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Slc14a1
Gene Detail
Symbol

Name
ID
Slc14a1
solute carrier family 14 (urea transporter), member 1
MGI:1351654
Synonyms
2610507K20Rik, 3021401A05Rik, UT-B
Feature Type
protein coding gene
Genetic Map
Chromosome 18
52.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:78100091-78142119 bp, - strand
From VEGA annotation of GRCm38

  42029 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9285  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SLC14A1
Protein SuperFamily: urea transporter
Gene Tree: Slc14a1

Human
homologs
SLC14A1, solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6563
neXtProt AC: NX_Q13336

Human Synonyms: HsT1341, HUT11, JK, RACH1, RACH2, UT1, UT-B1, UTE

Human Chr (Location): 18q11-q12; chr18:45723756-45752520 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from CvDC )
 
Mice homozygous for disruptions in this gene display a grossly normal phenotype although they have an inability to concentrate urea in urine.
 
Interactions
Slc14a1 interacts with 233 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (288)    Tissues (204)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 288
cDNA source data(38)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(38) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000034695 (Evidence)
Ensembl Gene Model ENSMUSG00000059336 (Evidence)
Entrez Gene 108052 (Evidence)
UniGene 33832
DFCI TC1689310, TC1577026
DoTS DT.101360211, DT.110770935, DT.91311285
NIA Mouse Gene Index U038587
Consensus CDS Project CCDS29360.1, CCDS50330.1
International Mouse Phenotyping Consortium Status Slc14a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034695 VEGA Gene Model | MGI Sequence Detail 42029 C57BL/6J ±  kb
transcript OTTMUST00000088107 VEGA | MGI Sequence Detail 2217 Not Applicable 
polypeptide OTTMUSP00000048005 VEGA | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(6) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(260 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004937 Urea transporter
Protein Ontology PR:000014938 urea transporter 1
References
(Earliest) J:59121 Fenton RA, et al., The murine urea transporter genes Slc14a1 and Slc14a2 occur in tandem on chromosome 18. Cytogenet Cell Genet. 1999;87(1-2):95-6
(Latest) J:216586 Ren H, et al., Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters. Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1363-72
All references(42)
Other
accession IDs
MGI:1917932, MGI:1919392

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory