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Abcb11
Gene Detail
Symbol

Name
ID
Abcb11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
MGI:1351619
Synonyms
ABC16, Bsep, Lith1, PFIC2, PGY4, sister of P-glycoprotein
Feature Type
protein coding gene
Genetic Map
Chromosome 2
39.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr2:69238282-69342614 bp, - strand
From VEGA annotation of GRCm38

  104333 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74509  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Abcb11

Human
homologs
Human Homolog ABCB11, ATP-binding cassette, sub-family B (MDR/TAP), member 11
NCBI Gene ID 8647
neXtProt AC  NX_O95342
Human Synonyms  ABC16, BRIC2, BSEP, PFIC2, PFIC-2, PGY4, SPGP
Human Chr (Location)  2q24; chr2:168922826-169031323 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human ABCB11
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted mutations that inactivate the gene display intrahepatic cholestasis.
 
Phenotype Images(1)
Interactions
Abcb11 interacts with 144 markers (Mir10b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (103)    Tissues (97)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 9
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(13) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000012983 (Evidence)
Ensembl Gene ModelENSMUSG00000027048 (Evidence)
Entrez Gene27413 (Evidence)
UniGene439855
DFCITC1585430
DoTSDT.101259622, DT.488426
NIA Mouse Gene IndexU022708
Consensus CDS ProjectCCDS16090.1
International Mouse Knockout Project StatusAbcb11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012983 VEGA Gene Model | MGI Sequence Detail 104333 C57BL/6J ±  kb
transcript OTTMUST00000031268 VEGA | MGI Sequence Detail 4893 Not Applicable 
polypeptide OTTMUSP00000013989 VEGA | MGI Sequence Detail 1321 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(6) UniProt(5)
Polymorphisms
PCR(2) : SNPs within 2kb(1092 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR001140 ABC transporter, transmembrane domain
InterPro IPR011527 ABC transporter, transmembrane domain, type 1
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003549 bile salt export pump
References
(Earliest) J:54870 Lammert F, et al., Genetic mapping of Hepatocanalicular transporters establishes sister-p-glycoprotein (spgp) as a candidate for the major gallstone gene (Lith1). Hepatology. 1997;26:358A (Abstr.)
(Latest) J:205077 Wang R, et al., Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 15;305(4):G286-94
All references(56)
Other
accession IDs
MGI:1341119

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory