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Insl6
Gene Detail
Symbol

Name
ID
Insl6
insulin-like 6
MGI:1351595
Synonyms
relaxin/insulin-like factor 1, RIF1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
23.82 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:29321344-29325356 bp, - strand
From VEGA annotation of GRCm38

  4013 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: insulin-like peptide 6
Gene Tree: Insl6

Human
homologs
Human Homolog INSL6, insulin-like 6
NCBI Gene ID 11172
neXtProt AC  NX_Q9Y581
Human Synonyms  RIF1
Human Chr (Location)  9p24; chr9:5163863-5185618 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit male infertility associated with male germ cell apoptosis and reduced sperm motility.
 
Interactions
Insl6 interacts with 14 markers (Mir208a, Mir208b, Mir361, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process fertilization, male gonad development, ...
Component extracellular region
Function hormone activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(25) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000044338 (Evidence)
Ensembl Gene ModelENSMUSG00000050957 (Evidence)
Entrez Gene27356 (Evidence)
UniGene306511
DFCITC1582987
DoTSDT.489907
NIA Mouse Gene IndexU038956
Consensus CDS ProjectCCDS29732.1
International Mouse Knockout Project StatusInsl6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044338 VEGA Gene Model | MGI Sequence Detail 4013 C57BL/6J ±  kb
transcript OTTMUST00000116685 VEGA | MGI Sequence Detail 708 Not Applicable 
polypeptide OTTMUSP00000065051 VEGA | MGI Sequence Detail 191 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022353 Insulin, conserved site
InterPro IPR016179 Insulin-like
InterPro IPR017100 Insulin-like peptide 6
Protein Ontology PR:000009061 insulin-like peptide INSL6
References
(Earliest) J:58920 Hsu SY, Cloning of two novel mammalian paralogs of relaxin/insulin family proteins and their expression in testis and kidney. Mol Endocrinol. 1999 Dec;13(12):2163-74
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory