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Tjp3 Gene Detail
Summary
  • Symbol
    Tjp3
  • Name
    tight junction protein 3
  • Synonyms
    ZO-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351650
    NCBI Gene: 27375
  • Gene Overview
    MyGene.info: TJP3
Location & Maps
more
  • Sequence Map
    Chr10:81273207-81291267 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18061 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TJP3, tight junction protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TJP3, tight junction protein 3
    Orthology source: HomoloGene
  • Synonyms
    ZO3, ZO-3
  • Links
    NCBI Gene ID: 27134
    neXtProt AC: NX_O95049

  • Chr Location
    19p13.3; chr19:3708337-3750813 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8458
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: TJP3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    10 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Tjp3
  • Incidental Mutations
Homozygous mutation of this gene results in viable and fertile mice with no abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034917 Ensembl Gene Model | MGI Sequence Detail 18061 C57BL/6J ±  kb
transcript ENSMUST00000045744 Ensembl | MGI Sequence Detail 3024 Not Applicable  
polypeptide ENSMUSP00000036438 Ensembl | MGI Sequence Detail 904 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    13 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 51

    Microarray probesets 5
References
more
  • Summaries
    All 34
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:58914 Itoh M, et al., Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol. 1999 Dec 13;147(6):1351-63
  • Latest
    J:182969 Capaldo CT, et al., Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation. Mol Biol Cell. 2011 May 15;22(10):1677-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory