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Slc14a1 Gene Detail
Summary
  • Symbol
    Slc14a1
  • Name
    solute carrier family 14 (urea transporter), member 1
  • Synonyms
    2610507K20Rik, 3021401A05Rik, UT-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351654
    NCBI Gene: 108052
  • Gene Overview
    MyGene.info: SLC14A1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:78100091-78142119 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42029 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 52.49 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SLC14A1, solute carrier family 14 member 1 (Kidd blood group)
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC14A1, solute carrier family 14 member 1 (Kidd blood group)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HsT1341, HUT11, JK, RACH1, RACH2, UT1, UT-B1, UTE
  • Links
    NCBI Gene ID: 6563
    neXtProt AC: NX_Q13336
    UniProt: Q13336

  • Chr Location
    18q12.3; chr18:45724123-45752520 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a grossly normal phenotype although they have an inability to concentrate urea in urine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034695 VEGA Gene Model | MGI Sequence Detail 42029 C57BL/6J ±  kb
    transcript OTTMUST00000088107 VEGA | MGI Sequence Detail 2217 Not Applicable  
    polypeptide OTTMUSP00000048005 VEGA | MGI Sequence Detail 440 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      260 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 39
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
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    MGI:1917932, MGI:1919392
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:59121 Fenton RA, et al., The murine urea transporter genes Slc14a1 and Slc14a2 occur in tandem on chromosome 18. Cytogenet Cell Genet. 1999;87(1-2):95-6
    • Latest
      J:216586 Ren H, et al., Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters. Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1363-72

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory