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Dok3 Gene Detail
Summary
  • Symbol
    Dok3
  • Name
    docking protein 3
  • Synonyms
    p62Dok-like protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351490
    NCBI Gene: 27261
  • Gene Overview
    MyGene.info: DOK3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:55523231-55529296 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 30.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    35 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351490
protein coding gene Chr13:55523231-55530345 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020601
protein coding gene Chr13:55012647-55017952 (-)
A/J MGP_AJ_G0020555
protein coding gene Chr13:52978026-52983366 (-)
AKR/J MGP_AKRJ_G0020533
protein coding gene Chr13:54543815-54549381 (-)
BALB/cJ MGP_BALBcJ_G0020551
protein coding gene Chr13:53210298-53215625 (-)
C3H/HeJ MGP_C3HHeJ_G0020350
protein coding gene Chr13:54354928-54360291 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020985
protein coding gene Chr13:56669848-56675107 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018567
protein coding gene Chr13:50916183-50921723 (-)
CAST/EiJ MGP_CASTEiJ_G0019864
protein coding gene Chr13:54457814-54463153 (-)
CBA/J MGP_CBAJ_G0020310
protein coding gene Chr13:58848043-58853383 (-)
DBA/2J MGP_DBA2J_G0020433
protein coding gene Chr13:52529233-52534540 (-)
FVB/NJ MGP_FVBNJ_G0020412
protein coding gene Chr13:52000044-52005344 (-)
LP/J MGP_LPJ_G0020509
protein coding gene Chr13:55265646-55270956 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020441
protein coding gene Chr13:58312130-58317432 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021028
protein coding gene Chr13:54123746-54129021 (-)
PWK/PhJ MGP_PWKPhJ_G0019620
protein coding gene Chr13:52556274-52561670 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019447
protein coding gene Chr13:53053298-53058639 (-)
WSB/EiJ MGP_WSBEiJ_G0019926
protein coding gene Chr13:54482601-54487920 (-)



Homology
more
  • Human Ortholog
    DOK3, docking protein 3
  • Vertebrate Orthologs
    6
  • Human Ortholog
    DOK3, docking protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DOKL
  • Links
    NCBI Gene ID: 79930
    neXtProt AC: NX_Q7L591
    UniProt: Q7L591

  • Chr Location
    5q35.3; chr5:177501904-177510507 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased incidence of lung adenocarcinomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035711 Ensembl Gene Model | MGI Sequence Detail 6066 C57BL/6J ±  kb
transcript ENSMUST00000223563 Ensembl | MGI Sequence Detail 1644 Not Applicable  
polypeptide ENSMUSP00000153308 Ensembl | MGI Sequence Detail 444 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    Genomic 2
    cDNA 26

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145244
References
more
  • Summaries
    All 38
    Diseases 1
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:259912 Peters LA, et al., A functional genomics predictive network model identifies regulators of inflammatory bowel disease. Nat Genet. 2017 Oct;49(10):1437-1449

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory