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Dok3
Gene Detail
 Symbol
Name
ID
Dok3
docking protein 3
MGI:1351490
Synonyms p62Dok-like protein
Feature Type protein coding gene
Genetic Map
Chromosome 13
30.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:55523235-55528538 bp, - strand
From NCBI annotation of GRCm38

  5304 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8448  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken

Gene Tree: Dok3

Human
homologs
Human Homolog DOK3, docking protein 3
NCBI Gene ID 79930
neXtProt AC  NX_Q7L591
Human Synonyms  DOKL
Human Chr (Location)  5q35.3; chr5:177501904-177510426 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased incidence of lung adenocarcinomas.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process Ras protein signal transduction
Component cytoplasm, membrane, ...
Function insulin receptor binding, protein binding
External Resources: FuncBase
Expression
cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(25)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000035711 (Evidence)
Entrez Gene27261 (Evidence)
UniGene33910
DFCITC1581149, TC1608943
DoTSDT.101251863, DT.487197
NIA Mouse Gene IndexU034818
Consensus CDS ProjectCCDS26548.1
International Mouse Knockout Project StatusDok3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 27261 NCBI Gene Model | MGI Sequence Detail 5304 C57BL/6J ±  kb
transcript NM_013739 RefSeq | MGI Sequence Detail 1546 C57BL/6 
polypeptide Q9QZK7 UniProt | EBI | MGI Sequence Detail 444 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002404 Insulin receptor substrate-1, PTB
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000006630 docking protein 3
Graphical View of Protein Domain Structure
References (Earliest) J:58605 Cong F, et al., Characterization of a novel member of the DOK family that binds and modulates Abl signaling. Mol Cell Biol. 1999 Dec;19(12):8314-25
(Latest) J:173993 Schnyder T, et al., B cell receptor-mediated antigen gathering requires ubiquitin ligase cbl and adaptors grb2 and dok-3 to recruit Dynein to the signaling microcluster. Immunity. 2011 Jun 24;34(6):905-18
All references(33)
Other
accession IDs
MGI:2145244

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory