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Pdhx Gene Detail
Summary
  • Symbol
    Pdhx
  • Name
    pyruvate dehydrogenase complex, component X
  • Synonyms
    Pdx1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351627
    NCBI Gene: 27402
  • Gene Overview
    MyGene.info: PDHX
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:103021075-103073513 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 54.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    384 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351627
protein coding gene Chr2:103021055-103073513 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026200
protein coding gene Chr2:104971575-105027773 (-)
A/J MGP_AJ_G0026161
protein coding gene Chr2:100653736-100707839 (-)
AKR/J MGP_AKRJ_G0026142
protein coding gene Chr2:103378117-103430384 (-)
BALB/cJ MGP_BALBcJ_G0026170
protein coding gene Chr2:100934246-100987214 (-)
C3H/HeJ MGP_C3HHeJ_G0025921
protein coding gene Chr2:103743510-103796537 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026621
protein coding gene Chr2:108522506-108575848 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024012
protein coding gene Chr2:96315061-96373975 (-)
CAST/EiJ MGP_CASTEiJ_G0025386
protein coding gene Chr2:104184974-104242026 (-)
CBA/J MGP_CBAJ_G0025899
protein coding gene Chr2:112225515-112279875 (-)
DBA/2J MGP_DBA2J_G0026035
protein coding gene Chr2:100219135-100272245 (-)
FVB/NJ MGP_FVBNJ_G0025998
protein coding gene Chr2:99218052-99272910 (-)
LP/J MGP_LPJ_G0026139
protein coding gene Chr2:105119732-105174561 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026024
protein coding gene Chr2:116158077-116210357 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026675
protein coding gene Chr2:103593989-103646274 (-)
PWK/PhJ MGP_PWKPhJ_G0025121
protein coding gene Chr2:99715543-99768403 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024922
protein coding gene Chr2:102814936-102868714 (-)
WSB/EiJ MGP_WSBEiJ_G0025453
protein coding gene Chr2:104298144-104351115 (-)



Homology
more
  • Human Ortholog
    PDHX, pyruvate dehydrogenase complex component X
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PDHX, pyruvate dehydrogenase complex component X
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DLDBP, E3BP, OPDX, PDHXD, PDX1, proX
  • Links
    NCBI Gene ID: 8050
    neXtProt AC: NX_O00330
    UniProt: O00330

  • Chr Location
    11p13; chr11:34915829-34996128 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PDHX associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000010914 Ensembl Gene Model | MGI Sequence Detail 52439 C57BL/6J ±  kb
transcript ENSMUST00000011058 Ensembl | MGI Sequence Detail 2506 Not Applicable  
polypeptide ENSMUSP00000011058 Ensembl | MGI Sequence Detail 501 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012496 pyruvate dehydrogenase protein X component, mitochondrial
  • InterPro Domains
    IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
    IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
    IPR000089 Biotin/lipoyl attachment
    IPR023213 Chloramphenicol acetyltransferase-like domain superfamily
    IPR036625 E3-binding domain superfamily
    IPR004167 Peripheral subunit-binding domain
    IPR011053 Single hybrid motif
Molecular
Reagents
less
  • All nucleic 52
    cDNA 52

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138985
References
more
  • Summaries
    All 33
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory