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Prmt5 Gene Detail
Summary
  • Symbol
    Prmt5
  • Name
    protein arginine N-methyltransferase 5
  • Synonyms
    Jak-binding protein 1, Jbp1, Skb1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351645
    NCBI Gene: 27374
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:54507187-54517525 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10339 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 27.82 cM, cytoband C1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PRMT5, protein arginine methyltransferase 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRMT5, protein arginine methyltransferase 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HRMT1L5, IBP72, JBP1, SKB1, SKB1Hs
  • Links
    NCBI Gene ID: 10419
    neXtProt AC: NX_O14744
    UniProt: O14744

  • Chr Location
    14q11.2; chr14:22920511-22929585 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display embryonic lethality before somite formation with failure of inner cell mass proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020079 VEGA Gene Model | MGI Sequence Detail 10339 C57BL/6J ±  kb
    transcript OTTMUST00000047756 VEGA | MGI Sequence Detail 2691 Not Applicable  
    polypeptide OTTMUSP00000021696 VEGA | MGI Sequence Detail 637 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      116 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 208
      cDNA 208

      Microarray probesets 2
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 12
      Gene Ontology 13
      Phenotypes 20
    • Earliest
      J:58151 Pollack BP, et al., The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity. J Biol Chem. 1999 Oct 29;274(44):31531-42
    • Latest
      J:264403 Li Q, et al., Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling. J Cell Sci. 2018 Jul 25;131(14)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory