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Phlda3 Gene Detail
Summary
  • Symbol
    Phlda3
  • Name
    pleckstrin homology like domain, family A, member 3
  • Synonyms
    TDAG/lpl homolog 1, Tih1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351485
    NCBI Gene: 27280
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:135766119-135769136 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 59.26 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351485
protein coding gene Chr1:135766085-135769136 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016527
protein coding gene Chr1:139548901-139551926 (+)
A/J MGP_AJ_G0016510
protein coding gene Chr1:134270521-134273546 (+)
AKR/J MGP_AKRJ_G0016475
protein coding gene Chr1:138262710-138265733 (+)
BALB/cJ MGP_BALBcJ_G0016470
protein coding gene Chr1:134590582-134593599 (+)
C3H/HeJ MGP_C3HHeJ_G0016296
protein coding gene Chr1:138364274-138367299 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016931
protein coding gene Chr1:144578363-144581380 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014642
protein coding gene Chr1:127373405-127376410 (+)
CAST/EiJ MGP_CASTEiJ_G0015876
protein coding gene Chr1:137446765-137449789 (+)
CBA/J MGP_CBAJ_G0016269
protein coding gene Chr1:149581766-149584791 (+)
DBA/2J MGP_DBA2J_G0016375
protein coding gene Chr1:133264096-133267119 (+)
FVB/NJ MGP_FVBNJ_G0016374
protein coding gene Chr1:131909289-131912314 (+)
LP/J MGP_LPJ_G0016446
protein coding gene Chr1:140782816-140785833 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016399
protein coding gene Chr1:155235990-155239015 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016967
protein coding gene Chr1:138033559-138036582 (+)
PWK/PhJ MGP_PWKPhJ_G0015662
protein coding gene Chr1:132301068-132304086 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015449
protein coding gene Chr1:137015210-137018217 (+)
WSB/EiJ MGP_WSBEiJ_G0015939
protein coding gene Chr1:138068820-138071844 (+)



Homology
more
  • Human Ortholog
    PHLDA3, pleckstrin homology like domain family A member 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PHLDA3, pleckstrin homology like domain family A member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TIH1
  • Links
    NCBI Gene ID: 23612
    neXtProt AC: NX_Q9Y5J5
    UniProt: Q9Y5J5

  • Chr Location
    1q32.1; chr1:201464284-201469171 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Mice homozygous for a knock-out allele exhibit normal embryonic and placental weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041801 Ensembl Gene Model | MGI Sequence Detail 3018 C57BL/6J ±  kb
transcript ENSMUST00000038945 Ensembl | MGI Sequence Detail 1435 Not Applicable  
polypeptide ENSMUSP00000040614 Ensembl | MGI Sequence Detail 125 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 80
    cDNA 78
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:252724 Sakata N, et al., Pleckstrin homology-like domain family A, member 3 (PHLDA3) deficiency improves islets engraftment through the suppression of hypoxic damage. PLoS One. 2017;12(11):e0187927

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/22/2019
MGI 6.14
The Jackson Laboratory