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Sergef Gene Detail
Summary
  • Symbol
    Sergef
  • Name
    secretion regulating guanine nucleotide exchange factor
  • Synonyms
    DelGEF, Gef, Gnefr
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351630
    NCBI Gene: 27414
Location & Maps
more
  • Sequence Map
    Chr7:46443154-46639807 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      196654 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 30.20 cM, cytoband B3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SERGEF, secretion regulating guanine nucleotide exchange factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SERGEF, secretion regulating guanine nucleotide exchange factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DELGEF, Gnefr
  • Links
    NCBI Gene ID: 26297
    neXtProt AC: NX_Q9UGK8

  • Chr Location
    11p14.3; chr11:17788048-18013162 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    9
  • Gene trapped
    7
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025417 VEGA Gene Model | MGI Sequence Detail 196654 C57BL/6J ±  kb
transcript OTTMUST00000062581 VEGA | MGI Sequence Detail 1465 Not Applicable  
polypeptide OTTMUSP00000030870 VEGA | MGI Sequence Detail 464 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1716 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000014668 secretion-regulating guanine nucleotide exchange factor
  • InterPro Domains
    IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
    IPR000408 Regulator of chromosome condensation, RCC1
    IPR027048 Secretion-regulating guanine nucleotide exchange factor
Molecular
Reagents
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  • All nucleic 21
    cDNA 21

    Microarray probesets 3
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:58143 Uhlmann J, et al., DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness. FEBS Lett. 1999 Oct 22;460(1):153-60
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory