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Pdhx
Gene Detail
Symbol

Name
ID
Pdhx
pyruvate dehydrogenase complex, component X
MGI:1351627
Synonyms
Pdx1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
54.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:103021075-103073513 bp, - strand
From VEGA annotation of GRCm38

  52439 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55757  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: dihydrolipoamide acetyltransferase
Gene Tree: Pdhx

Human
homologs
Human Homolog PDHX, pyruvate dehydrogenase complex, component X
NCBI Gene ID 8050
neXtProt AC  NX_O00330
Human Synonyms  DLDBP, E3BP, OPDX, PDX1, proX
Human Chr (Location)  11P13; chr11:34916130-34996128 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PDHX
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pdhx interacts with 177 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process metabolic process
Component mitochondrion
Function transferase activity, transferring acyl groups
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (113)    Tissues (112)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 102
Northern blot 11
cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) cDNA(51)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000014841 (Evidence)
Ensembl Gene ModelENSMUSG00000010914 (Evidence)
Entrez Gene27402 (Evidence)
UniGene315011
DFCITC1578691, TC1625451
DoTSDT.101240519, DT.97364081
NIA Mouse Gene IndexU023082
Consensus CDS ProjectCCDS16473.1
International Mouse Knockout Project StatusPdhx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014841 VEGA Gene Model | MGI Sequence Detail 52439 C57BL/6J ±  kb
transcript OTTMUST00000035238 VEGA | MGI Sequence Detail 2506 Not Applicable 
polypeptide OTTMUSP00000015743 VEGA | MGI Sequence Detail 501 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(387 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
InterPro IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
InterPro IPR000089 Biotin/lipoyl attachment
InterPro IPR023213 Chloramphenicol acetyltransferase-like domain
InterPro IPR004167 E3 binding
InterPro IPR011053 Single hybrid motif
Protein Ontology PR:000012496 pyruvate dehydrogenase protein X component, mitochondrial
References
(Earliest) J:58552 Gawin B, et al., A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1. Genome Res. 1999 Nov;9(11):1074-86
(Latest) J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23
All references(28)
Other
accession IDs
MGI:2138985

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory