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Mmel1
Gene Detail
Symbol

Name
ID
Mmel1
membrane metallo-endopeptidase-like 1
MGI:1351603
Synonyms
Mell1, Nep2, NEPLP alpha, NEPLP beta, NEPLP gamma, Nl1, SEP
Feature Type
protein coding gene
Genetic Map
Chromosome 4
85.54 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:154869585-154895521 bp, + strand
From VEGA annotation of GRCm38

  25937 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22778  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MMEL1
Protein SuperFamily: neprilysin-like metallopeptidase
Gene Tree: Mmel1

Human
homologs
MMEL1, membrane metallo-endopeptidase-like 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 79258
neXtProt AC: NX_Q495T6

Human Synonyms: MMEL2, NEP2, NEPII, NL1, NL2, SEP

Human Chr (Location): 1p36; chr1:2590639-2633042 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Genomic Mutations involving Mmel1 (3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display impaired male fertility. Female fertility is not affected.
 
Interactions
Mmel1 interacts with 54 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process proteolysis
Component endoplasmic reticulum, extracellular region, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(3)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mmel1    NEW 
Molecular
reagents
All nucleic(3) cDNA(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000010458 (Evidence)
Ensembl Gene Model ENSMUSG00000058183 (Evidence)
Entrez Gene 27390 (Evidence)
DFCI TC1584653, TC1625107, TC1738841
DoTS DT.94177068, DT.94171217, DT.91337371, DT.101128063
NIA Mouse Gene Index U005191
EC 3.4.24.11
Consensus CDS Project CCDS51401.1
International Mouse Phenotyping Consortium Status Mmel1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010458 VEGA Gene Model | MGI Sequence Detail 25937 C57BL/6J ±  kb
transcript OTTMUST00000024348 VEGA | MGI Sequence Detail 2669 Not Applicable 
polypeptide OTTMUSP00000011202 VEGA | MGI Sequence Detail 782 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(2) UniProt(8)
Polymorphisms
SNPs within 2kb(280 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR000718 Peptidase M13
InterPro IPR018497 Peptidase M13, C-terminal domain
InterPro IPR008753 Peptidase M13, N-terminal domain
Protein Ontology PR:000010467 membrane metallo-endopeptidase-like 1
References
(Earliest) J:58258 Ikeda K, et al., Molecular identification and characterization of novel membrane-bound metalloprotease, the soluble secreted form of which hydrolyzes a variety of vasoactive peptides. J Biol Chem. 1999 Nov 5;274(45):32469-77
(Latest) J:168082 Hafez D, et al., Neprilysin-2 is an important beta-amyloid degrading enzyme. Am J Pathol. 2011 Jan;178(1):306-12
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory