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Mmel1
Gene Detail
 Symbol
Name
ID
Mmel1
membrane metallo-endopeptidase-like 1
MGI:1351603
Synonyms Mell1, Nep2, NEPLP alpha, NEPLP beta, NEPLP gamma, Nl1, SEP
Feature Type protein coding gene
Genetic Map
Chromosome 4
85.54 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:154869585-154895521 bp, + strand
From VEGA annotation of GRCm38

  25937 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22778  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: neprilysin-like metallopeptidase
Gene Tree: Mmel1

Human
homologs
Human Homolog MMEL1, membrane metallo-endopeptidase-like 1
NCBI Gene ID 79258
neXtProt AC  NX_Q495T6
Human Synonyms  MMEL2, NEP2, NEPII, NL1, NL2, SEP
Human Chr (Location)  1p36; chr1:2590642-2633042 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Genomic Mutations involving Mmel1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display impaired male fertility. Female fertility is not affected.
 
Interactions
Mmel1 interacts with 55 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process proteolysis
Component endoplasmic reticulum, extracellular region, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(3) cDNA(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000010458 (Evidence)
Ensembl Gene ModelENSMUSG00000058183 (Evidence)
Entrez Gene27390 (Evidence)
DFCITC1584653, TC1625107, TC1738841
DoTSDT.101128063, DT.91337371, DT.94171217, DT.94177068
NIA Mouse Gene IndexU005191
EC3.4.24.11
Consensus CDS ProjectCCDS51401.1
International Mouse Knockout Project StatusMmel1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010458 VEGA Gene Model | MGI Sequence Detail 25937 C57BL/6J ±  kb
transcript OTTMUST00000024348 VEGA | MGI Sequence Detail 2669 Not Applicable 
polypeptide OTTMUSP00000011202 VEGA | MGI Sequence Detail 782 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(2) UniProt(8)
Polymorphisms SNPs within 2kb(280 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR000718 Peptidase M13
InterPro IPR018497 Peptidase M13, C-terminal domain
InterPro IPR008753 Peptidase M13, N-terminal domain
Protein Ontology PR:000010467 membrane metallo-endopeptidase-like 1
References (Earliest) J:58258 Ikeda K, et al., Molecular identification and characterization of novel membrane-bound metalloprotease, the soluble secreted form of which hydrolyzes a variety of vasoactive peptides. J Biol Chem. 1999 Nov 5;274(45):32469-77
(Latest) J:168082 Hafez D, et al., Neprilysin-2 is an important beta-amyloid degrading enzyme. Am J Pathol. 2011 Jan;178(1):306-12
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory