About   Help   FAQ
Nagpa Gene Detail
Summary
  • Symbol
    Nagpa
  • Name
    N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
  • Synonyms
    alpha-GlcNAcase, UCE
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351598
    NCBI Gene: 27426
  • Gene Overview
    MyGene.info: NAGPA
Location & Maps
more
  • Genetic Map
    Chromosome 16, 2.51 cM, cytoband A2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NAGPA, N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NAGPA, N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APAA, UCE
  • Links
    NCBI Gene ID: 51172
    neXtProt AC: NX_Q9UK23

  • Chr Location
    16p13.3; chr16:5024844-5033941 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8466
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: NAGPA
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Gene trapped
    1
  • Targeted
    2
Mice homozygous for a null allele have an increased level of acid hydrolases, however the hydrolases contain GlcNAc-P-Man diesters, exhibit a decreased affinity for the cation-independent mannose 6-phosphate receptor and fail to bind to the cation-dependent mannose 6-phosphate receptor.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028133 VEGA Gene Model | MGI Sequence Detail 8724 C57BL/6J ±  kb
transcript OTTMUST00000069688 VEGA | MGI Sequence Detail 2143 Not Applicable  
polypeptide OTTMUSP00000035432 VEGA | MGI Sequence Detail 517 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    42 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000010963 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
  • EC
  • InterPro Domains
    IPR013032 EGF-like, conserved site
    IPR018711 Phosphodiester glycosidase
Molecular
Reagents
less
  • All nucleic 40
    cDNA 39
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146461
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:58331 Kornfeld R, et al., Molecular cloning and functional expression of two splice forms of human N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. J Biol Chem. 1999 Nov 12;274(46):32778-85
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory