About   Help   FAQ
Shroom3 Gene Detail
Summary
  • Symbol
    Shroom3
  • Name
    shroom family member 3
  • Synonyms
    D5Ertd287e, Shrm, Shrm3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351655
    NCBI Gene: 27428
  • Gene Overview
    MyGene.info: SHROOM3
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:92683435-92965318 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 47.29 cM, cytoband E3
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2276 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351655
protein coding gene Chr5:92683435-92965759 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029756
protein coding gene Chr5:93876608-94174341 (+)
A/J MGP_AJ_G0029722
protein coding gene Chr5:90139760-90427959 (+)
AKR/J MGP_AKRJ_G0029668
protein coding gene Chr5:93109927-93410490 (+)
BALB/cJ MGP_BALBcJ_G0029732
protein coding gene Chr5:91018321-91308351 (+)
C3H/HeJ MGP_C3HHeJ_G0029455
protein coding gene Chr5:93498818-93791379 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030186
protein coding gene Chr5:97594278-97912902 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027422
protein coding gene Chr5:85778696-86065416 (+)
CAST/EiJ MGP_CASTEiJ_G0028865
protein coding gene Chr5:92876692-93178415 (+)
CBA/J MGP_CBAJ_G0029425
protein coding gene Chr5:101010645-101328904 (+)
DBA/2J MGP_DBA2J_G0029569
protein coding gene Chr5:90188954-90480701 (+)
FVB/NJ MGP_FVBNJ_G0029528
protein coding gene Chr5:89047320-89336492 (+)
LP/J MGP_LPJ_G0029657
protein coding gene Chr5:94237949-94544581 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029557
protein coding gene Chr5:105890681-106210500 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030220
protein coding gene Chr5:92626935-92922959 (+)
PWK/PhJ MGP_PWKPhJ_G0028584
protein coding gene Chr5:89253064-89544935 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028419
protein coding gene Chr5:91963934-92262136 (+)
WSB/EiJ MGP_WSBEiJ_G0028944
protein coding gene Chr5:93085860-93388881 (+)



Homology
more
  • Human Ortholog
    SHROOM3, shroom family member 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SHROOM3, shroom family member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APXL3, MSTP013, SHRM, ShrmL
  • Links
    NCBI Gene ID: 57619
    neXtProt AC: NX_Q8TF72
    UniProt: Q8TF72

  • Chr Location
    4q21.1; chr4:76435100-76783253 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this locus results in failed neural tube closure leading to exencephaly, acrania, facial clefting, and spina bifida. Homozygotes develop to term but die either at birth or shortly thereafter.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029381 Ensembl Gene Model | MGI Sequence Detail 281884 C57BL/6J ±  kb
    transcript ENSMUST00000113055 Ensembl | MGI Sequence Detail 6765 Not Applicable  
    polypeptide ENSMUSP00000108678 Ensembl | MGI Sequence Detail 1980 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 79
      cDNA 77
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1098648, MGI:2141015
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 16
      Gene Ontology 7
      Phenotypes 29
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:264113 Lopez-Escobar B, et al., The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate. Development. 2018 May 8;145(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory