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Abcc6
Gene Detail
 Symbol
Name
ID
Abcc6
ATP-binding cassette, sub-family C (CFTR/MRP), member 6
MGI:1351634
Synonyms DCC, Dyscalc1, Mrp6
Feature Type protein coding gene
Genetic Map
Chromosome 7
29.64 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr7:45976380-46030302 bp, - strand
From VEGA annotation of GRCm38

  53923 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55559  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Abcc6

Human
homologs
Human Homolog ABCC6, ATP-binding cassette, sub-family C (CFTR/MRP), member 6
NCBI Gene ID 368
neXtProt AC  NX_O95255
Human Synonyms  ABC34, ARA, EST349056, GACI2, MLP1, MOATE, MOAT-E, MRP6, PXE, PXE1, URG7
Human Chr (Location)  16p13.1; chr16:16149565-16223471 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human ABCC6
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(1) QTL(9) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display patchy mineralization which may include the capsule surrounding the sinuses of vibrissae, medium sized arteries, skin, retina, kidney, and interscapular brown fat. Strain differences at this locus may lead to altered susceptibility to cardiac calcinosis.
 
Human Diseases Modeled Using Mouse Abcc6 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Abcc6 interacts with 92 markers (Mir22, Mir29b-1, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process ATP catabolic process, transmembrane transport, ...
Component apical plasma membrane, integral component of membrane, ...
Function ATPase activity, ATPase activity, coupled to transmembrane movement of substances, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (123)    Tissues (111)   
Theiler Stages: 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 11
RNA in situ 106
RNase protection 6
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(22)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031288 (Evidence)
Ensembl Gene ModelENSMUSG00000030834 (Evidence)
Entrez Gene27421 (Evidence)
UniGene63514
DFCITC1587152
DoTSDT.101353347, DT.523464
NIA Mouse Gene IndexU028549
Consensus CDS ProjectCCDS21272.1
International Mouse Knockout Project StatusAbcc6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031288 VEGA Gene Model | MGI Sequence Detail 53923 C57BL/6J ±  kb
transcript OTTMUST00000077529 VEGA | MGI Sequence Detail 4974 Not Applicable 
polypeptide OTTMUSP00000041023 VEGA | MGI Sequence Detail 1498 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(13) UniProt(1)
Polymorphisms SNPs within 2kb(781 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR001140 ABC transporter, transmembrane domain
InterPro IPR011527 ABC transporter, transmembrane domain, type 1
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003562 multidrug resistance-associated protein 6
References (Earliest) J:33253 Ivandic BT, et al., A locus on chromosome 7 determines myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice. Proc Natl Acad Sci U S A. 1996 May 28;93(11):5483-8
(Latest) J:210970 Boraldi F, et al., Changes in Dermal Fibroblasts from Abcc6(-/-) Mice Are Present before and after the Onset of Ectopic Tissue Mineralization. J Invest Dermatol. 2014 Jul;134(7):1855-61
All references(69)
Disease annotation references (6)
Other
accession IDs
MGI:892987

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory