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Npas3 Gene Detail
Summary
  • Symbol
    Npas3
  • Name
    neuronal PAS domain protein 3
  • Synonyms
    4930423H22Rik, bHLHe12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351610
    NCBI Gene: 27386
Location & Maps
more
  • Sequence Map
    Chr12:53248677-54072175 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      823499 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 22.31 cM, cytoband C1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NPAS3, neuronal PAS domain protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NPAS3, neuronal PAS domain protein 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHe12, MOP6, PASD6
  • Links
    NCBI Gene ID: 64067
    neXtProt AC: NX_Q8IXF0

  • Chr Location
    14q13.1; chr14:32934909-33804176 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8461
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NPAS3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Npas3
  • Incidental Mutations
Mice homozygous for some knock-out alleles exhibit abnormal behavior and nervous system morphology. Mice homozygous for another knock-out allele exhibit defective lung branching morphogenesis and die shortly after birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021010 Ensembl Gene Model | MGI Sequence Detail 823499 C57BL/6J ±  kb
transcript ENSMUST00000101432 Ensembl | MGI Sequence Detail 5879 Not Applicable  
polypeptide ENSMUSP00000098975 Ensembl | MGI Sequence Detail 925 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    8413 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1918894
References
more
  • Summaries
    All 37
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:24330 Cserjesi P, et al., Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis. Development. 1995 Apr;121(4):1099-110
  • Latest
    J:217449 Stanco A, et al., NPAS1 represses the generation of specific subtypes of cortical interneurons. Neuron. 2014 Dec 3;84(5):940-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory