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Abcb11
Gene Detail
Symbol

Name
ID
Abcb11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
MGI:1351619
Synonyms
ABC16, Bsep, Lith1, PFIC2, PGY4, sister of P-glycoprotein
Feature Type
protein coding gene
Genetic Map
Chromosome 2
39.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr2:69238282-69342614 bp, - strand
From VEGA annotation of GRCm38

  104333 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74509  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ABCB11
Gene Tree: Abcb11

Human
homologs
ABCB11, ATP-binding cassette, sub-family B (MDR/TAP), member 11
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8647
neXtProt AC: NX_O95342

Human Synonyms: ABC16, BRIC2, BSEP, PFIC2, PFIC-2, PGY4, SPGP

Human Chr (Location): 2q24; chr2:168922802-169034890 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human ABCB11

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted mutations that inactivate the gene display intrahepatic cholestasis.
 
Phenotype Images(1)
Interactions
Abcb11 interacts with 144 markers (Mir10b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (103)    Tissues (97)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 9
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(13) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000012983 (Evidence)
Ensembl Gene Model ENSMUSG00000027048 (Evidence)
Entrez Gene 27413 (Evidence)
UniGene 439855
DFCI TC1585430
DoTS DT.101259622, DT.488426
NIA Mouse Gene Index U022708
Consensus CDS Project CCDS16090.1
International Mouse Phenotyping Consortium Status Abcb11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012983 VEGA Gene Model | MGI Sequence Detail 104333 C57BL/6J ±  kb
transcript OTTMUST00000031268 VEGA | MGI Sequence Detail 4893 Not Applicable 
polypeptide OTTMUSP00000013989 VEGA | MGI Sequence Detail 1321 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(6) UniProt(3)
Polymorphisms
PCR(2) : SNPs within 2kb(1092 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR011527 ABC transporter, transmembrane domain, type 1
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003549 bile salt export pump
References
(Earliest) J:54870 Lammert F, et al., Genetic mapping of Hepatocanalicular transporters establishes sister-p-glycoprotein (spgp) as a candidate for the major gallstone gene (Lith1). Hepatology. 1997;26:358A (Abstr.)
(Latest) J:215076 Homolya L, et al., LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes. PLoS One. 2014;9(3):e91921
All references(56)
Other
accession IDs
MGI:1341119

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory