Abcb11
Gene Detail

Symbol Name ID

Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 MGI:1351619

Synonyms

ABC16, Bsep, Lith1, PFIC2, PGY4, sister of P-glycoprotein

Feature Type

protein coding gene

Genetic Map

Chromosome 2

39.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr2:69238282-69342614 bp, - strand From VEGA annotation of GRCm38   104333 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74509  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: multidrug resistance protein
Gene Tree: Abcb11

Human homologs

Human Homolog		ABCB11, ATP-binding cassette, sub-family B (MDR/TAP), member 11
NCBI Gene ID		8647
neXtProt AC		NX_O95342
Human Synonyms		ABC16, BRIC2, BSEP, PFIC2, PFIC-2, PGY4, SPGP
Human Chr (Location)		2q24; chr2:169779449-169887833 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ABCB11

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for targeted mutations that inactivate the gene display intrahepatic cholestasis.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	canalicular bile acid transport, transmembrane transport, ...
Component	apical part of cell, apical plasma membrane, ...
Function	ATPase activity, ATPase activity, coupled to transmembrane movement of substances, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (103)    Tissues (96)   
Theiler Stages: 22, 24, 28

Assay Type	Results
RNA in situ	94
Northern blot	9

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(1) cDNA(13) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000012983 (Evidence)
Ensembl Gene Model	ENSMUSG00000027048 (Evidence)
Entrez Gene	27413 (Evidence)
UniGene	439855
DFCI	TC1585430
DoTS	DT.101259622, DT.488426
NIA Mouse Gene Index	U022708
Consensus CDS Project	CCDS16090.1
International Mouse Knockout Project Status	Abcb11

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012983	VEGA Gene Model | MGI Sequence Detail	104333	C57BL/6J
transcript	OTTMUST00000031268	VEGA | MGI Sequence Detail	4893	Not Applicable
polypeptide	OTTMUSP00000013989	VEGA | MGI Sequence Detail	1321	Not Applicable

All sequences(35) RefSeq(2) UniProt(3)

Polymorphisms

PCR(2) : SNPs(945 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR017871	ABC transporter, conserved site
InterPro	IPR017940	ABC transporter, integral membrane type 1
InterPro	IPR003439	ABC transporter-like
InterPro	IPR001140	ABC transporter, transmembrane domain
InterPro	IPR011527	ABC transporter, transmembrane domain, type 1
Protein Ontology	PR:000003549	bile salt export pump

References

(Earliest) J:54870 Lammert F, et al., Genetic mapping of Hepatocanalicular transporters establishes sister-p-glycoprotein (spgp) as a candidate for the major gallstone gene (Lith1). Hepatology. 1997;26:358A (Abstr.)
(Latest) J:188866 Zhang Y, et al., Abcb11 deficiency induces cholestasis coupled to impaired beta-fatty acid oxidation in mice. J Biol Chem. 2012 Jul 13;287(29):24784-94
All references(49)

Other accession IDs

MGI:1341119