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Slc14a2 Gene Detail
Summary
  • Symbol
    Slc14a2
  • Name
    solute carrier family 14 (urea transporter), member 2
  • Synonyms
    UT-A3, UT-A5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351653
    NCBI Gene: 27411
  • Gene Overview
    MyGene.info: SLC14A2
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:78146148-78596942 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 52.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2988 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351653
 protein coding gene Chr18:78146144-78596950 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024584
 protein coding gene Chr18:78955238-79020899 (-)
A/J MGP_AJ_G0024551
 protein coding gene Chr18:75488400-75554434 (-)
AKR/J MGP_AKRJ_G0024522
 protein coding gene Chr18:77717355-77783486 (-)
BALB/cJ MGP_BALBcJ_G0024550
 protein coding gene Chr18:75683147-75745304 (-)
C3H/HeJ MGP_C3HHeJ_G0024319
 protein coding gene Chr18:77821987-77887598 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024997
 protein coding gene Chr18:81011481-81078653 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022427
 protein coding gene Chr18:74441341-74502757 (-)
CAST/EiJ MGP_CASTEiJ_G0023791
 protein coding gene Chr18:78150669-78222903 (-)
CBA/J MGP_CBAJ_G0024288
 protein coding gene Chr18:83917367-83987093 (-)
DBA/2J MGP_DBA2J_G0024418
 protein coding gene Chr18:75031798-75094732 (-)
FVB/NJ MGP_FVBNJ_G0024384
 protein coding gene Chr18:74397083-74458573 (-)
LP/J MGP_LPJ_G0024502
 protein coding gene Chr18:78841610-78906965 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024414
 protein coding gene Chr18:85123396-85190195 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025045
 protein coding gene Chr18:77900242-77968256 (-)
PWK/PhJ MGP_PWKPhJ_G0023536
 protein coding gene Chr18:75468794-75531917 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023340
 protein coding gene Chr18:78082707-78152386 (-)
WSB/EiJ MGP_WSBEiJ_G0023855
 protein coding gene Chr18:77848724-77913203 (-)



Homology
more
  • Human Ortholog
    SLC14A2, solute carrier family 14 member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC14A2, solute carrier family 14 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HUT2, hUT-A6, UT2, UTA, UT-A2, UTR
  • Links
    NCBI Gene ID: 8170
    neXtProt AC: NX_Q15849
    UniProt: Q15849

  • Chr Location
    18q12.3; chr18:45196357-45683686 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mice lacking the collecting duct specific isoforms display decreased urea permeability and urine osmolality and increased urine flow.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    811
  • Tissues
    137
  • cDNA Data
    13
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024552 Ensembl Gene Model | MGI Sequence Detail 450795 C57BL/6J ±  kb
    transcript ENSMUST00000025434 Ensembl | MGI Sequence Detail 2793 Not Applicable  
    polypeptide ENSMUSP00000025434 Ensembl | MGI Sequence Detail 930 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 3
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:59121 Fenton RA, et al., The murine urea transporter genes Slc14a1 and Slc14a2 occur in tandem on chromosome 18. Cytogenet Cell Genet. 1999;87(1-2):95-6
    • Latest
      J:297153 Geng X, et al., The urea transporter UT-A1 plays a predominant role in a urea-dependent urine-concentrating mechanism. J Biol Chem. 2020 Jul 17;295(29):9893-9900
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    02/23/2021
    MGI 6.16     		The Jackson Laboratory