Ip6k1
Gene Detail

Symbol Name ID

Ip6k1 inositol hexaphosphate kinase 1 MGI:1351633

Synonyms

1200016D08Rik, Ihpk1, InsP6

Feature Type

protein coding gene

Genetic Map

Chromosome 9

59.07 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:108002501-108048780 bp, + strand From VEGA annotation of GRCm38   46280 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; rabbit, European    (Mammalian Orthology)
Comparative Map (Mouse/Human Ip6k1 ± 2 cM)

Gene Tree: Ip6k1

Human ortholog

IP6K1 inositol hexakisphosphate kinase 1 NCBI Gene ID 9807
Human Synonyms: IHPK1, PiUS
Human Chr3:49761728-49823973 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Homozygous mutation of this gene results in impaired glucose tolerance, decreased insulin levels, bilateral epididymal aspermia, and testicular degeneration in males.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	inositol metabolic process, inositol phosphate biosynthetic process, ...
Component	cytoplasm, nucleus
Function	ATP binding, inositol-1,4,5-trisphosphate 3-kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (102)    Tissues (97)    Images (16)
Theiler Stages: 22

Assay Type	Results
RNA in situ	102

cDNA source data(217)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(217) cDNA(217)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000042012 (Evidence)
Ensembl Gene Model	ENSMUSG00000032594 (Evidence)
Entrez Gene	27399 (Evidence)
UniGene	276155
DFCI	TC1609875, TC1655812, TC1742934
DoTS	DT.101142237, DT.110616421, DT.110616487, DT.535470, DT.91365501, DT.91446469, DT.94233218, DT.94233238, DT.97396692
EC	2.7.4.21
Consensus CDS Project	CCDS23514.1
International Mouse Knockout Project Status	Ip6k1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000042012	VEGA Gene Model | MGI Sequence Detail	46280	C57BL/6J
transcript	OTTMUST00000110103	VEGA | MGI Sequence Detail	4557	Not Applicable
polypeptide	OTTMUSP00000061354	VEGA | MGI Sequence Detail	433	Not Applicable

All sequences(114) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(83 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005522	Inositol polyphosphate kinase
Protein Ontology	PR:000009080	inositol hexakisphosphate kinase 1

References

(Earliest) J:58528 Saiardi A, et al., Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Curr Biol. 1999 Nov 18;9(22):1323-6
(Latest) J:177831 Szijgyarto Z, et al., Influence of inositol pyrophosphates on cellular energy dynamics. Science. 2011 Nov 11;334(6057):802-5
All references(39)

Other accession IDs

MGI:1914851, MGI:2143219