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Prmt5
Gene Detail
 Symbol
Name
ID
Prmt5
protein arginine N-methyltransferase 5
MGI:1351645
Synonyms Jak-binding protein 1, Jbp1, Skb1
Feature Type protein coding gene
Genetic Map
Chromosome 14
27.82 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:54507187-54517525 bp, - strand
From VEGA annotation of GRCm38

  10339 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4454  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: arginine N-methyltransferase, PRMT5 type
Gene Tree: Prmt5

Human
homologs
Human Homolog PRMT5, protein arginine methyltransferase 5
NCBI Gene ID 10419
neXtProt AC  NX_O14744
Human Synonyms  HRMT1L5, IBP72, JBP1, SKB1, SKB1Hs
Human Chr (Location)  14q11.2; chr14:22920511-22929585 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(12) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display embryonic lethality before somite formation with failure of inner cell mass proliferation.
 
Interactions
Prmt5 interacts with 102 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (98 annotations)
Process chromatin modification, circadian regulation of gene expression, ...
Component cytoplasm, cytosol, ...
Function 1-hydroxy-6-methoxypyrene methyltransferase activity, 1-hydroxypyrene methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (9)    Tissues (7)    Images (8)
Theiler Stages: 24, 26, 27, 28
Assay TypeResults
RNA in situ 9
cDNA source data(205)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(207) cDNA(207)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000020079 (Evidence)
Ensembl Gene ModelENSMUSG00000023110 (Evidence)
Entrez Gene27374 (Evidence)
UniGene196585
DFCITC1572032, TC1608643, TC1687467, TC1729047
DoTSDT.101397150, DT.101738129, DT.494510, DT.96085951
NIA Mouse Gene IndexU035553
EC2.1.1.-, 2.1.1.125
Consensus CDS ProjectCCDS27091.1
International Mouse Knockout Project StatusPrmt5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020079 VEGA Gene Model | MGI Sequence Detail 10339 C57BL/6J ±  kb
transcript OTTMUST00000047756 VEGA | MGI Sequence Detail 2691 Not Applicable 
polypeptide OTTMUSP00000021696 VEGA | MGI Sequence Detail 637 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025799 Protein arginine N-methyltransferase
InterPro IPR007857 Protein arginine N-methyltransferase PRMT5
Protein Ontology PR:000013255 protein arginine N-methyltransferase 5
References (Earliest) J:58151 Pollack BP, et al., The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity. J Biol Chem. 1999 Oct 29;274(44):31531-42
(Latest) J:211407 Girardot M, et al., PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome. Nucleic Acids Res. 2014 Jan;42(1):235-48
All references(55)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory