About   Help   FAQ
Pign
Gene Detail
 Symbol
Name
ID
Pign
phosphatidylinositol glycan anchor biosynthesis, class N
MGI:1351629
Feature Type protein coding gene
Genetic Map
Chromosome 1
49.63 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:105518422-105659008 bp, - strand
From Ensembl annotation of GRCm38

  140587 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6330  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pign

Human
homologs
Human Homolog PIGN, phosphatidylinositol glycan anchor biosynthesis, class N
NCBI Gene ID 23556
neXtProt AC  NX_O95427
Human Synonyms  MCAHS, MCAHS1, MCD4, MDC4, PIG-N
Human Chr (Location)  18q21.33; chr18:62044224-62187056 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PIGN
Alleles
and
phenotypes
All alleles(3) : Targeted(1) Gene trapped(1) Chemically induced(1)
 
Mice homozygous for an ENU-induced allele exhibit abnormal gastrulation, forebrain hypoplasia, coloboma, and microphthalmia.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process GPI anchor biosynthetic process, metabolic process
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function catalytic activity, phosphotransferase activity, for other substituted phosphate groups, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (137)    Tissues (123)    Images (13)
Theiler Stages: 11, 13, 19, 22, 23, 28
Assay TypeResults
RNA in situ 137
cDNA source data(59)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(60) cDNA(60)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000056536 (Evidence)
Entrez Gene27392 (Evidence)
UniGene268911
DFCITC1582595, TC1596470, TC1695945
DoTSDT.110905960, DT.40167981, DT.485575, DT.60103205, DT.97412182
NIA Mouse Gene IndexU021654
EC2.-.-.-
Consensus CDS ProjectCCDS15205.1
International Mouse Knockout Project StatusPign
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056536 Ensembl Gene Model | MGI Sequence Detail 140587 C57BL/6J ±  kb
transcript ENSMUST00000070699 Ensembl | MGI Sequence Detail 6528 Not Applicable 
polypeptide ENSMUSP00000069969 Ensembl | MGI Sequence Detail 931 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(12) UniProt(2)
Polymorphisms SNPs within 2kb(899 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR007070 GPI ethanolamine phosphate transferase 1
InterPro IPR017852 GPI ethanolamine phosphate transferase 1, C-terminal
InterPro IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
Protein Ontology PR:000012701 GPI ethanolamine phosphate transferase 1
References (Earliest) J:50570 Hong Y, et al., Pig-n, a mammalian homologue of yeast Mcd4p, is involved in transferring phosphoethanol-amine to the first mannose of the glycosylphosphatidylinositol. J Biol Chem. 1999 Dec 3;274(49):35099-106
(Latest) J:187360 McKean DM, et al., Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly. Biol Open. 2012;1(9):874-883
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory