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Nagpa Gene Detail
Summary
  • Symbol
    Nagpa
  • Name
    N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
  • Synonyms
    alpha-GlcNAcase, UCE
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351598
    NCBI Gene: 27426
  • Gene Overview
    MyGene.info: NAGPA
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:5195289-5204012 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 2.51 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351598
protein coding gene Chr16:5195280-5204034 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022486
protein coding gene Chr16:1729952-1738691 (-)
A/J MGP_AJ_G0022448
protein coding gene Chr16:1536110-1546637 (-)
AKR/J MGP_AKRJ_G0022425
protein coding gene Chr16:1729535-1738141 (-)
BALB/cJ MGP_BALBcJ_G0022453
protein coding gene Chr16:1686888-1695800 (-)
C3H/HeJ MGP_C3HHeJ_G0022220
protein coding gene Chr16:1756482-1765113 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022902
protein coding gene Chr16:1816583-1825981 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020423
protein coding gene Chr16:1469083-1477647 (-)
CAST/EiJ MGP_CASTEiJ_G0021746
protein coding gene Chr16:1760722-1769167 (-)
CBA/J MGP_CBAJ_G0022189
protein coding gene Chr16:1912841-1927561 (-)
DBA/2J MGP_DBA2J_G0022320
protein coding gene Chr16:1630447-1639265 (-)
FVB/NJ MGP_FVBNJ_G0022295
protein coding gene Chr16:1630620-1639299 (-)
LP/J MGP_LPJ_G0022388
protein coding gene Chr16:1723380-1731874 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022317
protein coding gene Chr16:1759918-1768597 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022914
protein coding gene Chr16:1699064-1708594 (-)
PWK/PhJ MGP_PWKPhJ_G0021486
protein coding gene Chr16:1720212-1728904 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021317
protein coding gene Chr16:1796866-1805620 (-)
WSB/EiJ MGP_WSBEiJ_G0021795
protein coding gene Chr16:1732710-1741355 (-)



Homology
more
  • Human Ortholog
    NAGPA, N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NAGPA, N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APAA, UCE
  • Links
    NCBI Gene ID: 51172
    neXtProt AC: NX_Q9UK23
    UniProt: Q9UK23

  • Chr Location
    16p13.3; chr16:5024844-5033941 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8466
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NAGPA
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have an increased level of acid hydrolases, however the hydrolases contain GlcNAc-P-Man diesters, exhibit a decreased affinity for the cation-independent mannose 6-phosphate receptor and fail to bind to the cation-dependent mannose 6-phosphate receptor.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023143 Ensembl Gene Model | MGI Sequence Detail 8724 C57BL/6J ±  kb
transcript ENSMUST00000023911 Ensembl | MGI Sequence Detail 2143 Not Applicable  
polypeptide ENSMUSP00000023911 Ensembl | MGI Sequence Detail 517 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 40
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146461
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:58331 Kornfeld R, et al., Molecular cloning and functional expression of two splice forms of human N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. J Biol Chem. 1999 Nov 12;274(46):32778-85
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory