Dusp13 MGI Mouse Gene Detail - MGI:1351599 - dual specificity phosphatase 13

Symbol

Dusp13
Name

dual specificity phosphatase 13
Synonyms

LMW-DSP6, LOC382853, TMDP, TS-DSP6

Feature Type

protein coding gene
IDs

MGI:1351599
NCBI Gene: 27389
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr14:21783460-21798704 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 11.85 cM, cytoband B
Mapping Data

4 experiments

SNPs within 2kb

131 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351599	protein coding gene	Chr14:21783460-21801249 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021054	protein coding gene	Chr14:14574783-14593264 (-)
A/J	MGP_AJ_G0021003	protein coding gene	Chr14:14191767-14209554 (-)
AKR/J	MGP_AKRJ_G0020980	protein coding gene	Chr14:14756591-14774436 (-)
BALB/cJ	MGP_BALBcJ_G0021006	protein coding gene	Chr14:14298755-14316518 (-)
C3H/HeJ	MGP_C3HHeJ_G0020790	protein coding gene	Chr14:14681274-14699485 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021439	protein coding gene	Chr14:15056672-15074459 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019007	protein coding gene	Chr14:14506048-14524602 (-)
CAST/EiJ	MGP_CASTEiJ_G0020314	protein coding gene	Chr14:14486646-14508117 (-)
CBA/J	MGP_CBAJ_G0020756	protein coding gene	Chr14:15825432-15848675 (-)
DBA/2J	MGP_DBA2J_G0020879	protein coding gene	Chr14:14027383-14045107 (-)
FVB/NJ	MGP_FVBNJ_G0020862	protein coding gene	Chr14:13914119-13932397 (-)
LP/J	MGP_LPJ_G0020955	protein coding gene	Chr14:14782093-14801564 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020888	protein coding gene	Chr14:15581150-15602100 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021472	protein coding gene	Chr14:14535208-14554286 (-)
PWK/PhJ	MGP_PWKPhJ_G0020063	protein coding gene	Chr14:13613843-13632513 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019885	protein coding gene	Chr14:14353537-14371554 (-)
WSB/EiJ	MGP_WSBEiJ_G0020370	protein coding gene	Chr14:14529451-14547271 (-)

Human Ortholog

DUSP13, dual specificity phosphatase 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DUSP13, dual specificity phosphatase 13
Synonyms

BEDP, DUSP13A, DUSP13B, MDSP, SKRP4, TMDP
Links

HGNC:19681

NCBI Gene ID: 51207

neXtProt AC: NX_Q6B8I1, NX_Q9UII6

UniProt: Q6B8I1, Q9UII6
Chr Location

10q22.2; chr10:75094432-75109221 (-) GRCh38.p7

Alliance of Genome Resources

Dusp13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DUSP13
Gene Tree

Dusp13

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

681
Tissues

4
cDNA Data

8
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dusp13

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Dusp13 interacts with 157 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

82
RefSeq

14
UniProt

12
CCDS

CCDS26864.1, CCDS36821.1, CCDS88592.1, CCDS88593.1

Ensembl

ENSMUSG00000021768 (Evidence)
NCBI Gene

27389

			Length	Strain/Species	Flank
genomic	27389	NCBI Gene Model \| MGI Sequence Detail	15245	C57BL/6J	± kb
transcript	NM_001007268	RefSeq \| MGI Sequence Detail	1745	Not Specified
polypeptide	Q9QYJ7	UniProt \| EBI \| MGI Sequence Detail	198	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000006740 dual specificity protein phosphatase 13

(term hierarchy)
EC

3.1.3.16, 3.1.3.48
InterPro Domains

IPR020405 Atypical dual specificity phosphatase, subfamily A

IPR000340 Dual specificity phosphatase, catalytic domain

IPR020422 Dual specificity protein phosphatase domain

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 8

cDNA 8

Microarray probesets 4

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MGI:2686049

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 7
Earliest

J:59256 Nakamura K, et al., Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis. Biochem J. 1999 Dec 15;344 Pt 3:819-25
Latest

J:274697 Celaya AM, et al., Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss. Elife. 2019 Apr 2;8:e39159

TSS for Dusp13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127688	Chr14:21798678-21798718 (-)	6 bp
Tssr127687	Chr14:21795272-21795303 (-)	3,416 bp
Tssr127686	Chr14:21792977-21792986 (-)	5,722 bp
Tssr127685	Chr14:21792972-21792976 (-)	5,730 bp
Tssr127684	Chr14:21792938-21792961 (-)	5,754 bp
Tssr127683	Chr14:21791548-21791571 (-)	7,144 bp
Tssr127682	Chr14:21791531-21791538 (-)	7,169 bp
Tssr127681	Chr14:21791517-21791524 (-)	7,183 bp
Tssr127680	Chr14:21790490-21790513 (-)	8,202 bp
Tssr127679	Chr14:21790463-21790488 (-)	8,228 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/23/2022 MGI 6.20