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Abcb11 Gene Detail
Summary
  • Symbol
    Abcb11
  • Name
    ATP-binding cassette, sub-family B (MDR/TAP), member 11
  • Synonyms
    ABC16, Bsep, Lith1, PFIC2, PGY4, sister of P-glycoprotein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351619
    NCBI Gene: 27413
  • Gene Overview
    MyGene.info: ABCB11
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:69238282-69342616 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 39.69 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1007 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351619
protein coding gene Chr2:69238282-69342843 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025797
protein coding gene Chr2:69175014-69296645 (-)
A/J MGP_AJ_G0025774
protein coding gene Chr2:66514726-66626839 (-)
AKR/J MGP_AKRJ_G0025743
protein coding gene Chr2:68312934-68424278 (-)
BALB/cJ MGP_BALBcJ_G0025769
protein coding gene Chr2:66692858-66792715 (-)
C3H/HeJ MGP_C3HHeJ_G0025529
protein coding gene Chr2:68544216-68655588 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026216
protein coding gene Chr2:71276197-71388128 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023619
protein coding gene Chr2:63753376-63850734 (-)
CAST/EiJ MGP_CASTEiJ_G0024993
protein coding gene Chr2:68641788-68760019 (-)
CBA/J MGP_CBAJ_G0025509
protein coding gene Chr2:73876806-73996314 (-)
DBA/2J MGP_DBA2J_G0025640
protein coding gene Chr2:66156692-66266675 (-)
FVB/NJ MGP_FVBNJ_G0025603
protein coding gene Chr2:65533471-65637732 (-)
LP/J MGP_LPJ_G0025729
protein coding gene Chr2:69036698-69145367 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025632
protein coding gene Chr2:75932013-76067922 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026273
protein coding gene Chr2:68392120-68508725 (-)
PWK/PhJ MGP_PWKPhJ_G0024734
protein coding gene Chr2:65987359-66095356 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024541
protein coding gene Chr2:68628967-68734615 (-)
WSB/EiJ MGP_WSBEiJ_G0025061
protein coding gene Chr2:68820341-68936692 (-)



Homology
more
  • Human Ortholog
    ABCB11, ATP binding cassette subfamily B member 11
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ABCB11, ATP binding cassette subfamily B member 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABC16, BRIC2, BSEP, PFIC2, PFIC-2, PGY4, SPGP
  • Links
    NCBI Gene ID: 8647
    neXtProt AC: NX_O95342
    UniProt: O95342

  • Chr Location
    2q31.1; chr2:168915468-169031396 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 74509
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ABCB11
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene display intrahepatic cholestasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027048 Ensembl Gene Model | MGI Sequence Detail 104335 C57BL/6J ±  kb
    transcript ENSMUST00000102710 Ensembl | MGI Sequence Detail 4893 Not Applicable  
    polypeptide ENSMUSP00000099771 Ensembl | MGI Sequence Detail 1321 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 13
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1341119
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 23
    • Earliest
      J:54870 Lammert F, et al., Genetic mapping of Hepatocanalicular transporters establishes sister-p-glycoprotein (spgp) as a candidate for the major gallstone gene (Lith1). Hepatology. 1997;26:358A (Abstr.)
    • Latest
      J:262945 Kim KH, et al., Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis. Endocrinology. 2018 Jun 1;159(6):2435-2446

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory