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Shroom3
Gene Detail
Symbol

Name
ID
Shroom3
shroom family member 3
MGI:1351655
Synonyms
D5Ertd287e, Shrm, Shrm3
Feature Type
protein coding gene
Genetic Map
Chromosome 5
47.29 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:92683435-92965318 bp, + strand
From VEGA annotation of GRCm38

  281884 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9263  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: SHROOM3
Gene Tree: Shroom3

Human
homologs
SHROOM3, shroom family member 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 57619
neXtProt AC: NX_Q8TF72

Human Synonyms: APXL3, MSTP013, SHRM, ShrmL

Human Chr (Location): 4q21.1; chr4:76435100-76783253 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(201) : Chemically induced (ENU)(1) Gene trapped(198) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this locus results in failed neural tube closure leading to exencephaly, acrania, facial clefting, and spina bifida. Homozygotes develop to term but die either at birth or shortly thereafter.
 
Interactions
Shroom3 interacts with 182 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process actin cytoskeleton organization, cell morphogenesis, ...
Component adherens junction, apical junction complex, ...
Function actin binding, actin filament binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (122)    Tissues (40)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 66
In situ reporter (knock in) 54
Western blot 2
cDNA source data(73)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase shroom3 ; ZFIN shroom3    NEW 
Molecular
reagents
All nucleic(75) cDNA(74) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000036945 (Evidence)
Ensembl Gene Model ENSMUSG00000029381 (Evidence)
Entrez Gene 27428 (Evidence)
UniGene 46014
DFCI TC1594807, TC1597093, TC1713112, TC1600114, TC1606407, TC1675385, TC1610610, TC1663563
NIA Mouse Gene Index U005809
Consensus CDS Project CCDS39154.1, CCDS39155.1
International Mouse Phenotyping Consortium Status Shroom3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036945 VEGA Gene Model | MGI Sequence Detail 281884 C57BL/6J ±  kb
transcript OTTMUST00000094929 VEGA | MGI Sequence Detail 6765 Not Applicable 
polypeptide OTTMUSP00000052929 VEGA | MGI Sequence Detail 1980 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(2288 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014800 Apx/shroom, ASD1
InterPro IPR014799 Apx/shroom, ASD2
InterPro IPR001478 PDZ domain
Protein Ontology PR:000014856 protein Shroom3
References
(Earliest) J:58691 Hildebrand JD, et al., Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice. Cell. 1999 Nov 24;99(5):485-97
(Latest) J:219576 McGreevy EM, et al., Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure. Biol Open. 2015;4(2):186-96
All references(57)
Other
accession IDs
MGI:1098648, MGI:2141015

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory