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Slc14a2 Gene Detail
Summary
  • Symbol
    Slc14a2
  • Name
    solute carrier family 14 (urea transporter), member 2
  • Synonyms
    UT-A3, UT-A5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351653
    NCBI Gene: 27411
  • Gene Overview
    MyGene.info: SLC14A2
Location & Maps
more
  • Sequence Map
    Chr18:78146940-78209094 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      62155 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 52.53 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC14A2, solute carrier family 14 member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC14A2, solute carrier family 14 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HUT2, hUT-A6, UT2, UTA, UT-A2, UTR
  • Links
    NCBI Gene ID: 8170
    neXtProt AC: NX_Q15849

  • Chr Location
    18q12.3; chr18:45212957-45683107 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Targeted
    5
  • Transposon induced
    2
  • Genomic Mutations
    1 involving Slc14a2
  • Incidental Mutations
Homozygous mice lacking the collecting duct specific isoforms display decreased urea permeability and urine osmolality and increased urine flow.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024552 Ensembl Gene Model | MGI Sequence Detail 62155 C57BL/6J ±  kb
transcript ENSMUST00000025434 Ensembl | MGI Sequence Detail 2793 Not Applicable  
polypeptide ENSMUSP00000025434 Ensembl | MGI Sequence Detail 930 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2983 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:59121 Fenton RA, et al., The murine urea transporter genes Slc14a1 and Slc14a2 occur in tandem on chromosome 18. Cytogenet Cell Genet. 1999;87(1-2):95-6
  • Latest
    J:200103 Chiang YJ, et al., CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-Cell adhesion and migration. PLoS One. 2013;8(4):e61761

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory