Slc14a2 MGI Mouse Gene Detail - MGI:1351653 - solute carrier family 14 (urea transporter), member 2

Symbol

Slc14a2
Name

solute carrier family 14 (urea transporter), member 2
Synonyms

UT-A3, UT-A5

Feature Type

protein coding gene
IDs

MGI:1351653
NCBI Gene: 27411
Gene Overview

MyGene.info: SLC14A2
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr18:78189363-78640157 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 52.53 cM
Mapping Data

2 experiments

SNPs within 2kb

2981 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351653	protein coding gene	Chr18:78189359-78640165 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024584	protein coding gene	Chr18:78955238-79020899 (-)
A/J	MGP_AJ_G0024551	protein coding gene	Chr18:75488400-75554434 (-)
AKR/J	MGP_AKRJ_G0024522	protein coding gene	Chr18:77717355-77783486 (-)
BALB/cJ	MGP_BALBcJ_G0024550	protein coding gene	Chr18:75683147-75745304 (-)
C3H/HeJ	MGP_C3HHeJ_G0024319	protein coding gene	Chr18:77821987-77887598 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024997	protein coding gene	Chr18:81011481-81078653 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022427	protein coding gene	Chr18:74441341-74502757 (-)
CAST/EiJ	MGP_CASTEiJ_G0023791	protein coding gene	Chr18:78150669-78222903 (-)
CBA/J	MGP_CBAJ_G0024288	protein coding gene	Chr18:83917367-83987093 (-)
DBA/2J	MGP_DBA2J_G0024418	protein coding gene	Chr18:75031798-75094732 (-)
FVB/NJ	MGP_FVBNJ_G0024384	protein coding gene	Chr18:74397083-74458573 (-)
LP/J	MGP_LPJ_G0024502	protein coding gene	Chr18:78841610-78906965 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024414	protein coding gene	Chr18:85123396-85190195 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025045	protein coding gene	Chr18:77900242-77968256 (-)
PWK/PhJ	MGP_PWKPhJ_G0023536	protein coding gene	Chr18:75468794-75531917 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023340	protein coding gene	Chr18:78082707-78152386 (-)
WSB/EiJ	MGP_WSBEiJ_G0023855	protein coding gene	Chr18:77848724-77913203 (-)

Human Ortholog

SLC14A2, solute carrier family 14 member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC14A2, solute carrier family 14 member 2
Synonyms

HUT2, hUT-A6, UT2, UTA, UT-A2, UTR
Links

HGNC:10919

NCBI Gene ID: 8170

neXtProt AC: NX_Q15849

UniProt: Q15849
Chr Location

18q12.3; chr18:45196357-45683686 (+) GRCh38.p7

Alliance of Genome Resources

Slc14a2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC14A2
Protein SuperFamily

Urea_transporter
Gene Tree

Slc14a2

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Phenotype Summary

16 phenotypes from 2 alleles in 3 genetic backgrounds
7 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Gene trapped

1
Targeted

5
Transposon induced

2
Genomic Mutations

1 involving Slc14a2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice lacking the collecting duct specific isoforms display decreased urea permeability and urine osmolality and increased urine flow.

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

811
Tissues

137
cDNA Data

13
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc14a2

ZFIN slc14a2

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Slc14a2 interacts with 83 markers (Mir19a, Mir19b-1, Mir19b-2, ...) View All

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All Sequences

56
RefSeq

12
UniProt

6
CCDS

CCDS29361.1, CCDS50331.1, CCDS89283.1, CCDS89284.1

Ensembl

ENSMUSG00000024552 (Evidence)
NCBI Gene

27411

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024552	Ensembl Gene Model \| MGI Sequence Detail	450795	C57BL/6J	± kb
transcript	ENSMUST00000025434	Ensembl \| MGI Sequence Detail	2793	Not Applicable
polypeptide	ENSMUSP00000025434	Ensembl \| MGI Sequence Detail	930	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000014939 urea transporter 2

(term hierarchy)
InterPro Domains

IPR029020 Ammonium/urea transporter

IPR004937 Urea transporter

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All nucleic 13

cDNA 13

Microarray probesets 3

Summaries

All 48

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 16
Earliest

J:59121 Fenton RA, et al., The murine urea transporter genes Slc14a1 and Slc14a2 occur in tandem on chromosome 18. Cytogenet Cell Genet. 1999;87(1-2):95-6
Latest

J:297153 Geng X, et al., The urea transporter UT-A1 plays a predominant role in a urea-dependent urine-concentrating mechanism. J Biol Chem. 2020 Jul 17;295(29):9893-9900

TSS for Slc14a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr153979	Chr18:78640110-78640122 (-)	41 bp
Tssr153978	Chr18:78249623-78249634 (-)	390,528 bp
Tssr153977	Chr18:78249611-78249622 (-)	390,540 bp
Tssr153976	Chr18:78249136-78249192 (-)	390,993 bp
Tssr153975	Chr18:78249104-78249132 (-)	391,039 bp
Tssr153974	Chr18:78249082-78249093 (-)	391,069 bp
Tssr153973	Chr18:78222378-78222391 (-)	417,772 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/14/2021 MGI 6.17