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Pign
Gene Detail
Symbol

Name
ID
Pign
phosphatidylinositol glycan anchor biosynthesis, class N
MGI:1351629
Feature Type
protein coding gene
Genetic Map
Chromosome 1
49.63 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:105518426-105663677 bp, - strand
From VEGA annotation of GRCm38

  145252 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6330  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pign

Human
homologs
Human Homolog PIGN, phosphatidylinositol glycan anchor biosynthesis, class N
NCBI Gene ID 23556
neXtProt AC  NX_O95427
Human Synonyms  MCAHS, MCAHS1, MCD4, MDC4, PIG-N
Human Chr (Location)  18q21.33; chr18:62044224-62187056 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PIGN
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Gene trapped(3) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced allele exhibit abnormal gastrulation, forebrain hypoplasia, coloboma, and microphthalmia.
 
Interactions
Pign interacts with 434 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process GPI anchor biosynthetic process, metabolic process
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function catalytic activity, Kdo transferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (137)    Tissues (123)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 137
cDNA source data(59)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(60) cDNA(60)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000048961 (Evidence)
Ensembl Gene ModelENSMUSG00000056536 (Evidence)
Entrez Gene27392 (Evidence)
UniGene268911
DFCITC1582595, TC1596470, TC1695945
DoTSDT.110905960, DT.40167981, DT.485575, DT.60103205, DT.97412182
NIA Mouse Gene IndexU021654
EC2.-.-.-
Consensus CDS ProjectCCDS15205.1
International Mouse Knockout Project StatusPign
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048961 VEGA Gene Model | MGI Sequence Detail 145252 C57BL/6J ±  kb
transcript OTTMUST00000125080 VEGA | MGI Sequence Detail 6759 Not Applicable 
polypeptide OTTMUSP00000067902 VEGA | MGI Sequence Detail 931 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(899 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR007070 GPI ethanolamine phosphate transferase 1
InterPro IPR017852 GPI ethanolamine phosphate transferase 1, C-terminal
InterPro IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
Protein Ontology PR:000012701 GPI ethanolamine phosphate transferase 1
References
(Earliest) J:50570 Hong Y, et al., Pig-n, a mammalian homologue of yeast Mcd4p, is involved in transferring phosphoethanol-amine to the first mannose of the glycosylphosphatidylinositol. J Biol Chem. 1999 Dec 3;274(49):35099-106
(Latest) J:187360 McKean DM, et al., Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly. Biol Open. 2012;1(9):874-883
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory