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Prmt5
Gene Detail
Symbol

Name
ID
Prmt5
protein arginine N-methyltransferase 5
MGI:1351645
Synonyms
Jak-binding protein 1, Jbp1, Skb1
Feature Type
protein coding gene
Genetic Map
Chromosome 14
27.82 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:54507187-54517525 bp, - strand
From VEGA annotation of GRCm38

  10339 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4454  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRMT5
Protein SuperFamily: arginine N-methyltransferase, PRMT5 type
Gene Tree: Prmt5

Human
homologs
PRMT5, protein arginine methyltransferase 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10419
neXtProt AC: NX_O14744

Human Synonyms: HRMT1L5, IBP72, JBP1, SKB1, SKB1Hs

Human Chr (Location): 14q11.2; chr14:22920511-22929585 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(12) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display embryonic lethality before somite formation with failure of inner cell mass proliferation.
 
Interactions
Prmt5 interacts with 102 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (9)    Tissues (7)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 9
cDNA source data(205)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prmt5 ; ZFIN prmt5    NEW 
Molecular
reagents
All nucleic(207) cDNA(207)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000020079 (Evidence)
Ensembl Gene Model ENSMUSG00000023110 (Evidence)
Entrez Gene 27374 (Evidence)
UniGene 196585
DFCI TC1572032, TC1608643, TC1687467, TC1729047
DoTS DT.101397150, DT.101738129, DT.494510, DT.96085951
NIA Mouse Gene Index U035553
EC 2.1.1.-, 2.1.1.125
Consensus CDS Project CCDS27091.1
International Mouse Phenotyping Consortium Status Prmt5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020079 VEGA Gene Model | MGI Sequence Detail 10339 C57BL/6J ±  kb
transcript OTTMUST00000047756 VEGA | MGI Sequence Detail 2691 Not Applicable 
polypeptide OTTMUSP00000021696 VEGA | MGI Sequence Detail 637 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025799 Protein arginine N-methyltransferase
InterPro IPR007857 Protein arginine N-methyltransferase PRMT5
Protein Ontology PR:000013255 protein arginine N-methyltransferase 5
References
(Earliest) J:58151 Pollack BP, et al., The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity. J Biol Chem. 1999 Oct 29;274(44):31531-42
(Latest) J:223040 Zhang T, et al., Prmt5 is a regulator of muscle stem cell expansion in adult mice. Nat Commun. 2015;6:7140
All references(61)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory