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Msrb1
Gene Detail
Symbol

Name
ID
Msrb1
methionine sulfoxide reductase B1
MGI:1351642
Synonyms
D17Wsu82e, SelR, Sepr, Sepx1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:24736642-24742778 bp, + strand
From VEGA annotation of GRCm38

  6137 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8455  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Msrb1

Human
homologs
Human Homolog MSRB1, methionine sulfoxide reductase B1
NCBI Gene ID 51734
neXtProt AC  NX_Q9NZV6
Human Synonyms  SELR, SELX, SepR, SEPX1
Human Chr (Location)  16p13.3; chr16:1938233-1943293 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
 
Mice homozygous for a gene trap allele exhibit oxidative stress.
 
Interactions
Msrb1 interacts with 112 markers (Mir10b, Mir17, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process actin filament polymerization, immune system process, ...
Component actin cytoskeleton, cytoplasm, ...
Function actin binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (30)    Tissues (17)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RT-PCR 6
cDNA source data(131)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(133) cDNA(132) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021061 (Evidence)
Ensembl Gene ModelENSMUSG00000075705 (Evidence)
Entrez Gene27361 (Evidence)
UniGene28212
DFCITC1575517
DoTSDT.495187
NIA Mouse Gene IndexU017650
EC1.8.4.-
PDB2KV1
Consensus CDS ProjectCCDS28495.1
International Mouse Knockout Project StatusMsrb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021061 VEGA Gene Model | MGI Sequence Detail 6137 C57BL/6J ±  kb
transcript OTTMUST00000049818 VEGA | MGI Sequence Detail 886 Not Applicable 
polypeptide OTTMUSP00000023144 VEGA | MGI Sequence Detail 116 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011057 Mss4-like
InterPro IPR002579 Peptide methionine sulphoxide reductase MrsB
Protein Ontology PR:000014663 methionine-R-sulfoxide reductase B1
References
(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:206322 Kwon TJ, et al., Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells. Hum Mol Genet. 2014 Mar 15;23(6):1591-601
All references(43)
Other
accession IDs
MGD-MRK-33975, MGI:106283

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory