ptdss2 Gene Detail
Summary
  • Symbol
    Ptdss2
  • Name
    phosphatidylserine synthase 2
  • Synonyms
    PSS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351664
    NCBI Gene: 27388
Location & Maps
more
  • Sequence Map
    Chr7:141122382-141157021 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34640 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PTDSS2, phosphatidylserine synthase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTDSS2, phosphatidylserine synthase 2
    Orthology source: HomoloGene
  • Synonyms
    PSS2
  • Links
    NCBI Gene ID: 81490
    neXtProt AC: NX_Q9BVG9

  • Chr Location
    11p15.5; chr11:448271-491399 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    113
  • Gene trapped
    109
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Ptdss2
  • Incidental Mutations
Disruption of this gene causes infertility in about 10% of homozygous males. The remaining males and all females were fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037303 VEGA Gene Model | MGI Sequence Detail 34640 C57BL/6J ±  kb
transcript OTTMUST00000096269 VEGA | MGI Sequence Detail 3039 Not Applicable  
polypeptide OTTMUSP00000053763 VEGA | MGI Sequence Detail 473 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    131 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 22
    cDNA 21
    Primer pair 1

    Microarray probesets 11
Other
Accession IDs
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MGI:2141985, MGI:2142082
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 17
  • Earliest
    J:57025 Stone SJ, et al., Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2. Biochem J. 1999 Aug 15;342(Pt 1):57-64
  • Latest
    J:190989 Kimura AK, et al., Phosphatidylserine synthase 2: high efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid. J Lipid Res. 2013 Jan;54(1):214-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory