Pdhx
Gene Detail

Symbol Name ID

Pdhx pyruvate dehydrogenase complex, component X MGI:1351627

Synonyms

Pdx1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

54.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:103021075-103073513 bp, - strand From VEGA annotation of GRCm38   52439 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55757  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: dihydrolipoamide acetyltransferase
Gene Tree: Pdhx

Human homologs

Human Homolog		PDHX, pyruvate dehydrogenase complex, component X
NCBI Gene ID		8050
neXtProt AC		NX_O00330
Human Synonyms		DLDBP, E3BP, OPDX, PDX1, proX
Human Chr (Location)		11P13; chr11:34937677-35017675 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PDHX

Alleles and phenotypes

All alleles(2) : Targeted(2)

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	metabolic process
Component	mitochondrion
Function	transferase activity, transferase activity, transferring acyl groups

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (113)    Tissues (112)    Images (8)
Theiler Stages: 16, 18, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	102
Northern blot	11

cDNA source data(54)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(54) cDNA(54)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000014841 (Evidence)
Ensembl Gene Model	ENSMUSG00000010914 (Evidence)
Entrez Gene	27402 (Evidence)
UniGene	315011
DFCI	TC1578691, TC1625451
DoTS	DT.101240519, DT.97364081
NIA Mouse Gene Index	U023082
Consensus CDS Project	CCDS16473.1
International Mouse Knockout Project Status	Pdhx

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014841	VEGA Gene Model | MGI Sequence Detail	52439	C57BL/6J
transcript	OTTMUST00000035238	VEGA | MGI Sequence Detail	2506	Not Applicable
polypeptide	OTTMUSP00000015743	VEGA | MGI Sequence Detail	501	Not Applicable

All sequences(39) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(358 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001078	2-oxoacid dehydrogenase acyltransferase, catalytic domain
InterPro	IPR003016	2-oxo acid dehydrogenase, lipoyl-binding site
InterPro	IPR000089	Biotin/lipoyl attachment
InterPro	IPR023213	Chloramphenicol acetyltransferase-like domain
InterPro	IPR004167	E3 binding
InterPro	IPR011053	Single hybrid motif
Protein Ontology	PR:000012496	pyruvate dehydrogenase protein X component, mitochondrial

References

(Earliest) J:58552 Gawin B, et al., A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1. Genome Res. 1999 Nov;9(11):1074-86
(Latest) J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23
All references(29)

Other accession IDs

MGI:2138985