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Slc14a2 Gene Detail
Summary
  • Symbol
    Slc14a2
  • Name
    solute carrier family 14 (urea transporter), member 2
  • Synonyms
    UT-A3, UT-A5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351653
    NCBI Gene: 27411
  • Gene Overview
    MyGene.info: SLC14A2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr18:78146940-78209094 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      62155 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 52.53 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC14A2, solute carrier family 14 member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC14A2, solute carrier family 14 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HUT2, hUT-A6, UT2, UTA, UT-A2, UTR
  • Links
    NCBI Gene ID: 8170
    neXtProt AC: NX_Q15849
    UniProt: Q15849

  • Chr Location
    18q12.3; chr18:45196357-45683686 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice lacking the collecting duct specific isoforms display decreased urea permeability and urine osmolality and increased urine flow.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    180
  • Tissues
    137
  • cDNA Data
    12
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024552 Ensembl Gene Model | MGI Sequence Detail 62155 C57BL/6J ±  kb
    transcript ENSMUST00000025434 Ensembl | MGI Sequence Detail 2793 Not Applicable  
    polypeptide ENSMUSP00000025434 Ensembl | MGI Sequence Detail 930 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2983 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:59121 Fenton RA, et al., The murine urea transporter genes Slc14a1 and Slc14a2 occur in tandem on chromosome 18. Cytogenet Cell Genet. 1999;87(1-2):95-6
    • Latest
      J:243840 Gerl K, et al., Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development. Am J Pathol. 2017 Jul;187(7):1496-1511
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory