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Ip6k1 Gene Detail
Summary
  • Symbol
    Ip6k1
  • Name
    inositol hexaphosphate kinase 1
  • Synonyms
    1200016D08Rik, Ihpk1, InsP6, InsP6k1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351633
    NCBI Gene: 27399
  • Gene Overview
    MyGene.info: IP6K1
Location & Maps
more
  • Sequence Map
    Chr9:108002501-108048782 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46282 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IP6K1, inositol hexakisphosphate kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IP6K1, inositol hexakisphosphate kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IHPK1, PiUS
  • Links
    NCBI Gene ID: 9807
    neXtProt AC: NX_Q92551

  • Chr Location
    3p21.31; chr3:49724295-49786540 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56602
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: IP6K1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired glucose tolerance, decreased insulin levels, bilateral epididymal aspermia, and testicular degeneration in males.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042012 VEGA Gene Model | MGI Sequence Detail 46282 C57BL/6J ±  kb
transcript OTTMUST00000110103 VEGA | MGI Sequence Detail 4559 Not Applicable  
polypeptide OTTMUSP00000061354 VEGA | MGI Sequence Detail 433 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    99 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000009080 inositol hexakisphosphate kinase 1
  • EC
  • InterPro Domains
    IPR005522 Inositol polyphosphate kinase
Molecular
Reagents
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  • All nucleic 218
    cDNA 218

    Microarray probesets 8
Other
Accession IDs
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MGI:1914851, MGI:2143219
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:58528 Saiardi A, et al., Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Curr Biol. 1999 Nov 18;9(22):1323-6
  • Latest
    J:216770 Rao F, et al., Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16005-10

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory