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Sh2d3c Gene Detail
Summary
  • Symbol
    Sh2d3c
  • Name
    SH2 domain containing 3C
  • Synonyms
    Cas/HEF1-associated signal transducer, Chat, Nsp3, SH2-containing Eph receptor-binding protein 1, Shep1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351631
    NCBI Gene: 27387
  • Gene Overview
    MyGene.info: SH2D3C
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:32721055-32755007 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.09 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351631
protein coding gene Chr2:32721055-32755512 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025619
protein coding gene Chr2:31210266-31247428 (+)
A/J MGP_AJ_G0025596
protein coding gene Chr2:29874875-29911618 (+)
AKR/J MGP_AKRJ_G0025566
protein coding gene Chr2:30948423-30985620 (+)
BALB/cJ MGP_BALBcJ_G0025593
protein coding gene Chr2:29996147-30030730 (+)
C3H/HeJ MGP_C3HHeJ_G0025353
protein coding gene Chr2:30831575-30869117 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026037
protein coding gene Chr2:32147079-32183596 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023446
protein coding gene Chr2:28594859-28629700 (+)
CAST/EiJ MGP_CASTEiJ_G0024815
protein coding gene Chr2:30779781-30819038 (+)
CBA/J MGP_CBAJ_G0025331
protein coding gene Chr2:33379541-33417102 (+)
DBA/2J MGP_DBA2J_G0025464
protein coding gene Chr2:29639658-29673974 (+)
FVB/NJ MGP_FVBNJ_G0025426
protein coding gene Chr2:29526769-29561222 (+)
LP/J MGP_LPJ_G0025550
protein coding gene Chr2:31082940-31121491 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025457
protein coding gene Chr2:32999123-33035787 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026095
protein coding gene Chr2:30816855-30854011 (+)
PWK/PhJ MGP_PWKPhJ_G0024563
protein coding gene Chr2:29545477-29582008 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024363
protein coding gene Chr2:30973052-31014340 (+)
WSB/EiJ MGP_WSBEiJ_G0024884
protein coding gene Chr2:31002049-31041832 (+)



Homology
more
  • Human Ortholog
    SH2D3C, SH2 domain containing 3C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SH2D3C, SH2 domain containing 3C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHAT, NSP3, PRO34088, SHEP1
  • Links
    NCBI Gene ID: 10044
    neXtProt AC: NX_Q8N5H7
    UniProt: Q8N5H7

  • Chr Location
    9q34.11; chr9:127738317-127778769 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 69145
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SH2D3C
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality with absence of gastric milk. Surviving mice exhibit abnormal olfactory bulb innervation, fewer gonadotrophin positive cells in the hypothalamus, and decreased testes size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 27387 NCBI Gene Model | MGI Sequence Detail 33953 C57BL/6J ±  kb
transcript NR_045535 RefSeq | MGI Sequence Detail 3563 C57BL/6  
polypeptide Q9QZS8 UniProt | EBI | MGI Sequence Detail 854 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014816 SH2 domain-containing protein 3C
  • InterPro Domains
    IPR036964 Ras guanine-nucleotide exchange factor catalytic domain superfamily
    IPR023578 Ras guanine nucleotide exchange factor domain superfamily
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR000980 SH2 domain
    IPR036860 SH2 domain superfamily
Molecular
Reagents
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  • All nucleic 10
    cDNA 10

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:58260 Dodelet VC, et al., A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A. J Biol Chem. 1999 Nov 5;274(45):31941-6
  • Latest
    J:246144 Herbin O, et al., Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1791-801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory