Slc14a2 MGI Mouse Gene Detail - MGI:1351653 - solute carrier family 14 (urea transporter), member 2

Slc14a2 Gene Detail

Symbol

Slc14a2
Name

solute carrier family 14 (urea transporter), member 2
Synonyms

UT-A3, UT-A5

Feature Type

protein coding gene
IDs

MGI:1351653
NCBI Gene: 27411
Gene Overview

MyGene.info: SLC14A2
Alliance

gene page

Sequence Map

Chr18:78146940-78209094 bp, - strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

62155 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 52.53 cM
Mapping Data

2 experiments

Human Ortholog

SLC14A2, solute carrier family 14 member 2

Vertebrate Orthologs

9

Human Ortholog

SLC14A2, solute carrier family 14 member 2
Orthology source: HomoloGene, HGNC
Synonyms

HUT2, hUT-A6, UT2, UTA, UT-A2, UTR
Links

HGNC:10919

NCBI Gene ID: 8170

neXtProt AC: NX_Q15849

UniProt: Q15849
Chr Location

18q12.3; chr18:45196357-45683686 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 5183
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: SLC14A2
Protein SuperFamily

urea transporter
Gene Tree

Slc14a2

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Phenotype Summary

16 phenotypes from 2 alleles in 3 genetic backgrounds
7 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Targeted

5
Transposon induced

2
Genomic Mutations

1 involving Slc14a2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available

Homozygous mice lacking the collecting duct specific isoforms display decreased urea permeability and urine osmolality and increased urine flow.

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All GO Annotations

8
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

180
Tissues

137
cDNA Data

12
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN slc14a2

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Slc14a2 interacts with 83 markers (Mir19a, Mir19b-1, Mir19b-2, ...) View All

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All Sequences

30
RefSeq

12
UniProt

5
CCDS

CCDS29361.1, CCDS50331.1
UniGene

44158

Ensembl

ENSMUSG00000024552 (Evidence)
NCBI Gene

27411

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024552	Ensembl Gene Model \| MGI Sequence Detail	62155	C57BL/6J	± kb
transcript	ENSMUST00000025434	Ensembl \| MGI Sequence Detail	2793	Not Applicable
polypeptide	ENSMUSP00000025434	Ensembl \| MGI Sequence Detail	930	Not Applicable

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SNPs within 2kb

2983 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000014939 urea transporter 2

(term hierarchy)
InterPro Domains

IPR004937 Urea transporter

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All nucleic 12

cDNA 12

Microarray probesets 3

Summaries

All 37

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 12
Earliest

J:59121 Fenton RA, et al., The murine urea transporter genes Slc14a1 and Slc14a2 occur in tandem on chromosome 18. Cytogenet Cell Genet. 1999;87(1-2):95-6
Latest

J:234570 Lee D, et al., Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy. J Clin Invest. 2016 Apr 1;126(4):1300-10

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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