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Tnfrsf12a Gene Detail
Summary
  • Symbol
    Tnfrsf12a
  • Name
    tumor necrosis factor receptor superfamily, member 12a
  • Synonyms
    Fn14, TweakR, TWEAK-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351484
    NCBI Gene: 27279
  • Gene Overview
    MyGene.info: TNFRSF12A
Location & Maps
more
  • Sequence Map
    Chr17:23675447-23677449 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2003 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 11.99 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TNFRSF12A, TNF receptor superfamily member 12A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TNFRSF12A, TNF receptor superfamily member 12A
    Orthology source: HomoloGene
  • Synonyms
    CD266, FN14, TWEAKR
  • Links
    NCBI Gene ID: 51330
    neXtProt AC: NX_Q9NP84

  • Chr Location
    16p13.3; chr16:3020312-3022383 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit significantly reduced liver progenitor ("oval") cell proliferation in response to chemically-induced liver injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023905 Ensembl Gene Model | MGI Sequence Detail 2003 C57BL/6J ±  kb
transcript ENSMUST00000024698 Ensembl | MGI Sequence Detail 963 Not Applicable  
polypeptide ENSMUSP00000024698 Ensembl | MGI Sequence Detail 129 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    12 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001955 tumor necrosis factor receptor superfamily member 12A
  • InterPro Domains
    IPR022316 Tumour necrosis factor receptor 12
Molecular
Reagents
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  • All nucleic 13
    cDNA 12
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146391, MGI:2147148
References
more
  • Summaries
    All 53
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 19
  • Earliest
    J:58335 Meighan-Mantha RL, et al., The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration. J Biol Chem. 1999 Nov 12;274(46):33166-76
  • Latest
    J:227297 Lu WY, et al., Hepatic progenitor cells of biliary origin with liver repopulation capacity. Nat Cell Biol. 2015 Aug;17(8):971-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory