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Msrb1
Gene Detail
Symbol

Name
ID
Msrb1
methionine sulfoxide reductase B1
MGI:1351642
Synonyms
D17Wsu82e, SelR, Sepr, Sepx1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:24736642-24742778 bp, + strand
From VEGA annotation of GRCm38

  6137 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8455  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MSRB1
Gene Tree: Msrb1

Human
homologs
MSRB1, methionine sulfoxide reductase B1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 51734
neXtProt AC: NX_Q9NZV6

Human Synonyms: HSPC270, SELR, SELX, SepR, SEPX1

Human Chr (Location): 16p13.3; chr16:1938233-1943293 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
 
Mice homozygous for a gene trap allele exhibit oxidative stress.
 
Interactions
Msrb1 interacts with 111 markers (Mir10b, Mir17, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process actin filament polymerization, immune system process, ...
Component actin cytoskeleton, cytoplasm, ...
Function actin binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (30)    Tissues (17)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RT-PCR 6
cDNA source data(131)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase msrb1 ; ZFIN msrb1a, msrb1b    NEW 
Molecular
reagents
All nucleic(133) cDNA(132) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021061 (Evidence)
Ensembl Gene Model ENSMUSG00000075705 (Evidence)
Entrez Gene 27361 (Evidence)
UniGene 28212
DFCI TC1575517
DoTS DT.495187
NIA Mouse Gene Index U017650
EC 1.8.4.-
PDB 2KV1
Consensus CDS Project CCDS28495.1
International Mouse Phenotyping Consortium Status Msrb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021061 VEGA Gene Model | MGI Sequence Detail 6137 C57BL/6J ±  kb
transcript OTTMUST00000049818 VEGA | MGI Sequence Detail 886 Not Applicable 
polypeptide OTTMUSP00000023144 VEGA | MGI Sequence Detail 116 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011057 Mss4-like
InterPro IPR002579 Peptide methionine sulphoxide reductase MrsB
Protein Ontology PR:000014663 methionine-R-sulfoxide reductase B1
References
(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:206322 Kwon TJ, et al., Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells. Hum Mol Genet. 2014 Mar 15;23(6):1591-601
All references(42)
Other
accession IDs
MGD-MRK-33975, MGI:106283

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory