About   Help   FAQ
Exoc6
Gene Detail
Symbol

Name
ID
Exoc6
exocyst complex component 6
MGI:1351611
Synonyms
4833405E05Rik, hbd, msec15, Sec15, Sec15l1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
32.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr19:37550418-37683245 bp, + strand
From Ensembl annotation of GRCm38

  132828 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41305  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EXOC6
Protein SuperFamily: exocyst complex, component Sec15
Gene Tree: Exoc6

Human
homologs
EXOC6, exocyst complex component 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 54536
neXtProt AC: NX_Q8TAG9

Human Synonyms: EXOC6A, SEC15, SEC15L, SEC15L1, SEC15L3, Sec15p

Human Chr (Location): 10q23.33; chr10:92834713-93059494 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a spontaneous mutation exhibit severe microcytic anemia, erythrocyte hyperchromia, and markedly increased levels of red cell protoporphyrin.
 
Interactions
Exoc6 interacts with 105 markers (Mir7-2, Mir7b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process erythrocyte differentiation, exocytosis, ...
Component exocyst
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (128)    Tissues (13)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 128
cDNA source data(48)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase exoc6    NEW 
Molecular
reagents
All nucleic(50) Genomic(2) cDNA(48)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000053799 (Evidence)
Entrez Gene 107371 (Evidence)
UniGene 24865
DFCI TC1602105, TC1580956, TC1587078
DoTS DT.101725878, DT.97375083, DT.482150
NIA Mouse Gene Index U019415
Consensus CDS Project CCDS29779.1
International Mouse Phenotyping Consortium Status Exoc6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053799 Ensembl Gene Model | MGI Sequence Detail 132828 C57BL/6J ±  kb
transcript ENSMUST00000066439 Ensembl | MGI Sequence Detail 2729 Not Applicable 
polypeptide ENSMUSP00000064332 Ensembl | MGI Sequence Detail 804 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(6) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(1225 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007225 Exocyst complex subunit Sec15-like
Protein Ontology PR:000007253 exocyst complex component 6
References
(Earliest) J:5208 Scheufler H, [An additional house mouse mutant with anemia (hemoglobin deficiency)]. Z Versuchstierkd. 1969;11(5):348-53
(Latest) J:195311 Chiba S, et al., NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15. EMBO J. 2013 Mar 20;32(6):874-85
All references(44)
Other
accession IDs
MGD-MRK-10640, MGI:2147727, MGI:96028

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory