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Abca7
Gene Detail
Symbol

Name
ID
Abca7
ATP-binding cassette, sub-family A (ABC1), member 7
MGI:1351646
Synonyms
Abc51
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr10:79996494-80015572 bp, + strand
From VEGA annotation of GRCm38

  19079 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22783  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: ABCA7
Gene Tree: Abca7

Human
homologs
ABCA7, ATP-binding cassette, sub-family A (ABC1), member 7
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10347
neXtProt AC: NX_Q8IZY2

Human Synonyms: ABCA-SSN, ABCX

Human Chr (Location): 19p13.3; chr19:1040103-1065572 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(5) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant females, but not males, have less white fat and lower total serum and HDL cholesterol levels. Males exhibit a 10% reduction in kidney size.
 
Interactions
Abca7 interacts with 35 markers (Mir34a, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process apolipoprotein A-I-mediated signaling pathway, cholesterol efflux, ...
Component apical plasma membrane, cell surface, ...
Function apolipoprotein A-I receptor activity, ATPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (116)    Tissues (116)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 22
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(9) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000032606 (Evidence)
Ensembl Gene Model ENSMUSG00000035722 (Evidence)
Entrez Gene 27403 (Evidence)
DFCI TC1641289, TC1597019
DoTS DT.97394630, DT.94207713, DT.101239596, DT.87038770, DT.525770, DT.40168840
NIA Mouse Gene Index U011734
Consensus CDS Project CCDS24004.1
International Mouse Phenotyping Consortium Status Abca7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032606 VEGA Gene Model | MGI Sequence Detail 19079 C57BL/6J ±  kb
transcript OTTMUST00000081084 VEGA | MGI Sequence Detail 6696 Not Applicable 
polypeptide OTTMUSP00000043312 VEGA | MGI Sequence Detail 2159 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(14) UniProt(5)
Polymorphisms
SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR026082 ABC transporter A, ABCA
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003545 ATP-binding cassette sub-family A member 7
References
(Earliest) J:60841 Schriml LM, et al., Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus. Genomics. 2000 Feb 15;64(1):24-31
(Latest) J:196282 Kim WS, et al., Deletion of Abca7 increases cerebral amyloid-beta accumulation in the J20 mouse model of Alzheimer's disease. J Neurosci. 2013 Mar 6;33(10):4387-94
All references(47)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory