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Abcb11 Gene Detail
Summary
  • Symbol
    Abcb11
  • Name
    ATP-binding cassette, sub-family B member 11
  • Synonyms
    ABC16, Bsep, Lith1, PFIC2, PGY4, sister of P-glycoprotein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351619
    NCBI Gene: 27413
  • Alliance
  • Transcription Start Sites
    3 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:69068626-69172958 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 39.69 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1007 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351619
protein coding gene Chr2:69068626-69172960 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025797
protein coding gene Chr2:69175014-69296645 (-)
A/J MGP_AJ_G0025774
protein coding gene Chr2:66514726-66626839 (-)
AKR/J MGP_AKRJ_G0025743
protein coding gene Chr2:68312934-68424278 (-)
BALB/cJ MGP_BALBcJ_G0025769
protein coding gene Chr2:66692858-66792715 (-)
C3H/HeJ MGP_C3HHeJ_G0025529
protein coding gene Chr2:68544216-68655588 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026216
protein coding gene Chr2:71276197-71388128 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023619
protein coding gene Chr2:63753376-63850734 (-)
CAST/EiJ MGP_CASTEiJ_G0024993
protein coding gene Chr2:68641788-68760019 (-)
CBA/J MGP_CBAJ_G0025509
protein coding gene Chr2:73876806-73996314 (-)
DBA/2J MGP_DBA2J_G0025640
protein coding gene Chr2:66156692-66266675 (-)
FVB/NJ MGP_FVBNJ_G0025603
protein coding gene Chr2:65533471-65637732 (-)
LP/J MGP_LPJ_G0025729
protein coding gene Chr2:69036698-69145367 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025632
protein coding gene Chr2:75932013-76067922 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026273
protein coding gene Chr2:68392120-68508725 (-)
PWK/PhJ MGP_PWKPhJ_G0024734
protein coding gene Chr2:65987359-66095356 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024541
protein coding gene Chr2:68628967-68734615 (-)
WSB/EiJ MGP_WSBEiJ_G0025061
protein coding gene Chr2:68820341-68936692 (-)



Homology
more
  • Human Ortholog
    ABCB11, ATP binding cassette subfamily B member 11
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCB11, ATP binding cassette subfamily B member 11
  • Synonyms
    ABC16, BRIC2, BSEP, PFIC2, PFIC-2, PGY4, SPGP
  • Links
    NCBI Gene ID: 8647
    neXtProt AC: NX_O95342
    UniProt: O95342

  • Chr Location
    2q31.1; chr2:168915390-169031324 (-)  GRCh38

Human Diseases
more
  • Diseases
    4 with human ABCB11 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene display intrahepatic cholestasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027048 Ensembl Gene Model | MGI Sequence Detail 104333 C57BL/6J ±  kb
    transcript ENSMUST00000102710 Ensembl | MGI Sequence Detail 4893 Not Applicable  
    polypeptide ENSMUSP00000099771 Ensembl | MGI Sequence Detail 1321 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 2
      cDNA 13
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1341119
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 4
      Gene Ontology 16
      Phenotypes 31
    • Earliest
      J:54870 Lammert F, et al., Genetic mapping of Hepatocanalicular transporters establishes sister-p-glycoprotein (spgp) as a candidate for the major gallstone gene (Lith1). Hepatology. 1997;26:358A (Abstr.)
    • Latest
      J:340414 Keller MP, et al., An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets. Diabetes. 2023;:db230215

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory