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Yme1l1 Gene Detail
Summary
  • Symbol
    Yme1l1
  • Name
    YME1-like 1 (S. cerevisiae)
  • Synonyms
    ATP-dependent metalloprotease FtsH1, Ftsh
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351651
    NCBI Gene: 27377
  • Gene Overview
    MyGene.info: YME1L1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:23156369-23199260 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 15.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351651
protein coding gene Chr2:23155442-23199260 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025397
protein coding gene Chr2:20902941-20948992 (+)
A/J MGP_AJ_G0025375
protein coding gene Chr2:20061632-20103979 (+)
AKR/J MGP_AKRJ_G0025344
protein coding gene Chr2:20774412-20818870 (+)
BALB/cJ MGP_BALBcJ_G0025370
protein coding gene Chr2:20165549-20209064 (+)
C3H/HeJ MGP_C3HHeJ_G0025131
protein coding gene Chr2:20690859-20735505 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025814
protein coding gene Chr2:21502630-21553021 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0024594
protein coding gene Chr2:20606251-20652259 (+)
CBA/J MGP_CBAJ_G0025109
protein coding gene Chr2:22326258-22374668 (+)
DBA/2J MGP_DBA2J_G0025242
protein coding gene Chr2:19949479-19992351 (+)
FVB/NJ MGP_FVBNJ_G0025204
protein coding gene Chr2:19729547-19772503 (+)
LP/J MGP_LPJ_G0025328
protein coding gene Chr2:20837922-20882682 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025235
protein coding gene Chr2:22397913-22447576 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025873
protein coding gene Chr2:20676096-20720614 (+)
PWK/PhJ MGP_PWKPhJ_G0024343
protein coding gene Chr2:19779624-19824088 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024143
protein coding gene Chr2:20775980-20815625 (+)
WSB/EiJ MGP_WSBEiJ_G0024664
protein coding gene Chr2:20798687-20845111 (+)



Homology
more
  • Human Ortholog
    YME1L1, YME1 like 1 ATPase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    YME1L1, YME1 like 1 ATPase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FTSH, MEG4, OPA11, PAMP, YME1L
  • Links
    NCBI Gene ID: 10730
    neXtProt AC: NX_Q96TA2
    UniProt: Q96TA2

  • Chr Location
    10p12.1; chr10:27110111-27154802 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31996
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: YME1L1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Yme1l1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null embryos die prior to E13.5, and show a developmental delay from E8.5 to E12.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026775 Ensembl Gene Model | MGI Sequence Detail 42892 C57BL/6J ±  kb
transcript ENSMUST00000028117 Ensembl | MGI Sequence Detail 4707 Not Applicable  
polypeptide ENSMUSP00000028117 Ensembl | MGI Sequence Detail 715 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 141
    cDNA 141

    Microarray probesets 8
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:62529 Coppola M, et al., Identification and characterization of YME1L1, a novel paraplegin-related gene. Genomics. 2000 May 15;66(1):48-54
  • Latest
    J:235613 Hartmann B, et al., Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory