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Abcc5 Gene Detail
Summary
  • Symbol
    Abcc5
  • Name
    ATP-binding cassette, sub-family C (CFTR/MRP), member 5
  • Synonyms
    2900011L11Rik, Abcc5a, Abcc5b, Mrp5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351644
    NCBI Gene: 27416
  • Gene Overview
    MyGene.info: ABCC5
Location & Maps
more
  • Sequence Map
    Chr16:20331303-20426394 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      95092 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ABCC5, ATP binding cassette subfamily C member 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ABCC5, ATP binding cassette subfamily C member 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ABC33, EST277145, MOATC, MOAT-C, MRP5, pABC11, SMRP
  • Links
    NCBI Gene ID: 10057
    neXtProt AC: NX_O15440

  • Chr Location
    3q27; chr3:183919934-184018010 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Mice homozygous for a knock-out allele display normal cGMP transport into erythrocyte membrane vesicles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025954 VEGA Gene Model | MGI Sequence Detail 95092 C57BL/6J ±  kb
transcript OTTMUST00000064008 VEGA | MGI Sequence Detail 5811 Not Applicable  
polypeptide OTTMUSP00000031743 VEGA | MGI Sequence Detail 1436 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    719 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000003561 multidrug resistance-associated protein 5
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR017871 ABC transporter, conserved site
    IPR003439 ABC transporter-like
    IPR011527 ABC transporter type 1, transmembrane domain
    IPR030238 Multidrug resistance-associated protein 5
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 124
    cDNA 124

    Microarray probesets 11
Other
Accession IDs
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MGI:1351643, MGI:1925590, MGI:2146379
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:58835 Konig J, et al., Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochim Biophys Acta. 1999 Dec 6;1461(2):377-94
  • Latest
    J:215247 Korolnek T, et al., Control of metazoan heme homeostasis by a conserved multidrug resistance protein. Cell Metab. 2014 Jun 3;19(6):1008-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory