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Pign
Gene Detail
Symbol

Name
ID
Pign
phosphatidylinositol glycan anchor biosynthesis, class N
MGI:1351629
Feature Type
protein coding gene
Genetic Map
Chromosome 1
49.63 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:105518426-105663677 bp, - strand
From VEGA annotation of GRCm38

  145252 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6330  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PIGN
Gene Tree: Pign

Human
homologs
PIGN, phosphatidylinositol glycan anchor biosynthesis, class N
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23556
neXtProt AC: NX_O95427

Human Synonyms: MCAHS, MCAHS1, MCD4, MDC4, PIG-N

Human Chr (Location): 18q21.33; chr18:62044224-62187118 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PIGN

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Gene trapped(3) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for an ENU-induced allele exhibit abnormal gastrulation, forebrain hypoplasia, coloboma, and microphthalmia.
 
Interactions
Pign interacts with 433 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process GPI anchor biosynthetic process, metabolic process
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function catalytic activity, Kdo transferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (137)    Tissues (123)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 137
cDNA source data(59)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pign    NEW 
Molecular
reagents
All nucleic(60) cDNA(60)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000048961 (Evidence)
Ensembl Gene Model ENSMUSG00000056536 (Evidence)
Entrez Gene 27392 (Evidence)
UniGene 268911
DFCI TC1695945, TC1596470, TC1582595
DoTS DT.97412182, DT.60103205, DT.485575, DT.40167981, DT.110905960
NIA Mouse Gene Index U021654
EC 2.-.-.-
Consensus CDS Project CCDS15205.1
International Mouse Phenotyping Consortium Status Pign
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048961 VEGA Gene Model | MGI Sequence Detail 145252 C57BL/6J ±  kb
transcript OTTMUST00000125080 VEGA | MGI Sequence Detail 6759 Not Applicable 
polypeptide OTTMUSP00000067902 VEGA | MGI Sequence Detail 931 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(12) UniProt(5)
Polymorphisms
SNPs within 2kb(899 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR007070 GPI ethanolamine phosphate transferase 1
InterPro IPR017852 GPI ethanolamine phosphate transferase 1, C-terminal
InterPro IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
Protein Ontology PR:000012701 GPI ethanolamine phosphate transferase 1
References
(Earliest) J:50570 Hong Y, et al., Pig-n, a mammalian homologue of yeast Mcd4p, is involved in transferring phosphoethanol-amine to the first mannose of the glycosylphosphatidylinositol. J Biol Chem. 1999 Dec 3;274(49):35099-106
(Latest) J:187360 McKean DM, et al., Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly. Biol Open. 2012;1(9):874-883
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory