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Exoc6 Gene Detail
Summary
  • Symbol
    Exoc6
  • Name
    exocyst complex component 6
  • Synonyms
    4833405E05Rik, hbd, msec15, Sec15, Sec15l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351611
    NCBI Gene: 107371
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:37550418-37683245 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      132828 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 32.32 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    EXOC6, exocyst complex component 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EXOC6, exocyst complex component 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EXOC6A, SEC15, SEC15L, SEC15L1, SEC15L3, Sec15p
  • Links
    NCBI Gene ID: 54536
    neXtProt AC: NX_Q8TAG9
    UniProt: Q8TAG9

  • Chr Location
    10q23.33; chr10:92826831-93059494 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 1 allele in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation exhibit severe microcytic anemia, erythrocyte hyperchromia, and markedly increased levels of red cell protoporphyrin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053799 Ensembl Gene Model | MGI Sequence Detail 132828 C57BL/6J ±  kb
    transcript ENSMUST00000066439 Ensembl | MGI Sequence Detail 2729 Not Applicable  
    polypeptide ENSMUSP00000064332 Ensembl | MGI Sequence Detail 804 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      1304 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR007225 Exocyst complex component EXOC6/Sec15
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 2
      cDNA 48

      Microarray probesets 6
    Other
    Accession IDs
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    MGD-MRK-10640, MGI:2147727, MGI:96028
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 17
    • Earliest
      J:5208 Scheufler H, [An additional house mouse mutant with anemia (hemoglobin deficiency)]. Z Versuchstierkd. 1969;11(5):348-53
    • Latest
      J:195311 Chiba S, et al., NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15. EMBO J. 2013 Mar 20;32(6):874-85

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory