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Exoc6
Gene Detail
Symbol

Name
ID
Exoc6
exocyst complex component 6
MGI:1351611
Synonyms
4833405E05Rik, hbd, msec15, Sec15, Sec15l1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
32.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr19:37550418-37683245 bp, + strand
From Ensembl annotation of GRCm38

  132828 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41305  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: exocyst complex, component Sec15
Gene Tree: Exoc6

Human
homologs
Human Homolog EXOC6, exocyst complex component 6
NCBI Gene ID 54536
neXtProt AC  NX_Q8TAG9
Human Synonyms  EXOC6A, SEC15, SEC15L, SEC15L1, SEC15L3, Sec15p
Human Chr (Location)  10q23.33; chr10:92826831-93059494 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a spontaneous mutation exhibit severe microcytic anemia, erythrocyte hyperchromia, and markedly increased levels of red cell protoporphyrin.
 
Interactions
Exoc6 interacts with 105 markers (Mir7-2, Mir7b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process erythrocyte differentiation, exocytosis, ...
Component exocyst
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (128)    Tissues (13)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 128
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(50) Genomic(2) cDNA(48)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000053799 (Evidence)
Entrez Gene107371 (Evidence)
UniGene24865
DFCITC1580956, TC1587078, TC1602105
DoTSDT.101725878, DT.482150, DT.97375083
NIA Mouse Gene IndexU019415
Consensus CDS ProjectCCDS29779.1
International Mouse Knockout Project StatusExoc6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053799 Ensembl Gene Model | MGI Sequence Detail 132828 C57BL/6J ±  kb
transcript ENSMUST00000066439 Ensembl | MGI Sequence Detail 2729 Not Applicable 
polypeptide ENSMUSP00000064332 Ensembl | MGI Sequence Detail 804 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(1225 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007225 Exocyst complex subunit Sec15-like
Protein Ontology PR:000007253 exocyst complex component 6
References
(Earliest) J:5208 Scheufler H, [An additional house mouse mutant with anemia (hemoglobin deficiency)]. Z Versuchstierkd. 1969;11(5):348-53
(Latest) J:195311 Chiba S, et al., NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15. EMBO J. 2013 Mar 20;32(6):874-85
All references(45)
Other
accession IDs
MGD-MRK-10640, MGI:2147727, MGI:96028

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory